PMID- 31505969
OWN - NLM
STAT- MEDLINE
DCOM- 20220202
LR  - 20220202
IS  - 1525-6014 (Electronic)
IS  - 0148-0545 (Linking)
VI  - 45
IP  - 1
DP  - 2022 Jan
TI  - Oral administration of a potassium bromate dosage: Determination and evaluation 
      of accumulated bromate on the liver of male mice.
PG  - 127-132
LID - 10.1080/01480545.2019.1662435 [doi]
AB  - In this work, we developed a simple spectrophotometric strategy for BrO(3)(-) 
      ions determination as a major water disinfection constituents in the mice's liver 
      tissues by using pararosaniline (PRA). Mice were divided into seven main groups 
      (6 doses): lowest dose KBrO(3) (G(1) 0.01 mg L(-1), G(2) 0.025 mg L(-1) and G(3) 
      0.1 mg L(-1)), highest dose KBrO(3) (G(4) 1 mg L(-1), G(5) 10 mg.L(-1) and G(6) 
      30 mg L(-1)) and control. All these groups maintained a dose-specific feeding for 
      one month, just before the bromate assessment in mice's liver samples. The 
      results revealed that groups of exposure to lower doses of drinking water did not 
      detect the presence of BrO(3)(-) accumulated in the liver tissue during the study 
      period (1-2 months). While, the BrO(3)(-) was detected in higher dosages for 
      samples analyzed in first, second, third, fourth and fifth weeks (W(1), W(2), 
      W(3), W(4), and W(5)). These results confirmed that the higher BrO(3)(-) dosages 
      (1, 10, and 30 mg L(-1)) were fatal if introduced in drinking water and could 
      accumulate in the liver tissues both for mice and for human. Detection the 
      accuracy of the method for recovery of bromate ions in liver samples (N = 5) was 
      found to be more than 95%. Relative standard deviations (RSDs) were found to be 
      less than 2.0% confirming the reproducibility of the assay technique.
FAU - Germoush, Mousa Othman
AU  - Germoush MO
AD  - Biology Department, College of Science, Jouf University, Sakaka, Saudi Arabia.
FAU - Alsohaimi, Ibrahim Hotan
AU  - Alsohaimi IH
AUID- ORCID: 0000-0002-6312-0021
AD  - Chemistry Department, College of Science, Jouf University, Sakaka, Saudi Arabia.
FAU - Alqadami, Ayoub Abdullah
AU  - Alqadami AA
AD  - Chemistry Department, College of Science, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Alothman, Zeid Abdullah
AU  - Alothman ZA
AD  - Chemistry Department, College of Science, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Ali, Hazim Mohammed
AU  - Ali HM
AD  - Chemistry Department, College of Science, Jouf University, Sakaka, Saudi Arabia.
FAU - Algamdi, Mohammad Saad
AU  - Algamdi MS
AD  - King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
FAU - Aldawsari, Abdullah Mohammed
AU  - Aldawsari AM
AD  - Chemistry Department, College of Arts & Science, Wadi Al-dawaser, Prince Sattam 
      bin Abdulaziz University, Alkharj, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20190910
PL  - United States
TA  - Drug Chem Toxicol
JT  - Drug and chemical toxicology
JID - 7801723
RN  - 0 (Bromates)
RN  - 04MB35W6ZA (potassium bromate)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - *Bromates/toxicity
MH  - *Liver
MH  - Male
MH  - Mice
MH  - Reproducibility of Results
OTO - NOTNLM
OT  - Spectrophotometric
OT  - determination
OT  - disinfection
OT  - mice's liver tissues
OT  - pararosaniline
OT  - potassium bromate
EDAT- 2019/09/12 06:00
MHDA- 2022/02/03 06:00
CRDT- 2019/09/12 06:00
PHST- 2019/09/12 06:00 [pubmed]
PHST- 2022/02/03 06:00 [medline]
PHST- 2019/09/12 06:00 [entrez]
AID - 10.1080/01480545.2019.1662435 [doi]
PST - ppublish
SO  - Drug Chem Toxicol. 2022 Jan;45(1):127-132. doi: 10.1080/01480545.2019.1662435. 
      Epub 2019 Sep 10.