PMID- 31517428 OWN - NLM STAT- MEDLINE DCOM- 20210329 LR - 20210329 IS - 1097-0193 (Electronic) IS - 1065-9471 (Print) IS - 1065-9471 (Linking) VI - 41 IP - 1 DP - 2020 Jan TI - Reconfiguration of dynamic large-scale brain network functional connectivity in generalized tonic-clonic seizures. PG - 67-79 LID - 10.1002/hbm.24787 [doi] AB - An increasing number of studies in patients with generalized tonic-clonic seizures (GTCS) have reported the alteration of functional connectivity (FC) in many brain networks. However, little is known about the underlying temporal variability of FC in large-scale brain functional networks in patients. Recently, dynamic FC could provide novel insight into the physiological mechanisms in the brain. Here, we recruited 63 GTCS and 65 age- and sex-matched healthy controls. Dynamic FC approaches were used to evaluate alterations in the temporal variability of FC in patients at the region- and network-levels. In addition, two kinds of brain templates (>10(2) and > 10(3) regions) and two kinds of temporal variability FC approaches were adopted to verify the stability of the results. Patients showed increased FC variability in regions of the default mode network (DMN), ventral attention network (VAN) and motor-related areas. The DAN, VAN, and DMN illustrated enhanced FC variability at the within-network level. In addition, increased FC variabilities between networks were found between the DMN and cognition-related networks, including the VAN, dorsal attention network and frontal-parietal network in GTCS. Meanwhile, the alterations in FC variability were relatively consistent across different methods and templates. Therefore, the consistent alteration of FC variability would reflect a dynamic restructuring of the large-scale brain networks in patients with GTCS. Overly frequent information communication among cognition-related networks, especially in the DMN, might play a role in the epileptic activity and/or cognitive dysfunction in patients. CI - (c) 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. FAU - Jia, Xiaoyan AU - Jia X AUID- ORCID: 0000-0002-3730-6877 AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Xie, Yan AU - Xie Y AD - Neurology Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. FAU - Dong, Debo AU - Dong D AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Pei, Haonan AU - Pei H AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Jiang, Sisi AU - Jiang S AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Ma, Shuai AU - Ma S AD - Neurology Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. FAU - Huang, Yang AU - Huang Y AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Zhang, Xingxing AU - Zhang X AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Wang, Yuhong AU - Wang Y AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Zhu, Qiong AU - Zhu Q AD - Neurology Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. FAU - Zhang, Yanan AU - Zhang Y AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Yao, Dezhong AU - Yao D AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. FAU - Yu, Liang AU - Yu L AD - Neurology Department, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China. FAU - Luo, Cheng AU - Luo C AUID- ORCID: 0000-0003-0524-5886 AD - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, High-Field Magnetic Resonance Brain Imaging Key Laboratory of Sichuan Province, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190913 PL - United States TA - Hum Brain Mapp JT - Human brain mapping JID - 9419065 SB - IM MH - Adult MH - *Connectome MH - Epilepsy/diagnostic imaging/*physiopathology MH - Humans MH - Magnetic Resonance Imaging MH - Nerve Net/diagnostic imaging/*physiopathology MH - Seizures/diagnostic imaging/*physiopathology PMC - PMC7267969 OTO - NOTNLM OT - epilepsy OT - functional connectivity OT - functional magnetic resonance imaging OT - generalized tonic-clonic seizures OT - temporal variability EDAT- 2019/09/14 06:00 MHDA- 2021/03/30 06:00 PMCR- 2019/09/13 CRDT- 2019/09/14 06:00 PHST- 2019/03/30 00:00 [received] PHST- 2019/08/02 00:00 [revised] PHST- 2019/08/26 00:00 [accepted] PHST- 2019/09/14 06:00 [pubmed] PHST- 2021/03/30 06:00 [medline] PHST- 2019/09/14 06:00 [entrez] PHST- 2019/09/13 00:00 [pmc-release] AID - HBM24787 [pii] AID - 10.1002/hbm.24787 [doi] PST - ppublish SO - Hum Brain Mapp. 2020 Jan;41(1):67-79. doi: 10.1002/hbm.24787. Epub 2019 Sep 13.