PMID- 31514985
OWN - NLM
STAT- MEDLINE
DCOM- 20200204
LR  - 20200204
IS  - 1875-5364 (Electronic)
IS  - 1875-5364 (Linking)
VI  - 17
IP  - 7
DP  - 2019 Jul
TI  - Hematopoietic effect of small molecular fraction of Polygoni multiflori Radix 
      Praeparata in cyclophosphamide-induced anemia mice.
PG  - 535-544
LID - S1875-5364(19)30075-5 [pii]
LID - 10.1016/S1875-5364(19)30075-5 [doi]
AB  - The aim of this study is to investigate the protective effects of a small 
      molecular fraction (SMF) of Polygoni multiflori Radix Praeparata (PMRP) in a 
      cyclophosphamide (CTX) induced anemia mouse model. Small molecular fraction of 
      PMRP was prepared and identified by high-performance liquid 
      chromatography-quadrupole time-of-flight mass spectrometry (HPLC-Q-TOF-MS). In 
      pharmacology, we examined the peripheral hemogram and thymus and spleen index. 
      The content of granulocyte-macrophage colony-stimulating factor (GM-CSF) in serum 
      was mensurated by enzyme-linked immunosorbent assay (ELISA); The level of 
      superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (T-AOC), 
      and malondialdehyde (MDA) in serum and spleen tissue homogenate were detected, 
      and glutathione peroxidase (GSH-PX) was assayed in spleen. The results show that 
      SMF can significantly accelerate the recovery of peripheral hemogram, increase 
      the activity of antioxidant enzymes and GM-CSF in serum and spleen. SMF also 
      increases the number of spleen cells, improves bone marrow pathology. In 
      conclusion, the SMF of PMRP promoted the recovery of hematopoietic function in a 
      CTX-induced anemia mouse, which can support SMF to be used as an adjunct to 
      chemotherapy to counteract its side effects.
CI  - Copyright (c) 2019 China Pharmaceutical University. Published by Elsevier B.V. All 
      rights reserved.
FAU - Zhu, Li-Li
AU  - Zhu LL
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China 
      Pharmaceutical University, Nanjing 210009, China.
FAU - Fan, Luo-Di
AU  - Fan LD
AD  - Infinitus Chinese Herbal Immunity Research Centre, Infinitus (China) Company 
      Limited., Guangzhou 510663, China.
FAU - Hu, Ming-Hua
AU  - Hu MH
AD  - Infinitus Chinese Herbal Immunity Research Centre, Infinitus (China) Company 
      Limited., Guangzhou 510663, China.
FAU - Ma, Fang-Li
AU  - Ma FL
AD  - Infinitus Chinese Herbal Immunity Research Centre, Infinitus (China) Company 
      Limited., Guangzhou 510663, China.
FAU - Qi, Jin
AU  - Qi J
AD  - Jiangsu Key Laboratory of TCM Evaluation and Translational Research, China 
      Pharmaceutical University, Nanjing 210009, China. Electronic address: 
      qijin2006@163.com.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin J Nat Med
JT  - Chinese journal of natural medicines
JID - 101504416
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
RN  - 8N3DW7272P (Cyclophosphamide)
SB  - IM
MH  - Anemia/chemically induced/*drug therapy
MH  - Animals
MH  - Antioxidants/metabolism
MH  - Cyclophosphamide/*toxicity
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/blood
MH  - Hematopoiesis/*drug effects
MH  - Male
MH  - Mice, Inbred ICR
MH  - Molecular Structure
MH  - Phytotherapy
MH  - Plant Extracts/chemistry/*pharmacology/*therapeutic use
MH  - Plant Roots/chemistry
MH  - Polygonum/*chemistry
MH  - Spleen/drug effects/metabolism/pathology
MH  - Thymus Gland/drug effects/metabolism
OTO - NOTNLM
OT  - Cyclophosphamide
OT  - Hemopoiesis
OT  - Polygoni multiflori Radix Praeparata
OT  - Small molecular fraction
EDAT- 2019/09/14 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/09/14 06:00
PHST- 2019/05/06 00:00 [received]
PHST- 2019/09/14 06:00 [entrez]
PHST- 2019/09/14 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
AID - S1875-5364(19)30075-5 [pii]
AID - 10.1016/S1875-5364(19)30075-5 [doi]
PST - ppublish
SO  - Chin J Nat Med. 2019 Jul;17(7):535-544. doi: 10.1016/S1875-5364(19)30075-5.