PMID- 31507126 OWN - NLM STAT- MEDLINE DCOM- 20190917 LR - 20190917 IS - 1565-1088 (Print) VI - 21 IP - 7 DP - 2019 Jul TI - The Heart Matters: Contribution of Genetic Factors in Recurrent Pericarditis. PG - 487-490 AB - Recurrent pericarditis is a state of repetitive inflammation of the pericardium with intervals of remission. The etiology of recurrent pericarditis is still largely unknown, yet most causes are presumed to be immune mediated. Genetic factors, including human leukocyte antigen (HLA) haplotypes, can be involved in dysregulation of the immune system and as a predisposition to several autoimmune conditions, including recurrent pericarditis. Several diseases are frequently associated with such manifestations. They include systemic lupus erythematosus, familial Mediterranean fever, and tumor necrosis factor receptor-associated periodic syndrome. However, idiopathic recurrent pericarditis remains the most frequently observed clinical condition and the conundrum of this disease still needs to be solved. FAU - Perricone, Carlo AU - Perricone C AD - Lupus Clinic, Rheumatology, Department of Internal Medicine, Sapienza University of Rome, Rome, Italy. FAU - Katz, Daphna AU - Katz D AD - Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel. AD - Hebrew University-Hadassah Medical School, Jerusalem, Israel. FAU - Ciccacci, Cinzia AU - Ciccacci C AD - UniCamillus, Saint Camillus International University of Health Sciences, Rome, Italy. AD - Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Rome, Italy. FAU - Ceccarelli, Fulvia AU - Ceccarelli F AD - Lupus Clinic, Rheumatology, Department of Internal Medicine, Sapienza University of Rome, Rome, Italy. FAU - Valesini, Guido AU - Valesini G AD - Lupus Clinic, Rheumatology, Department of Internal Medicine, Sapienza University of Rome, Rome, Italy. FAU - Shoenfeld, Yehuda AU - Shoenfeld Y AD - Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel. AD - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Borgiani, Paola AU - Borgiani P AD - Department of Biomedicine and Prevention, Section of Genetics, School of Medicine, University of Rome Tor Vergata, Rome, Italy. FAU - Conti, Fabrizio AU - Conti F AD - Lupus Clinic, Rheumatology, Department of Internal Medicine, Sapienza University of Rome, Rome, Italy. LA - eng PT - Journal Article PT - Review PL - Israel TA - Isr Med Assoc J JT - The Israel Medical Association journal : IMAJ JID - 100930740 RN - 0 (HLA Antigens) SB - IM MH - Autoimmune Diseases/*genetics MH - Familial Mediterranean Fever/genetics/immunology MH - *Genetic Predisposition to Disease MH - HLA Antigens/genetics MH - Haplotypes MH - Humans MH - Lupus Erythematosus, Systemic/genetics/immunology MH - Pericarditis/genetics/immunology/*physiopathology MH - Recurrence EDAT- 2019/09/12 06:00 MHDA- 2019/09/19 06:00 CRDT- 2019/09/12 06:00 PHST- 2019/09/12 06:00 [entrez] PHST- 2019/09/12 06:00 [pubmed] PHST- 2019/09/19 06:00 [medline] PST - ppublish SO - Isr Med Assoc J. 2019 Jul;21(7):487-490.