PMID- 31508877
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
DP  - 2019 Sep 11
TI  - The association between thyroid dysfunction (TD) and diabetic kidney disease 
      (DKD) in type 2 diabetes mellitus (T2DM).
PG  - e13415
LID - 10.1111/ijcp.13415 [doi]
AB  - BACKGROUND: Epidemiological studies have identified an association between 
      thyroid dysfunction (TD) and various kidney diseases. In this study, the 
      prevalence of TD in type 2 diabetic mellitus (T2DM) patients with diabetic kidney 
      disease (DKD) was evaluated to analyse the potential association between TD and 
      DKD in T2DM patients. METHODOLOGY: A total of 2108 T2DM patients from Anhui 
      Provincial Hospital were recruited in this study. Demographic and clinical 
      characteristics were collected from 834 T2DM patients with DKD and 1274 T2DM 
      patients without DKD (non-DKD). All patients were stratified into a number of 
      groups based on UACR (urine albumin-to-creatinine ratio) or eGFR (estimated 
      glomerular filtration rate): (a) A1: normoalbuminuria (<30), A2: microalbuminuria 
      (30-300) and A3: macroalbuminuria (>300); (b) F1: normal filtration (60-139), F2: 
      hyper filtration (>/=140) and F3: low filtration (<60). RESULTS: Significant 
      differences were observed between the non-DKD and DKD groups (P < .05) in age, 
      sex ratio, duration, systolic blood pressure, total cholesterol, low density 
      lipoprotein cholesterol, serum creatinine, blood urea nitrogen, free 
      triiodothyronine (FT3), free thyroxine (FT4) and sensitive thyrotropin hormone 
      (sTSH). The macroalbuminuira and low filtration groups had the lowest levels of 
      FT3 and FT4 and the highest level of sTSH, compared with all other groups 
      (P < .0167). The prevalence of subclinical hypothyroidism in the DKD group was 
      significantly higher than that in the non-DKD group (chi(2)  = 13.92, P < .01). 
      Logistic regression analysis showed that hypothyroidism was associated with 
      increased UACR or reduced eGFR in T2DM patients. Compared with controls, T2DM 
      patients with hypothyroidism exhibited a higher UACR and urinary excretion of 
      transferrin, as well as a lower excretion of urinary Tamm-Horsfall protein (THP) 
      (P < .0167). CONCLUSION: Subclinical hypothyroidism is more prevalent in T2DM 
      patients with DKD than in T2DM patients without DKD. Hypothyroidism is associated 
      with albuminuria and decreased eGFR in T2DM patients.
CI  - (c) 2019 John Wiley & Sons Ltd.
FAU - Zheng, Mao
AU  - Zheng M
AUID- ORCID: 0000-0003-2580-8949
AD  - Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, 
      University of Science and Technology of China, Hefei, P. R. China.
FAU - Wang, Dong
AU  - Wang D
AD  - Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, 
      University of Science and Technology of China, Hefei, P. R. China.
FAU - Chen, Li
AU  - Chen L
AUID- ORCID: 0000-0002-3237-6892
AD  - Department of Endocrinology, The Third Affiliated Hospital of AHMU (The First 
      People's Hospital of Hefei City), Hefei, P. R. China.
FAU - Chen, Mei-Nan
AU  - Chen MN
AD  - Ethics Committee on Clinical Research, The First Affiliated Hospital of USTC, 
      Hefei, P. R. China.
FAU - Wang, Wei
AU  - Wang W
AD  - Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, 
      University of Science and Technology of China, Hefei, P. R. China.
FAU - Ye, Shan-Dong
AU  - Ye SD
AD  - Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, 
      University of Science and Technology of China, Hefei, P. R. China.
LA  - eng
GR  - 1508085SMH227/Natural Science Research Project of Anhui Province/
GR  - 11040606M159/National Natural Science Foundation of Anhui Province/
PT  - Journal Article
DEP - 20190911
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
SB  - IM
EDAT- 2019/09/12 06:00
MHDA- 2019/09/12 06:00
CRDT- 2019/09/12 06:00
PHST- 2019/04/18 00:00 [received]
PHST- 2019/08/23 00:00 [revised]
PHST- 2019/08/31 00:00 [accepted]
PHST- 2019/09/12 06:00 [pubmed]
PHST- 2019/09/12 06:00 [medline]
PHST- 2019/09/12 06:00 [entrez]
AID - 10.1111/ijcp.13415 [doi]
PST - aheadofprint
SO  - Int J Clin Pract. 2019 Sep 11:e13415. doi: 10.1111/ijcp.13415.