PMID- 31517610
OWN - NLM
STAT- MEDLINE
DCOM- 20191017
LR  - 20191017
IS  - 1336-0329 (Electronic)
IS  - 1210-0668 (Linking)
VI  - 52
IP  - 4
DP  - 2018 Oct 1
TI  - Association between adiponectin rs17300539 and rs266729 gene polymorphisms with 
      serum adiponectin level in an Iranian diabetic/pre-diabetic population.
PG  - 176-184
LID - /j/enr.2018.52.issue-4/enr-2018-0022/enr-2018-0022.xml [pii]
LID - 10.2478/enr-2018-0022 [doi]
AB  - OBJECTIVE: Adiponectin is an adipokine that is mostly secreted from adipose 
      tissues and has a significant role in the improvement of insulin resistant and 
      type 2 diabetes mellitus (T2DM). This study is conducted to examine the 
      association of rs17300539 and rs266729 with T2DM and serum adiponectin level in 
      Iranian population. METHOD: A case-control study was conducted on 80 individuals 
      with fasting plasma glucose (FPG) >100 (mg/dl) as diabetic-pre-diabetic group, 
      and 80 individuals with fasting plasma glucose 70-100 (mg/dl) as control group. 
      DNA extraction was done on samples and genotyping method was performed by 
      PCR-RFLP. RESULT: The frequency of GA genotype in rs17300539 
      (diabetic/pre-diabetic 35.5%, control 11.3%, (OR [95%CI]=4.18[1.8-9.6]; p=0.001) 
      and allele A (diabetic/pre-diabetic 31%, control 9%, (OR [95% CI]=4.67[2-10.7]) 
      was significantly more in diabetic/pre-diabetic group compared to control group. 
      The difference in the genotype frequency for rs266729 in diabetic group compared 
      to that in control was not significant. The levels of adiponectin in diabetic 
      cases had no difference compared to the control group in both polymorphisms. The 
      rs266729 was not associated with any metabolic parameter except waist 
      circumference (p=0.03), however, rs17300539 shows association only with fasting 
      plasma glucose, triglyceride, and total cholesterol (p=0.007, 0.039, 0.0032, 
      respectively). CONCLUSION: Our findings showed that there is an association 
      between rs17300539 with the increase of T2DM but rs266729 showed no association 
      with the risk of T2DM. Allele A of rs17300539 increased the risk of diabetes. 
      There is no association between adiponectin level and both polymorphisms.
FAU - Karimi, Helma
AU  - Karimi H
AD  - Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, 
      Iran.
FAU - Nezhadali, Masoumeh
AU  - Nezhadali M
AD  - Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, 
      Iran.
FAU - Hedayati, Mehdi
AU  - Hedayati M
AD  - Cellular and Molecular Endocrine Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Endocr Regul
JT  - Endocrine regulations
JID - 9112018
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
SB  - IM
MH  - Adiponectin/*blood/*genetics
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - Polymorphism, Restriction Fragment Length
MH  - *Polymorphism, Single Nucleotide
MH  - Prediabetic State/*blood/epidemiology/*genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - adipose tissue
OT  - diabetes mellitus type 2
OT  - obesity
OT  - polymorphism
OT  - rs17300539
EDAT- 2019/09/14 06:00
MHDA- 2019/10/18 06:00
CRDT- 2019/09/14 06:00
PHST- 2019/09/14 06:00 [entrez]
PHST- 2019/09/14 06:00 [pubmed]
PHST- 2019/10/18 06:00 [medline]
AID - /j/enr.2018.52.issue-4/enr-2018-0022/enr-2018-0022.xml [pii]
AID - 10.2478/enr-2018-0022 [doi]
PST - ppublish
SO  - Endocr Regul. 2018 Oct 1;52(4):176-184. doi: 10.2478/enr-2018-0022.