PMID- 31514774
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20190913
LR  - 20190913
IS  - 0009-4293 (Print)
IS  - 0009-4293 (Linking)
VI  - 73
IP  - 9
DP  - 2019 Sep 18
TI  - Environmental Metrics to Drive a Cultural Change: Our Green Eco-Label.
PG  - 730-736
LID - 10.2533/chimia.2019.730 [doi]
AB  - A novel Green Chemistry Process Scorecard was developed to assess the 
      environmental impact of chemical production processes to manufacture the Active 
      Pharmaceutical Ingredients (API) within our portfolio. These new metrics not only 
      cover the resource consumption from the overall chemical synthesis, but also 
      consider the use of Substances of Concern and the number of chemical 
      transformations. The Process Mass Intensity (PMI), i.e. the ratio of accumulated 
      kilogram quantities of materials per kilogram of API, is used to quantify the 
      resource consumption. An 'eco-label' for specific APIs is used to visualize the 
      environmental impact from their chemical synthesis. For an overview of the 
      environmental impact of a complete product portfolio, a diagram of PMI or total 
      waste quantity vs. the number of synthetic steps can also be used as a 
      visualization tool to identify chemical syntheses with a high need for process 
      improvements. Implementation of this process led to a dramatic change of mindset 
      within the organization. It now supports and drives the decision making at 
      Chemical and Analytical Development, and helps to trigger new projects more 
      readily for sustainability reasons.
FAU - Onken, Ulrich
AU  - Onken U
AD  - Novartis Chemical and Analytical Development, CH-4002 Basel.
FAU - Koettgen, Agnieszka
AU  - Koettgen A
AD  - Novartis Chemical and Analytical Development, CH-4002 Basel.
FAU - Scheidat, Holger
AU  - Scheidat H
AD  - Novartis Chemical and Analytical Development, CH-4002 Basel.
FAU - Schueepp, Patrick
AU  - Schueepp P
AD  - Novartis Chemical and Analytical Development, CH-4002 Basel.
FAU - Gallou, Fabrice
AU  - Gallou F
AD  - Novartis Chemical and Analytical Development, CH-4002 Basel;, Email: 
      fabrice.gallou@novartis.com.
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Chimia (Aarau)
JT  - Chimia
JID - 0373152
SB  - IM
EDAT- 2019/09/14 06:00
MHDA- 2019/09/14 06:01
CRDT- 2019/09/14 06:00
PHST- 2019/09/14 06:00 [entrez]
PHST- 2019/09/14 06:00 [pubmed]
PHST- 2019/09/14 06:01 [medline]
AID - 10.2533/chimia.2019.730 [doi]
PST - ppublish
SO  - Chimia (Aarau). 2019 Sep 18;73(9):730-736. doi: 10.2533/chimia.2019.730.