PMID- 31516856
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2228-7930 (Print)
IS  - 2228-7949 (Electronic)
IS  - 2228-7930 (Linking)
VI  - 9
IP  - 5
DP  - 2019 Sep-Oct
TI  - Curcumin effects on myeloperoxidase, interleukin-18 and matrix 
      metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A 
      randomized clinical trial.
PG  - 428-435
AB  - OBJECTIVE: Inflammation along with oxidative stress plays an important role in 
      the development, progression, instability and rupture of coronary atherosclerotic 
      plaques. Several studies introduced curcumin (diferuloylmethane) as a wonderful 
      chemical in Curcuma longa (turmeric) with appropriate anti-inflammatory and 
      antioxidant effects. The effect of curcumin on inflammatory biomarkers was 
      assessed in several clinical trials. This study was designed to evaluate the 
      effect of curcumin on three pro-inflammatory biomarkers in patients with unstable 
      angina. MATERIALS AND METHODS: Forty patients with unstable angina who met the 
      inclusion criteria, participated in this double-blind randomized clinical trial. 
      Patients were randomly divided into two groups. The patients in the treatment 
      group received nanocurcumin 80 mg per day for 5 days and the control group 
      received placebo 80 mg per day for five days. Blood samples were obtained before 
      the administration, and also 1, 2 and 4 days after taking the treatment. Serum 
      concentrations of Myeloperoxidase (MPO), matrix metalloproteinase-9 (MMP-9) and 
      interleukin 18 (IL-18) biomarkers were measured by ELISA. RESULTS: There was no 
      significant difference in concentration of these biomarkers before the 
      administration and 1, 2 and 4 days after the start of the trial, between the two 
      groups; however, the concentration of IL-18 on the first day significantly varied 
      between the groups. CONCLUSION: Based on the findings of this study, 
      administration of nanocurcumin capsules at the dose of 80 mg per day for 5 days, 
      did not significantly decrease inflammatory biomarkers in patients with unstable 
      angina.
FAU - Mohammad Pour, Amir Hooshang
AU  - Mohammad Pour AH
AD  - Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of 
      Medical Sciences, Mashhad, Iran.
AD  - Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Equal first author.
FAU - Dastani, Mostafa
AU  - Dastani M
AD  - Department of Cardiology, Ghaem Hospital, School of Medicine, Mashhad University 
      of Medical Sciences, Mashhad, Iran.
AD  - Equal first author.
FAU - Salari, Roshanak
AU  - Salari R
AD  - Department of Clinical Persian Pharmacy, School of Persian and Complementary 
      Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Radbin, Sohrab
AU  - Radbin S
AD  - Pharmaceutical Research Center, Institute of Pharmaceutical Technology, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Mehri, Soghra
AU  - Mehri S
AD  - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Ghorbani, Maryam
AU  - Ghorbani M
AD  - Department of Pharmacology and Toxicology, School of Pharmacy, Baqiyatallah 
      University of Medical Sciences, Tehran, Iran.
FAU - Karimani, Asieh
AU  - Karimani A
AD  - Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Salari, Masoumeh
AU  - Salari M
AD  - Department of Internal Medicine, Ghaem Hospital, School of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Avicenna J Phytomed
JT  - Avicenna journal of phytomedicine
JID - 101586220
PMC - PMC6727433
OTO - NOTNLM
OT  - Curcumin
OT  - Interlukein-18 Myeloperoxidase
OT  - Matrix metalloproteinase-9
OT  - Unstable angina
COIS- The authors have no conflicts of interest.
EDAT- 2019/09/14 06:00
MHDA- 2019/09/14 06:01
PMCR- 2019/09/01
CRDT- 2019/09/14 06:00
PHST- 2019/09/14 06:00 [entrez]
PHST- 2019/09/14 06:00 [pubmed]
PHST- 2019/09/14 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - AJP-9-428 [pii]
PST - ppublish
SO  - Avicenna J Phytomed. 2019 Sep-Oct;9(5):428-435.