PMID- 31517031
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220721
IS  - 2352-8737 (Electronic)
IS  - 2352-8737 (Linking)
VI  - 5
DP  - 2019
TI  - Chinese herbal medicine Qinggongshoutao for the treatment of amnestic mild 
      cognitive impairment: A 52-week randomized controlled trial.
PG  - 441-449
LID - 10.1016/j.trci.2019.03.001 [doi]
AB  - INTRODUCTION: This randomized, double-blind trial aimed to test effect of a 
      Chinese herbal medicine, Qinggongshoutao (QGST) pill, on the cognition and 
      progression of amnestic mild cognitive impairment (aMCI). METHODS: Patients with 
      aMCI were randomly assigned to receive QGST, Ginkgo biloba extract, or placebo 
      for 52 weeks. The primary outcome measures were progression to possible or 
      probable Alzheimer's disease (AD) and change in Alzheimer's Disease Assessment 
      Scale-cognitive subscale scores; secondary outcome measures included assessments 
      for cognition and function. RESULTS: Total 350 patients were enrolled, possible 
      or probable AD developed in 10. There were significant differences in the 
      probability of progression to AD in the QGST group (1.15%) compared with placebo 
      group (10%). There was significant difference in Alzheimer's Disease Assessment 
      Scale-cognitive subscale scores in favor of QGST over the placebo group. 
      Secondary outcome measure (Mini-Mental State Examination) also showed benefit in 
      QGST at end point. DISCUSSION: In patients with aMCI, QGST showed lower AD 
      progression rate than placebo at 8.85%, and may have benefit on global cognition.
FAU - Tian, Jinzhou
AU  - Tian J
AD  - Neurology Centre, Dongzhimen Hospital, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Shi, Jing
AU  - Shi J
AD  - Neurology Centre, Dongzhimen Hospital, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Wei, Mingqing
AU  - Wei M
AD  - Neurology Centre, Dongzhimen Hospital, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Ni, Jingnian
AU  - Ni J
AD  - Neurology Centre, Dongzhimen Hospital, Beijing University of Chinese Medicine, 
      Beijing, China.
FAU - Fang, Zhiyong
AU  - Fang Z
AD  - Department of Neurology, Xiangyang Hospital of Traditional Chinese Medicine, 
      Xiangyang, Henan Province, China.
FAU - Gao, Jinyu
AU  - Gao J
AD  - Department of Neurology, Tangshan Hospital of Traditional Chinese Medicine, 
      Tangshan, Hebei Province, China.
FAU - Wang, Heng
AU  - Wang H
AD  - Department of Neurology, Tianjin Nankai Hospital, Tianjin, China.
FAU - Yao, Hongjun
AU  - Yao H
AD  - Department of Neurology, Yuncheng Central Hospital, Yuncheng, Shanxi Province, 
      China.
FAU - Zhang, Jintao
AU  - Zhang J
AD  - Department of Neurology, 88th Hospital of PLA, Taian, Shandong Province, China.
FAU - Li, Juntao
AU  - Li J
AD  - Department of Neurology, Handan Central Hospital, Handan, Hebei Province, China.
FAU - Min, Min
AU  - Min M
AD  - Department of Neurology, Tengzhou Central People's Hospital, Zaozhuang, Shandong 
      Province, China.
FAU - Su, Likai
AU  - Su L
AD  - Department of Neurology, Affiliated Hospital of Hebei University, Shijiazhuang, 
      Hebei Province, China.
FAU - Sun, Xiuqiao
AU  - Sun X
AD  - Department of Neurology, First Hospital of Hebei Medical University, 
      Shijiazhuang, Hebei Province, China.
FAU - Wang, Baoai
AU  - Wang B
AD  - Department of Neurology, Shanxi Fenyang Hospital, Lvliang, Shanxi Province, 
      China.
FAU - Wang, Baoshen
AU  - Wang B
AD  - Department of Neurology, Luohe Hospital of Chinese Medicine, Luohe, Henan 
      Province, China.
FAU - Yang, Faming
AU  - Yang F
AD  - Department of Neurology, Third Hospital of Shanxi Medical College, Taiyuan, 
      Shanxi Province, China.
FAU - Zou, Yong
AU  - Zou Y
AD  - Department of Integrated TCM & Western Medicine, Qindao University Medical 
      College Affiliated Yantai Yuhuangding Hospital, Yantai, Shandong Province, China.
FAU - Hu, Yueqiang
AU  - Hu Y
AD  - Department of Neurology, First Affiliated Hospital of Guangxi University of 
      Chinese Medicine, Nanning, Guangxi Province, China.
FAU - Lin, Yaming
AU  - Lin Y
AD  - Department of Neurology, Yunnan Provincial Hospital of Traditional Chinese 
      Medicine, Kunming, Yunnan Province, China.
FAU - Xu, Guangyin
AU  - Xu G
AD  - Department of Neurology, The People's Hospital of Linyi, Linyi, Shandong 
      Province, China.
FAU - Li, Kang
AU  - Li K
AD  - Department of Health Statistics Harbin Medical University, Harbin, Heilongjiang 
      Province, China.
FAU - Li, Lei
AU  - Li L
AD  - Pharmaceutical Research and Clinical Evaluation Center of China Association of 
      Traditional Chinese Medicine, Beijing, China.
FAU - Zhen, Hui
AU  - Zhen H
AD  - Pharmaceutical Research and Clinical Evaluation Center of China Association of 
      Traditional Chinese Medicine, Beijing, China.
FAU - Xu, Jinyan
AU  - Xu J
AD  - Beijing Kangpaite Pharmaceutical Co., Ltd, Beijing, China.
FAU - Chen, Keji
AU  - Chen K
AD  - Institute of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical 
      Sciences, Beijing, China.
FAU - Wang, Yongyan
AU  - Wang Y
AD  - Institute of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, Beijing China.
CN  - CHARM study group
LA  - eng
PT  - Journal Article
DEP - 20190904
PL  - United States
TA  - Alzheimers Dement (N Y)
JT  - Alzheimer's & dementia (New York, N. Y.)
JID - 101650118
EIN - Alzheimers Dement (N Y). 2022 Jul 17;8(1):e12266. PMID: 35860444
PMC - PMC6732732
OTO - NOTNLM
OT  - Amnestic mild cognitive impairment
OT  - Efficacy
OT  - Herbal medicine
OT  - Randomized clinical trial
EDAT- 2019/09/14 06:00
MHDA- 2019/09/14 06:01
PMCR- 2019/09/04
CRDT- 2019/09/14 06:00
PHST- 2019/09/14 06:00 [entrez]
PHST- 2019/09/14 06:00 [pubmed]
PHST- 2019/09/14 06:01 [medline]
PHST- 2019/09/04 00:00 [pmc-release]
AID - S2352-8737(19)30011-3 [pii]
AID - 10.1016/j.trci.2019.03.001 [doi]
PST - epublish
SO  - Alzheimers Dement (N Y). 2019 Sep 4;5:441-449. doi: 10.1016/j.trci.2019.03.001. 
      eCollection 2019.