PMID- 31513761
OWN - NLM
STAT- MEDLINE
DCOM- 20210111
LR  - 20220910
IS  - 1678-4782 (Electronic)
IS  - 0021-7557 (Print)
IS  - 0021-7557 (Linking)
VI  - 96 Suppl 1
IP  - Suppl 1
DP  - 2020 Mar-Apr
TI  - Viral encephalitis: a practical review on diagnostic approach and treatment.
PG  - 12-19
LID - S0021-7557(19)30429-2 [pii]
LID - 10.1016/j.jped.2019.07.006 [doi]
AB  - OBJECTIVES: To review the diagnostic criteria for encephalitis and encephalopathy 
      of presumed infectious etiology, as well as the diagnostic workup for viral 
      encephalitis and its treatment approaches. The authors also intended to summarize 
      relevant information on specific viruses frequently found in Brazil. SOURCE OF 
      DATA: Literature search on Pubmed/MEDLINE using the following keywords: "viral", 
      "encephalitis", "child", or "adolescents", filtering for articles on humans and 
      in English. SUMMARY OF DATA: Viral encephalitis is the most common cause of 
      encephalitis and is responsible for high rates of morbidity, permanent neurologic 
      sequelae, and according to the virus, may have high mortality rates. The most 
      common etiologies are herpesviruses 1 and 2 (HSV-1 and HSV-2), non-polio 
      enterovirus, and arboviruses (in Brazil, dengue, Zika, and chikungunya). Other 
      relevant etiologies are seasonal influenza, cytomegalovirus (CMV), Epstein-Barr 
      virus (EBV), human herpesvirus 6 (HHV-6), and the re-emergent measles. 
      CONCLUSION: Clinical data, laboratory results, and neuroimaging findings support 
      the diagnosis of encephalitis and the specific viral etiology. To increase the 
      likelihood of etiologic confirmation, it is important to know the best approach 
      to collecting samples and to choose the best identification technique for each 
      virus. The differential diagnosis of viral encephalitis includes other infections 
      and immune-mediated inflammatory central nervous system disorders.
CI  - Copyright (c) 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora 
      Ltda. All rights reserved.
FAU - Costa, Bruna Klein da
AU  - Costa BKD
AD  - Pontificia Universidade Catolica do Rio Grande do Sul (PUC-RS), Hospital Sao 
      Lucas, Departamento de Neurologia, Porto Alegre, RS, Brazil; Pontificia 
      Universidade Catolica do Rio Grande do Sul (PUC-RS), Escola de Medicina, Porto 
      Alegre, RS, Brazil. Electronic address: brunakleinc@gmail.com.
FAU - Sato, Douglas Kazutoshi
AU  - Sato DK
AD  - Pontificia Universidade Catolica do Rio Grande do Sul (PUC-RS), Hospital Sao 
      Lucas, Departamento de Neurologia, Porto Alegre, RS, Brazil; Pontificia 
      Universidade Catolica do Rio Grande do Sul (PUC-RS), Escola de Medicina, Porto 
      Alegre, RS, Brazil; Pontificia Universidade Catolica do Rio Grande do Sul 
      (PUC-RS), Instituto do Cerebro, Porto Alegre, RS, Brazil.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190909
PL  - Brazil
TA  - J Pediatr (Rio J)
JT  - Jornal de pediatria
JID - 2985188R
SB  - IM
MH  - Adolescent
MH  - Brazil
MH  - Child
MH  - Cytomegalovirus
MH  - *Encephalitis, Viral/diagnosis/therapy
MH  - Herpesvirus 4, Human
MH  - Herpesvirus 6, Human
MH  - Humans
MH  - Zika Virus
MH  - Zika Virus Infection
PMC - PMC9431993
OTO - NOTNLM
OT  - Diagnosis
OT  - Diagnostico
OT  - Encefalite viral
OT  - Tratamento
OT  - Treatment
OT  - Viral encephalitis
EDAT- 2019/09/13 06:00
MHDA- 2021/01/12 06:00
PMCR- 2019/09/09
CRDT- 2019/09/13 06:00
PHST- 2019/07/10 00:00 [received]
PHST- 2019/07/18 00:00 [accepted]
PHST- 2019/09/13 06:00 [pubmed]
PHST- 2021/01/12 06:00 [medline]
PHST- 2019/09/13 06:00 [entrez]
PHST- 2019/09/09 00:00 [pmc-release]
AID - S0021-7557(19)30429-2 [pii]
AID - 10.1016/j.jped.2019.07.006 [doi]
PST - ppublish
SO  - J Pediatr (Rio J). 2020 Mar-Apr;96 Suppl 1(Suppl 1):12-19. doi: 
      10.1016/j.jped.2019.07.006. Epub 2019 Sep 9.