PMID- 31509848
OWN - NLM
STAT- MEDLINE
DCOM- 20200407
LR  - 20200408
IS  - 1421-9751 (Electronic)
IS  - 0008-6312 (Linking)
VI  - 144
IP  - 1-2
DP  - 2019
TI  - Prevalence of Concomitant Coronary Artery Disease and Its Impact on Acute Kidney 
      Injury for Chinese Adult Patients Undergoing Valvular Heart Surgery.
PG  - 60-68
LID - 10.1159/000502225 [doi]
AB  - INTRODUCTION: Significant coronary artery disease (CAD) in patients undergoing 
      valvular heart surgery (VHS) is an indication for combined valvular heart surgery 
      and coronary artery bypass grafting. However, the impact of nonsignificant CAD on 
      postoperative outcomes is not well understood. This study illustrated the 
      epidemiological characteristics of CAD in China and investigated the impact of 
      CAD on postoperative acute kidney injury (AKI), intensive care unit (ICU) stay, 
      and postoperative mortality. METHODS: This study comprised an epidemiological 
      survey followed by a case-control investigation. The epidemiological 
      characteristics of CAD were studied in 4,172 consecutive patients who underwent 
      coronary angiography before planned VHS at a core cardiovascular center. Then, 
      3,618 patients were selected for the subsequent case-control study to further 
      analyze the associations between CAD and postoperative advanced AKI (grade 2 or 3 
      by KDIGO criteria), longer ICU stay (highest quartile), and increased mortality 
      by logistic regression. RESULTS: Of the participants, 5.1 and 9.3% had moderate 
      and significant CAD, respectively. The incidence of CAD increased after 60 years 
      of age. Although CAD was not related to longer postoperative ICU stay in a 
      multivariate logistic model, moderate CAD (OR 1.539 [95% CI 1.078-2.199]) and 
      significant CAD (OR 1.798 [95% CI 1.094-2.955]) remained independent risk factors 
      for postoperative advanced AKI after adjusting for multiple traditional risk 
      factors. Significant CAD, but not nonsignificant CAD, was associated with 
      postoperative mortality. CONCLUSIONS: Concomitant CAD is common in Chinese 
      patients who undergo VHS. Moderate and significant CAD might have detrimental 
      effects on postoperative advanced AKI.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Xie, Zhiyong
AU  - Xie Z
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Mo, Zhiming
AU  - Mo Z
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Chen, Jimei
AU  - Chen J
AD  - Department of Cardiac Surgery, Guangdong Cardiovascular Institute, Guangdong 
      Provincial Key Laboratory of South China Structural Heart Disease, Guangdong 
      Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 
      China.
FAU - Wu, Yanhua
AU  - Wu Y
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
FAU - Chen, Shixin
AU  - Chen S
AD  - Division of Preventive Medicine, School of Public Health, Guangzhou Medical 
      University, Guangzhou, China.
FAU - Li, Zhilian
AU  - Li Z
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
FAU - Ye, Zhiming
AU  - Ye Z
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
FAU - Liang, Huaban
AU  - Liang H
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
FAU - Liu, Shuangxin
AU  - Liu S
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
FAU - Fu, Lei
AU  - Fu L
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
FAU - Chen, Yuanhan
AU  - Chen Y
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China.
FAU - Liang, Xinling
AU  - Liang X
AD  - Division of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy 
      of Medical Sciences, Guangzhou, China, xinlingliang_ggh@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190911
PL  - Switzerland
TA  - Cardiology
JT  - Cardiology
JID - 1266406
SB  - IM
MH  - Acute Kidney Injury/*epidemiology
MH  - Aged
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Coronary Angiography
MH  - *Coronary Artery Bypass
MH  - Coronary Artery Disease/*epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Intensive Care Units
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Postoperative Complications/*epidemiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Coronary angiography
OT  - Coronary artery disease
OT  - Epidemiological study
OT  - Outcome
OT  - Valvular heart surgery
EDAT- 2019/09/12 06:00
MHDA- 2020/04/09 06:00
CRDT- 2019/09/12 06:00
PHST- 2019/04/28 00:00 [received]
PHST- 2019/07/19 00:00 [accepted]
PHST- 2019/09/12 06:00 [pubmed]
PHST- 2020/04/09 06:00 [medline]
PHST- 2019/09/12 06:00 [entrez]
AID - 000502225 [pii]
AID - 10.1159/000502225 [doi]
PST - ppublish
SO  - Cardiology. 2019;144(1-2):60-68. doi: 10.1159/000502225. Epub 2019 Sep 11.