PMID- 31514015
OWN - NLM
STAT- MEDLINE
DCOM- 20210621
LR  - 20210621
IS  - 1532-8430 (Electronic)
IS  - 0022-0736 (Linking)
VI  - 57
DP  - 2019 Nov-Dec
TI  - Non-invasive electrocardiographic imaging in patients with idiopathic premature 
      ventricular contractions from the right ventricular outflow tract: New insights 
      into arrhythmia substrate.
PG  - 69-76
LID - S0022-0736(19)30496-0 [pii]
LID - 10.1016/j.jelectrocard.2019.08.046 [doi]
AB  - AIMS: The aim of this study was to use non-invasive electrocardiographic imaging 
      (ECGI) to study the electrophysiological properties of right ventricular outflow 
      tract (RVOT) in patients with frequent premature ventricular contractions (PVCs) 
      from the RVOT and in controls. METHODS: ECGI is a combined application of body 
      surface electrocardiograms and computed tomography or magnetic resonance imaging 
      data. Unipolar electrograms are reconstructed on the epicardial and endocardial 
      surfaces. Activation time (AT) was defined as the time of maximal negative slope 
      of the electrogram (EGM) during QRS, recovery time (RT) as the time of maximal 
      positive slope of the EGM during T wave, Activation recovery interval (ARI) was 
      defined as the difference between RT and AT. ARI dispersion (Delta ARI) and RT 
      dispersion (Delta RT) were calculated as the difference between maximal and minimal 
      ARI and RT respectively. We evaluated those parameters in patients with frequent 
      PVCs from the RVOT, defined as >10.000 per 24 h, and in a control group. RESULTS: 
      We studied 7 patients with frequent RVOT PVCs and 17 controls. Patients with PVCs 
      from the RVOT had shorter median RT than controls, in the endocardium and in the 
      epicardium, respectively 380 (239-397) vs 414 (372-448) ms, p = 0.047 and 275 
      (236-301) vs 330 (263-418) ms, p = 0.047. The dispersion of ARI and of RT in the 
      epicardium was higher than in controls, Delta ARI of 145 (68-216) vs 17 (3-48) ms, 
      p = 0.001 and Delta RT of 201 (160-235) vs 115 (65-177), p = 0.019. CONCLUSION: In 
      this group of patients we found a shorter median RT in the endocardium and in the 
      epicardium of the RVOT and a higher dispersion of the ARI and RT across the 
      epicardium in patients with PVCs from the RVOT when comparing to controls.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Parreira, Leonor
AU  - Parreira L
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal. Electronic address: 
      leonor.parreira@gmail.com.
FAU - Carmo, Pedro
AU  - Carmo P
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Adragao, Pedro
AU  - Adragao P
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Pinho, Joana
AU  - Pinho J
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Budanova, Margarita
AU  - Budanova M
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Zubarev, Stepan
AU  - Zubarev S
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Cavaco, Diogo
AU  - Cavaco D
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Marinheiro, Rita
AU  - Marinheiro R
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Carmo, Joao
AU  - Carmo J
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Costa, Francisco
AU  - Costa F
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Marques, Hugo
AU  - Marques H
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
FAU - Goncalves, Pedro
AU  - Goncalves P
AD  - Hospital Luz Lisboa, Av Lusiada 1500-650, Lisboa, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20190831
PL  - United States
TA  - J Electrocardiol
JT  - Journal of electrocardiology
JID - 0153605
SB  - IM
MH  - *Catheter Ablation
MH  - Electrocardiography
MH  - Endocardium
MH  - Heart Ventricles
MH  - Humans
MH  - *Tachycardia, Ventricular/surgery
MH  - *Ventricular Premature Complexes/diagnosis/surgery
OTO - NOTNLM
OT  - ARI
OT  - Catheter ablation
OT  - Idiopathic premature ventricular contractions
OT  - Non-invasive electrocardiographic imaging
EDAT- 2019/09/13 06:00
MHDA- 2021/06/22 06:00
CRDT- 2019/09/13 06:00
PHST- 2019/06/24 00:00 [received]
PHST- 2019/08/19 00:00 [revised]
PHST- 2019/08/30 00:00 [accepted]
PHST- 2019/09/13 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/09/13 06:00 [entrez]
AID - S0022-0736(19)30496-0 [pii]
AID - 10.1016/j.jelectrocard.2019.08.046 [doi]
PST - ppublish
SO  - J Electrocardiol. 2019 Nov-Dec;57:69-76. doi: 10.1016/j.jelectrocard.2019.08.046. 
      Epub 2019 Aug 31.