PMID- 31508793
OWN - NLM
STAT- MEDLINE
DCOM- 20190930
LR  - 20221114
IS  - 1678-7765 (Electronic)
IS  - 1678-7757 (Print)
IS  - 1678-7757 (Linking)
VI  - 27
DP  - 2019 Sep 9
TI  - Updating the role of matrix metalloproteinases in mineralized tissue and related 
      diseases.
PG  - e20180596
LID - S1678-77572019000100301 [pii]
LID - 10.1590/1678-7757-2018-0596 [doi]
LID - e20180596
AB  - Bone development and healing processes involve a complex cascade of biological 
      events requiring well-orchestrated synergism with bone cells, growth factors, and 
      other trophic signaling molecules and cellular structures. Beyond health 
      processes, MMPs play several key roles in the installation of heart and blood 
      vessel related diseases and cancer, ranging from accelerating metastatic cells to 
      ectopic vascular mineralization by smooth muscle cells in complementary manner. 
      The tissue inhibitors of MMPs (TIMPs) have an important role in controlling 
      proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, 
      they modulate MMP performance. If druggable, these molecules are suggested to be 
      a platform for development of "smart" medications and further clinical trials. 
      Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this 
      review is to update the role of those multifaceted proteases in mineralized 
      tissues in health, such as bone, and pathophysiological disorders, such as 
      ectopic vascular calcification and cancer.
FAU - Tokuhara, Cintia Kazuko
AU  - Tokuhara CK
AUID- ORCID: 0000-0002-1852-5986
AD  - Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de 
      Ciencias Biologicas, Laboratorio de Bioquimica, Bauru, Sao Paulo, Brasil.
FAU - Santesso, Mariana Rodrigues
AU  - Santesso MR
AUID- ORCID: 0000-0001-9740-1780
AD  - Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de 
      Ciencias Biologicas, Laboratorio de Bioquimica, Bauru, Sao Paulo, Brasil.
FAU - Oliveira, Gabriela Silva Neubern de
AU  - Oliveira GSN
AUID- ORCID: 0000-0003-0037-5665
AD  - Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de 
      Ciencias Biologicas, Laboratorio de Bioquimica, Bauru, Sao Paulo, Brasil.
FAU - Ventura, Talita Mendes da Silva
AU  - Ventura TMDS
AUID- ORCID: 0000-0003-2101-1350
AD  - Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de 
      Ciencias Biologicas, Laboratorio de Bioquimica, Bauru, Sao Paulo, Brasil.
FAU - Doyama, Julio Toshimi
AU  - Doyama JT
AUID- ORCID: 0000-0001-9456-4111
AD  - Universidade Estadual Paulista Julio de Mesquita Filho, Campus Botucatu, Rubiao 
      Jr, Sao Paulo, Brasil.
FAU - Zambuzzi, Willian Fernando
AU  - Zambuzzi WF
AUID- ORCID: 0000-0002-4149-5965
AD  - Universidade Estadual Paulista Julio de Mesquita Filho, Campus Botucatu, Rubiao 
      Jr, Sao Paulo, Brasil.
FAU - Oliveira, Rodrigo Cardoso de
AU  - Oliveira RC
AUID- ORCID: 0000-0003-3070-5960
AD  - Universidade de Sao Paulo, Faculdade de Odontologia de Bauru, Departamento de 
      Ciencias Biologicas, Laboratorio de Bioquimica, Bauru, Sao Paulo, Brasil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190909
PL  - Brazil
TA  - J Appl Oral Sci
JT  - Journal of applied oral science : revista FOB
JID - 101189774
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (Tissue Inhibitor of Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - Bone Diseases/metabolism/physiopathology
MH  - Bone Remodeling/*physiology
MH  - Disease Progression
MH  - Extracellular Matrix/*physiology
MH  - Humans
MH  - Matrix Metalloproteinase Inhibitors/therapeutic use
MH  - Matrix Metalloproteinases/*physiology
MH  - Neoplasms/metabolism/physiopathology
MH  - Osteoblasts/physiology
MH  - Tissue Inhibitor of Metalloproteinases/physiology
MH  - Vascular Calcification/metabolism/physiopathology
PMC - PMC9648957
COIS- Conflicts of interest The authors declare that they have no conflict of interest.
EDAT- 2019/09/12 06:00
MHDA- 2019/10/01 06:00
PMCR- 2019/08/30
CRDT- 2019/09/12 06:00
PHST- 2018/10/18 00:00 [received]
PHST- 2019/05/30 00:00 [accepted]
PHST- 2019/09/12 06:00 [entrez]
PHST- 2019/09/12 06:00 [pubmed]
PHST- 2019/10/01 06:00 [medline]
PHST- 2019/08/30 00:00 [pmc-release]
AID - S1678-77572019000100301 [pii]
AID - 10.1590/1678-7757-2018-0596 [doi]
PST - epublish
SO  - J Appl Oral Sci. 2019 Sep 9;27:e20180596. doi: 10.1590/1678-7757-2018-0596.