PMID- 31512197 OWN - NLM STAT- MEDLINE DCOM- 20220211 LR - 20240130 IS - 1532-6551 (Electronic) IS - 1071-3581 (Linking) VI - 28 IP - 4 DP - 2021 Aug TI - (18)F-sodium fluoride PET/MRI myocardial imaging in patients with suspected cardiac amyloidosis. PG - 1586-1595 LID - 10.1007/s12350-019-01885-8 [doi] AB - BACKGROUND: We evaluated the diagnostic performance of (18)F-NaF PET/MRI in patients with suspected cardiac amyloidosis (CA). METHODS: Twenty-seven consecutive patients underwent myocardial PET 1 hour after injection of 4 MBq/kg (18)F-NaF with simultaneous MRI including cine-MRI, T1 and T2 mapping, first-pass and late gadolinium enhancement (LGE). (18)F-NaF uptake was measured visually and semi-quantitatively by calculating myocardium-to-blood pool (M/B) ratios. CA was confirmed histologically. RESULTS: Transthyretin (TTR)-CA was diagnosed in 16 patients, light-chain (AL)-CA in 7, and no-CA in 4. Visual interpretation of (18)F-NaF images revealed a relative increase in myocardial uptake in only 3 patients, all with TTR CA, and a relative decrease in 13, including 7 AL CA, 3 no-CA, and 3 TTR CA. M/B ratios were significantly higher in TTR CA (1.00 +/- 0.12) than in AL CA (0.81 +/- 0.06, P = 0.001) or in no-CA (0.73 +/- 0.16, P = 0.006). The optimal M/B cut-off to distinguish TTR CA from AL CA was >/= 0.90 (Fischer, P = 0.0005). By comparison, classification of patients using (99m)Tc-HMDP heart-to-mediastinum ratios with the previously published cut-off >/= 1.21 reached higher significance (P < 0.0001). Among MRI parameters, myocardial T1, LGE score, and extracellular volume were higher in CA than in no-CA patients, 1409 +/- 76 vs 1278 +/- 35 ms (P = 0.004), 10.35 +/- 5.30 vs 3.50 +/- 3.42 (P = 0.03), and 46 +/- 10 vs 33 +/- 8 % (P = 0.01), respectively. CONCLUSION: (18)F-NaF PET/MRI shows good diagnostic performance when semi-quantification is used. However, contrast is low and visual interpretation may be challenging in routine. PET/MRI could constitute a one-stop-shop evaluation of amyloid load and cardiac function in patients needing rapid work-up. CI - (c) 2019. American Society of Nuclear Cardiology. FAU - Abulizi, Mukedaisi AU - Abulizi M AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. AD - Amyloid Research Institute, IMRB U955, U-PEC, 94010, Creteil, France. FAU - Sifaoui, Islem AU - Sifaoui I AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. AD - Amyloid Research Institute, IMRB U955, U-PEC, 94010, Creteil, France. FAU - Wuliya-Gariepy, Mijiti AU - Wuliya-Gariepy M AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. AD - Department of Cardiology, CHU Henri Mondor, AP-HP/U-PEC, 94010, Creteil, France. FAU - Kharoubi, Mounira AU - Kharoubi M AD - Amyloid Research Institute, IMRB U955, U-PEC, 94010, Creteil, France. AD - Department of Cardiology, CHU Henri Mondor, AP-HP/U-PEC, 94010, Creteil, France. FAU - Israel, Jean-Marc AU - Israel JM AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. FAU - Emsen, Berivan AU - Emsen B AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. FAU - Bodez, Diane AU - Bodez D AD - Amyloid Research Institute, IMRB U955, U-PEC, 94010, Creteil, France. AD - Department of Cardiology, CHU Henri Mondor, AP-HP/U-PEC, 94010, Creteil, France. FAU - Monnet, Aurelien AU - Monnet A AD - Siemens Healthineers, Erlangen, Germany. FAU - Didierlaurent, David AU - Didierlaurent D AD - Siemens Healthineers, Erlangen, Germany. FAU - Tacher, Vania AU - Tacher V AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. AD - Amyloid Research Institute, IMRB U955, U-PEC, 94010, Creteil, France. FAU - Luciani, Alain AU - Luciani A AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. FAU - Damy, Thibaud AU - Damy T AD - Amyloid Research Institute, IMRB U955, U-PEC, 94010, Creteil, France. AD - Department of Cardiology, CHU Henri Mondor, AP-HP/U-PEC, 94010, Creteil, France. FAU - Deux, Jean-Francois AU - Deux JF AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. AD - Amyloid Research Institute, IMRB U955, U-PEC, 94010, Creteil, France. FAU - Itti, Emmanuel AU - Itti E AD - SyMPTOm PET/MRI platform, Departments of Nuclear Medicine and Radiology, CHU Henri Mondor Hospital, AP-HP/U-PEC, 51 Ave. du Mal de Lattre de Tassigny, 94010, Creteil, France. emmanuel.itti@aphp.fr. AD - Amyloid Research Institute, IMRB U955, U-PEC, 94010, Creteil, France. emmanuel.itti@aphp.fr. LA - eng PT - Journal Article DEP - 20190911 PL - United States TA - J Nucl Cardiol JT - Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology JID - 9423534 RN - 0 (Fluorine Radioisotopes) RN - 8ZYQ1474W7 (Sodium Fluoride) RN - GZ5I74KB8G (Fluorine-18) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Amyloidosis/*diagnostic imaging MH - Cardiomyopathies/*diagnostic imaging MH - Cohort Studies MH - Female MH - Fluorine Radioisotopes MH - Humans MH - *Magnetic Resonance Imaging MH - Male MH - Middle Aged MH - *Myocardial Perfusion Imaging MH - *Positron-Emission Tomography MH - Sensitivity and Specificity MH - Sodium Fluoride OTO - NOTNLM OT - 18F-sodium fluoride OT - Cardiac amyloidosis OT - PET/MRI OT - myocardial uptake EDAT- 2019/09/13 06:00 MHDA- 2022/02/12 06:00 CRDT- 2019/09/13 06:00 PHST- 2019/06/17 00:00 [received] PHST- 2019/07/31 00:00 [accepted] PHST- 2019/09/13 06:00 [pubmed] PHST- 2022/02/12 06:00 [medline] PHST- 2019/09/13 06:00 [entrez] AID - S1071-3581(23)00971-6 [pii] AID - 10.1007/s12350-019-01885-8 [doi] PST - ppublish SO - J Nucl Cardiol. 2021 Aug;28(4):1586-1595. doi: 10.1007/s12350-019-01885-8. Epub 2019 Sep 11.