PMID- 31510754
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 35
IP  - 11-12
DP  - 2019 Nov/Dec
TI  - The Role of Natural Killer Cells and Regulatory T Cells While Aging with Human 
      Immunodeficiency Virus.
PG  - 1123-1135
LID - 10.1089/AID.2019.0134 [doi]
AB  - Combined antiretroviral therapy (cART) has increased the quality of life of 
      people living with HIV (PLHIV). Consequently, the number of PLHIV >50 years is 
      increasing worldwide. Patients on cART are known to remain in a proinflammatory 
      state. The latter is linked to the development of non-AIDS-related chronic 
      conditions. Although the number of aging PLHIV is increasing, the effect of HIV 
      infection on the process of aging is not fully understood. Understanding the 
      complexity of aging with HIV by investigating the effect of the latter on 
      different components of the innate and adaptive immune systems is important to 
      reduce the impact of these comorbid conditions and improve the quality of life of 
      PLHIV. The role of killer immunoglobulin receptors (KIRs), expressed on the 
      surface of natural killer (NK) cells, and their human leukocyte antigen (HLA) 
      ligands in the clearance, susceptibility to or disease progression following HIV 
      infection is well established. However, data on the effect of KIR-HLA interaction 
      in aging HIV-infected population and the development of non-AIDS-related comorbid 
      conditions are lacking. Moreover, conflicting data exist on the role of 
      regulatory T cells (Tregs) during HIV infection. The purpose of this review is to 
      advance the current knowledge on the role of NK cells and Tregs while aging with 
      HIV infection.
FAU - Abou Hassan, Farouk
AU  - Abou Hassan F
AD  - Medical Laboratory Sciences Program, Division of Health Professions, Faculty of 
      Health Sciences, American University of Beirut, Beirut, Lebanon.
FAU - Bou Hamdan, Mirna
AU  - Bou Hamdan M
AD  - Medical Laboratory Sciences Program, Division of Health Professions, Faculty of 
      Health Sciences, American University of Beirut, Beirut, Lebanon.
FAU - Melhem, Nada M
AU  - Melhem NM
AD  - Medical Laboratory Sciences Program, Division of Health Professions, Faculty of 
      Health Sciences, American University of Beirut, Beirut, Lebanon.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191024
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
RN  - 0 (Anti-HIV Agents)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Aging/*immunology
MH  - Anti-HIV Agents/therapeutic use
MH  - Disease Progression
MH  - HIV Infections/drug therapy/*immunology
MH  - HIV-1
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Killer Cells, Natural/*immunology
MH  - Quality of Life
MH  - T-Lymphocytes, Regulatory/*immunology
OTO - NOTNLM
OT  - HIV
OT  - KIRs
OT  - NK cells
OT  - Tregs
OT  - aging
EDAT- 2019/09/13 06:00
MHDA- 2020/09/10 06:00
CRDT- 2019/09/13 06:00
PHST- 2019/09/13 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2019/09/13 06:00 [entrez]
AID - 10.1089/AID.2019.0134 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2019 Nov/Dec;35(11-12):1123-1135. doi: 
      10.1089/AID.2019.0134. Epub 2019 Oct 24.