PMID- 31506454
OWN - NLM
STAT- MEDLINE
DCOM- 20201028
LR  - 20210110
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 9
IP  - 1
DP  - 2019 Sep 10
TI  - Platelet-leukocyte aggregate is associated with adverse events after surgical 
      intervention for rheumatic heart disease.
PG  - 13069
LID - 10.1038/s41598-019-49253-3 [doi]
LID - 13069
AB  - Platelet-leukocyte aggregate (PLA) is implicated in the etiology of both vascular 
      lesions and cardiovascular events. This prospective cohort study aimed to examine 
      the prognostic value of PLA for major adverse cardiac and cerebrovascular events 
      (MACCE) and perioperative adverse events (AEs) in patients with rheumatic heart 
      disease undergoing surgical intervention by Cox proportional hazard regression 
      and logistic regression. A total of 244 patients were included, of whom 7 were 
      lost to follow-up. Among the analyzed 237 subjects who completed 3-year 
      follow-up, 30 experienced MACCE and 38 experienced perioperative AEs. 
      Preoperative PLA was higher in subjects who developed MACCE (13.32%) than in 
      those who did not (8.69%, p = 0.040). In multivariate regression, elevated PLA 
      was associated with increased MACCE (hazard ratio 1.51 for each quartile, 95% CI 
      1.07-2.13; p = 0.020), and perioperative AEs (odds ratio 1.61, 95% CI 1.14-2.26; 
      p = 0.007). The optimal PLA cut-off for predicting MACCE was 6.8%. Subjects with 
      PLA > 6.8% had a higher prevalence of MACCE (17.1% vs. 5.5%, p = 0.009) and 
      perioperative AEs (19.9% vs. 8.6%, p = 0.018). Kaplan-Meier analysis showed 
      shorter MACCE-free survival in patients with PLA > 6.8% (p = 0.007, log rank). 
      Elevated preoperative PLA is associated with increased MACCE and perioperative 
      AEs in patients with rheumatic valve disease undergoing surgical intervention.
FAU - Liu, Chaonan
AU  - Liu C
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Yang, Yang
AU  - Yang Y
AD  - Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 
      China.
AD  - Department of Anesthesiology, Affiliated Hospital of Guiyang Medical College, 
      Guiyang, China.
FAU - Du, Lei
AU  - Du L
AD  - Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 
      China.
FAU - Chen, Si
AU  - Chen S
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Zhang, Jie
AU  - Zhang J
AD  - Key Laboratory of Transplant Engineering and Immunology, West China Hospital, 
      Sichuan University, Chengdu, China.
FAU - Zhang, Chongwei
AU  - Zhang C
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, China.
FAU - Zhou, Jing
AU  - Zhou J
AD  - Department of Laboratory Medicine, West China Hospital, Sichuan University, 
      Chengdu, China. zhoujinghuaxi@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190910
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Platelets/*metabolism
MH  - Disease Susceptibility
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Leukocytes/*metabolism
MH  - Male
MH  - Middle Aged
MH  - *Platelet Aggregation
MH  - Postoperative Complications/*etiology/*metabolism
MH  - Proportional Hazards Models
MH  - Rheumatic Heart Disease/*complications/*metabolism/pathology/surgery
MH  - Risk Factors
PMC - PMC6737193
COIS- The authors declare no competing interests.
EDAT- 2019/09/12 06:00
MHDA- 2020/10/29 06:00
PMCR- 2019/09/10
CRDT- 2019/09/12 06:00
PHST- 2019/03/26 00:00 [received]
PHST- 2019/08/16 00:00 [accepted]
PHST- 2019/09/12 06:00 [entrez]
PHST- 2019/09/12 06:00 [pubmed]
PHST- 2020/10/29 06:00 [medline]
PHST- 2019/09/10 00:00 [pmc-release]
AID - 10.1038/s41598-019-49253-3 [pii]
AID - 49253 [pii]
AID - 10.1038/s41598-019-49253-3 [doi]
PST - epublish
SO  - Sci Rep. 2019 Sep 10;9(1):13069. doi: 10.1038/s41598-019-49253-3.