PMID- 31509021
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 79
IP  - 7
DP  - 2019 Nov
TI  - Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 
      diabetes mellitus.
PG  - 519-523
LID - 10.1080/00365513.2019.1664760 [doi]
AB  - Long noncoding RNAs (lncRNAs) have emerged as key players in several biological 
      processes and complex diseases including type 2 diabetes mellitus (T2DM). The 
      purpose of this study was to investigate the expression levels of SNHG17 and 
      TTC28-AS1 in T2DM patients. Quantitative real-time RT-PCR analysis was performed 
      using peripheral blood mononuclear cells (PBMCs) samples from patients diagnosed 
      with T2DM and healthy controls. Binary logistic regression analysis was carried 
      out to determine the odds of development of T2DM based on expression levels of 
      lncRNAs and clinical characteristic of the subjects. Spearman's correlation 
      analysis was used to clarify the correlation between SNHG17 and TTC28-AS1 
      expressions to metabolic features. We found that SNHG17 and TTC28-AS1were 
      down-regulated in the T2DM group compared to the healthy control group. The 
      logistic regression revealed that body mass index (BMI), systolic blood pressure 
      (SBP), fasting blood glucose (FBG) and TTC28-AS1 expression substantially affect 
      T2DM susceptibility. Furthermore, expression of SNHG17 was negatively correlated 
      with high-density lipoprotein cholesterol (HDL-C) and expression of TTC28-AS1 was 
      positively correlated with low-density lipoprotein cholesterol (LDL-C). Decreased 
      expressions of lncRNAs TTC28-AS1 and SNHG17 in T2DM are possibly associated with 
      the development of T2DM.
FAU - Mohamadi, Mahroo
AU  - Mohamadi M
AD  - Department of Medical Laboratory Sciences, School of Allied Medical Sciences, 
      Shahid Beheshti University of Medical Sciences , Tehran , Iran.
FAU - Ghaedi, Hamid
AU  - Ghaedi H
AD  - Department of Medical Genetics, Faculty of Medicine, Shahid Beheshti University 
      of Medical Sciences , Tehran , Iran.
FAU - Kazerouni, Faranak
AU  - Kazerouni F
AD  - Department of Medical Laboratory Sciences, School of Allied Medical Sciences, 
      Shahid Beheshti University of Medical Sciences , Tehran , Iran.
FAU - Erfanian Omidvar, Maryam
AU  - Erfanian Omidvar M
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti 
      University of Medical Sciences , Tehran , Iran.
FAU - Kalbasi, Saeid
AU  - Kalbasi S
AD  - Department of Endocrinology, Loghman Hospital, Shahid Beheshti University of 
      Medical Sciences , Tehran , Iran.
FAU - Shanaki, Mehrnoosh
AU  - Shanaki M
AD  - Department of Medical Laboratory Sciences, School of Allied Medical Sciences, 
      Shahid Beheshti University of Medical Sciences , Tehran , Iran.
FAU - Miraalamy, Ghasem
AU  - Miraalamy G
AD  - Ali-Asghar Hospital, Iran University of Medical Sciences , Tehran , Iran.
FAU - Rahimipour, Ali
AU  - Rahimipour A
AD  - Department of Medical Laboratory Sciences, School of Allied Medical Sciences, 
      Shahid Beheshti University of Medical Sciences , Tehran , Iran.
AD  - Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti 
      University of Medical Sciences , Tehran , Iran.
LA  - eng
PT  - Journal Article
DEP - 20190911
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cholesterol, HDL/blood/genetics
MH  - Cholesterol, LDL/blood/genetics
MH  - Diabetes Mellitus, Type 2/blood/*genetics
MH  - Gene Expression Regulation
MH  - Humans
MH  - Leukocytes, Mononuclear/physiology
MH  - Logistic Models
MH  - RNA, Long Noncoding/*blood
OTO - NOTNLM
OT  - SNHG17
OT  - TTC28-AS1
OT  - gene expression
OT  - genome-wide association studies (GWASs)
OT  - long noncoding RNA
OT  - type 2 diabetes mellitus
EDAT- 2019/09/12 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/09/12 06:00
PHST- 2019/09/12 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/09/12 06:00 [entrez]
AID - 10.1080/00365513.2019.1664760 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2019 Nov;79(7):519-523. doi: 
      10.1080/00365513.2019.1664760. Epub 2019 Sep 11.