PMID- 31516857
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2228-7930 (Print)
IS  - 2228-7949 (Electronic)
IS  - 2228-7930 (Linking)
VI  - 9
IP  - 5
DP  - 2019 Sep-Oct
TI  - Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers 
      levels in patients with type 2 diabetes mellitus: a randomized double-blind 
      clinical trial.
PG  - 436-445
AB  - OBJECTIVE: Type 2 diabetes mellitus (T2DM) is one of the most common health 
      problems worldwide. Studies have shown that saffron and its derivatives may have 
      therapeutic potentials in T2DM through reducing plasma glucose. The present study 
      aimed to evaluate the effects of saffron extract on serum anti-inflammatory and 
      antioxidant variables in T2DM patients. MATERIALS AND METHODS: This was a 
      double-blind randomized clinical trial conducted on 64 T2DM patients. 
      Participants received either 15 mg of saffron or placebo capsules (two pills per 
      day) for 3 months. Anthropometric indices, homocysteine, serum anti-inflammatory 
      and antioxidant variables and dietary intake were assessed pre- and 
      post-intervention. RESULTS: After 3 months of treatment, interleukin-6 (IL-6), 
      and tumor necrosis factor (TNF-alpha) increased significantly in both group (p<0.05). 
      No significant differences were observed for total antioxidant capacity (TAC), 
      malondialdehyde (MDA), high sensitivity C-reactive protein (hs-CRP) and 
      interleukin 10(IL-10) after the treatment period (p>0.05). Homocysteine decteased 
      significantly in control group (p<0.05). CONCLUSION: Our results showed no 
      improvement in homocystein levels, antioxidant status and inflammatory biomarkers 
      in T2DM patients after treatment with saffron.
FAU - Shahbazian, Hajieh
AU  - Shahbazian H
AD  - Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Moravej Aleali, Armaghan
AU  - Moravej Aleali A
AD  - Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Amani, Reza
AU  - Amani R
AD  - Department of Clinical Nutrition, School of Nutrition & Food Science, Food 
      security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Namjooyan, Foroogh
AU  - Namjooyan F
AD  - Department of Pharmacognosy, School of Pharmacy, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
FAU - Cheraghian, Bahman
AU  - Cheraghian B
AD  - Department of Epidemiology & Biostatistics, School of Public Health, Ahvaz 
      Jundishapur University of Medical Sciences, Ahvaz, Iran.
FAU - Latifi, Seyed Mahmoud
AU  - Latifi SM
AD  - Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Bahrainian, Sara
AU  - Bahrainian S
AD  - Aerosol Research Laboratory, Department of Pharmaceutics, School of Pharmacy, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Ghadiri, Ataallah
AU  - Ghadiri A
AD  - Cellular and molecular research center, Department of Immunology, School of 
      Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Avicenna J Phytomed
JT  - Avicenna journal of phytomedicine
JID - 101586220
PMC - PMC6727435
OTO - NOTNLM
OT  - Antioxidant
OT  - Biomarkers
OT  - Inflammatory
OT  - Saffron
OT  - Type 2 Diabetes Mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2019/09/14 06:00
MHDA- 2019/09/14 06:01
PMCR- 2019/09/01
CRDT- 2019/09/14 06:00
PHST- 2019/09/14 06:00 [entrez]
PHST- 2019/09/14 06:00 [pubmed]
PHST- 2019/09/14 06:01 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - AJP-9-436 [pii]
PST - ppublish
SO  - Avicenna J Phytomed. 2019 Sep-Oct;9(5):436-445.