PMID- 31514058
OWN - NLM
STAT- MEDLINE
DCOM- 20200731
LR  - 20200731
IS  - 1778-3585 (Electronic)
IS  - 0924-9338 (Linking)
VI  - 62
DP  - 2019 Oct
TI  - Clinical and functional ultra-long-term outcome of patients with a clinical high 
      risk (CHR) for psychosis.
PG  - 30-37
LID - S0924-9338(19)30139-7 [pii]
LID - 10.1016/j.eurpsy.2019.08.005 [doi]
AB  - BACKGROUND: Few studies have followed up patients with a clinical high risk (CHR) 
      for psychosis for more than 2-3 years. We aimed to investigate the rates and 
      baseline predictors for remission from CHR and transition to psychosis over a 
      follow-up period of up to 16 years. Additionally, we examined the clinical and 
      functional long-term outcome of CHR patients who did not transition. METHODS: We 
      analyzed the long-term course of CHR patients that had been included in the 
      longitudinal studies "Fruherkennung von Psychosen" (FePsy) or "Bruderholz" (BHS). 
      Those patients who had not transitioned to psychosis during the initial follow-up 
      periods (2/5 years), were invited for additional follow-ups. RESULTS: Originally, 
      255 CHR patients had been included. Of these, 47 had transitioned to psychosis 
      during the initial follow-ups. Thus, 208 were contacted for the long-term 
      follow-up, of which 72 (34.6%) participated. From the original sample of 255, 
      26%, 31%, 35%, and 38% were estimated to have transitioned after 3, 5, 10, and 16 
      years, respectively, and 51% had remitted from their high risk status at the 
      latest follow-up. Better psychosocial functioning at baseline was associated with 
      a higher rate of remission. Of the 72 CHR patients re-assessed at long-term 
      follow-up, 60 had not transitioned, but only 28% of those were fully recovered 
      clinically and functionally. CONCLUSIONS: Our study shows the need for follow-ups 
      and clinical attention longer than the usual 2-3 years as there are several CHR 
      patients with later transitions and only a minority of CHR those without 
      transition fully recovers.
CI  - Copyright (c) 2019 Elsevier Masson SAS. All rights reserved.
FAU - Beck, Katharina
AU  - Beck K
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland; University of Basel, Division of Clinical 
      Psychology and Epidemiology, Department of Psychology, Basel, Switzerland.
FAU - Studerus, Erich
AU  - Studerus E
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland; University of Basel, Department of Psychology, 
      Division of Developmental and Personality Psychology, Basel, Switzerland.
FAU - Andreou, Christina
AU  - Andreou C
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland.
FAU - Egloff, Laura
AU  - Egloff L
AD  - University of Basel, Division of Clinical Psychology and Epidemiology, Department 
      of Psychology, Basel, Switzerland; Department of Psychiatry, University of Basel 
      Psychiatric Hospital, Basel, Switzerland.
FAU - Leanza, Letizia
AU  - Leanza L
AD  - University of Basel Psychiatric Hospital, Center for Gender Research and Early 
      Detection, Basel, Switzerland; University of Basel, Division of Clinical 
      Psychology and Epidemiology, Department of Psychology, Basel, Switzerland.
FAU - Simon, Andor E
AU  - Simon AE
AD  - University Hospital of Psychiatry and Psychotherapy, University of Bern, 
      Switzerland; Specialized Early Psychosis Outpatient Service for Adolescents and 
      Young Adults, Department of Psychiatry, Bruderholz, Switzerland.
FAU - Borgwardt, Stefan
AU  - Borgwardt S
AD  - Department of Psychiatry, University of Basel Psychiatric Hospital, Basel, 
      Switzerland.
FAU - Riecher-Rossler, Anita
AU  - Riecher-Rossler A
AD  - University of Basel, Basel, Switzerland. Electronic address: 
      anita.riecher-roessler@unibas.ch.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190909
PL  - England
TA  - Eur Psychiatry
JT  - European psychiatry : the journal of the Association of European Psychiatrists
JID - 9111820
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Psychotic Disorders/*psychology
MH  - Young Adult
OTO - NOTNLM
OT  - At-risk mental state
OT  - Comorbidity
OT  - Functioning
OT  - Recovery
OT  - Remission
OT  - Symptomatology
EDAT- 2019/09/13 06:00
MHDA- 2020/08/01 06:00
CRDT- 2019/09/13 06:00
PHST- 2019/05/14 00:00 [received]
PHST- 2019/08/15 00:00 [revised]
PHST- 2019/08/26 00:00 [accepted]
PHST- 2019/09/13 06:00 [pubmed]
PHST- 2020/08/01 06:00 [medline]
PHST- 2019/09/13 06:00 [entrez]
AID - S0924-9338(19)30139-7 [pii]
AID - 10.1016/j.eurpsy.2019.08.005 [doi]
PST - ppublish
SO  - Eur Psychiatry. 2019 Oct;62:30-37. doi: 10.1016/j.eurpsy.2019.08.005. Epub 2019 
      Sep 9.