PMID- 31508483
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 25
DP  - 2019 Dec
TI  - Outcomes of patients with anemia and renal dysfunction in hospitalized heart 
      failure with preserved ejection fraction (from the CN-HF registry).
PG  - 100415
LID - 10.1016/j.ijcha.2019.100415 [doi]
LID - 100415
AB  - BACKGROUND: Although a large number of studies on heart failure with reduced 
      ejection fraction (HFrEF) have found that anemia and renal dysfunction (RD) 
      independently predicted poor outcomes, there are still few reports on patients 
      with heart failure with preserved ejection fraction (HFpEF). METHODS: Clinical 
      data of HFpEF patients registered in the China National Heart Failure 
      Registration Study (CN-HF) were evaluated and the clinical features of patients 
      with or without anemia/RD were compared to explore the impact of anemia and RD on 
      all-cause mortality and all-cause re-hospitalization. RESULTS: 1604 patients with 
      HFpEF were enrolled, the prevalence of anemia was 51.0%. Although anemia was 
      associated with increased risk of all-cause mortality and all-cause 
      re-hospitalization in univariate COX regression (p < 0.05), multivariate COX 
      model confirmed that anemia was not independently associated with all-cause 
      mortality [hazard ratio (HR) 1.14, 95% confidence interval (CI) 0.85-1.52, 
      p = 0.386] and all-cause re-hospitalization (HR 1.13, 95% CI 0.96-1.33, 
      p = 0.152). Similarly, RD was not an independent predictor of all-cause mortality 
      (HR 1.18, 95% CI 0.88-1.57, p = 0.269) and all-cause re-hospitalization (HR 0.94, 
      95% CI 0.79-1.12, p = 0.488) as assessed in the adjusted COX regression model. 
      The interaction between RD and anemia on end-points events was also not 
      statistically significant. However, anemia was associated with increased 
      all-cause re-hospitalization in patients with New York Heart Association (NYHA) 
      class III-IV. CONCLUSIONS: In patients with HFpEF from CN-HF registry, anemia was 
      common, but was not an independent predictor of all-cause mortality and all-cause 
      re-hospitalization, except for the all-cause re-hospitalization in patients with 
      NYHA class III-IV.Clinical Trial Registration: 
      http://www.clinicaltrials.gov/ct2/home; ID: NCT02079428.
FAU - Jin, Xuejuan
AU  - Jin X
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Cao, Juan
AU  - Cao J
AD  - North Sichuan Medical College, Department of Cardiology, The Affiliated Hospital 
      of North Sichuan Medical College, Nanchong, Sichuan, China.
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Zhou, Jun
AU  - Zhou J
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Wang, Yanyan
AU  - Wang Y
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Han, Xueting
AU  - Han X
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Song, Yu
AU  - Song Y
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Fan, Yuyuan
AU  - Fan Y
AD  - North Sichuan Medical College, Department of Cardiology, The Affiliated Hospital 
      of North Sichuan Medical College, Nanchong, Sichuan, China.
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Chen, Zhenyue
AU  - Chen Z
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiaotong University School of 
      Medicine, Shanghai, China.
FAU - Xu, Dingli
AU  - Xu D
AD  - Department of Cardiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Yang, Xinchun
AU  - Yang X
AD  - Heart Center, Beijing Chaoyang Hospital affiliated to Capital Medical University, 
      Beijing, China.
FAU - Dong, Wei
AU  - Dong W
AD  - Department of Cardiology, Chinese People's Liberation Army General Hospital, 
      Beijing, China.
FAU - Li, Liwen
AU  - Li L
AD  - Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General 
      Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
FAU - Chen, Li
AU  - Chen L
AD  - North Sichuan Medical College, Department of Cardiology, The Affiliated Hospital 
      of North Sichuan Medical College, Nanchong, Sichuan, China.
FAU - Zhong, Qiaoqing
AU  - Zhong Q
AD  - Department of Cardiology, First People's Hospital of Chenzhou, Chenzhou, China.
FAU - Fu, Micheal
AU  - Fu M
AD  - Section of Cardiology, Department of Medicine, Sahlgrenska University 
      Hospital/Ostra Hospital, University of Gothenburg, Gothenburg, Sweden.
FAU - Hu, Kai
AU  - Hu K
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Zhou, Jingmin
AU  - Zhou J
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
FAU - Ge, Junbo
AU  - Ge J
AD  - Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 
      Institute of Cardiovascular Diseases, Shanghai, China.
CN  - CN-HF investigators
LA  - eng
SI  - ClinicalTrials.gov/NCT02079428
PT  - Journal Article
DEP - 20190831
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC6726881
OTO - NOTNLM
OT  - ACEI, angiotensin converting enzyme inhibitors
OT  - AF, atrial fibrillation
OT  - ARB, angiotensin receptor blockers
OT  - Anemia
OT  - BNP, brain natriuretic peptide
OT  - CI, confidence interval
OT  - CN-HF, China National Heart Failure Registration Study
OT  - CRFs, case report forms
OT  - HDL, high density lipoprotein cholesterol
OT  - HF, Heart failure
OT  - HFpEF, heart failure with preserved ejection fraction
OT  - HFrEF, heart failure with reduced ejection fraction
OT  - HR, hazard ratio
OT  - Heart failure
OT  - Heart failure with preserved ejection fraction
OT  - LDL, low density lipoprotein cholesterol
OT  - LVDD, left ventricular diastolic dimension
OT  - LVEF, left ventricular ejection fraction
OT  - MRA, mineralocorticoid receptor antagonist
OT  - NT-proBNP, N-terminal pro-brain natriuretic peptide
OT  - NYHA, New York Heart Association
OT  - RD, renal dysfunction
OT  - Renal dysfunction
OT  - TC, serum total cholesterol
OT  - TG, triglyceride
OT  - eGFR, estimated glomerular filtration rate
EDAT- 2019/09/12 06:00
MHDA- 2019/09/12 06:01
PMCR- 2019/08/31
CRDT- 2019/09/12 06:00
PHST- 2019/06/14 00:00 [received]
PHST- 2019/08/03 00:00 [revised]
PHST- 2019/08/18 00:00 [accepted]
PHST- 2019/09/12 06:00 [entrez]
PHST- 2019/09/12 06:00 [pubmed]
PHST- 2019/09/12 06:01 [medline]
PHST- 2019/08/31 00:00 [pmc-release]
AID - S2352-9067(19)30123-X [pii]
AID - 100415 [pii]
AID - 10.1016/j.ijcha.2019.100415 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2019 Aug 31;25:100415. doi: 
      10.1016/j.ijcha.2019.100415. eCollection 2019 Dec.