PMID- 31517619
OWN - NLM
STAT- MEDLINE
DCOM- 20200212
LR  - 20200212
IS  - 1336-0329 (Electronic)
IS  - 1210-0668 (Linking)
VI  - 53
IP  - 1
DP  - 2019 Jan 1
TI  - Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in 
      a Brazilian sample of patients with the risk for cardiovascular disease.
PG  - 1-7
LID - /j/enr.2019.53.issue-1/enr-2019-0001/enr-2019-0001.xml [pii]
LID - 10.2478/enr-2019-0001 [doi]
AB  - OBJECTIVE: Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene 
      have been described as the most noteworthy ones regarding the type 2 diabetes 
      mellitus (T2DM) liability. This work is aimed to evaluate the association between 
      rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular 
      disease (CAD) risk. METHODS: A sample of six hundred and forty-seven patients 
      that underwent the coronary angiography in a Cardiac Catheterization Lab was 
      evaluated. The patients were investigated for the presence of T2DM and coronary 
      stenosis. The TCF7L2 polymorphisms were genotyped by real-time PCR and the 
      haplotype analysis was performed with the MLOCUS software. All genetic tests were 
      carried out by considering the haplotype combinations in patients divided into 
      three groups: 0 - carrying none disease risk allele, 1 - carrying one or two risk 
      alleles and 2 - carrying three or four risk alleles. RESULTS: No significant 
      associations between TCF7L2 risk haplotypes and the presence of T2DM or CAD were 
      detected. CONCLUSIONS: Our results indicate that the TCF7L2 rs12255372 and 
      rs7903146 polymorphisms do not influence T2DM in Brazilian patients with the high 
      risk for CAD. Therefore, we assume that these variants may only be relevant for a 
      specific subgroup of T2DM patients or some particular human population.
FAU - Wunsch, Camile
AU  - Wunsch C
AD  - PostgraduateProgram in Biotechnology, Universidade do Vale do Taquari- 
      Univates,Lajeado, RS, Brasil.
FAU - Dornelles, Thais Fernanda
AU  - Dornelles TF
AD  - PostgraduateProgram in Biotechnology, Universidade do Vale do Taquari- 
      Univates,Lajeado, RS, Brasil.
FAU - Girardi, Pricila
AU  - Girardi P
AD  - PostgraduateProgram in Biotechnology, Universidade do Vale do Taquari- 
      Univates,Lajeado, RS, Brasil.
FAU - Arndt, Marcelo Emilio
AU  - Arndt ME
AD  - Hemodynamic Center, Hospital Bruno Born, Lajeado, RS, Brasil.
FAU - Genro, Julia Pasqualini
AU  - Genro JP
AD  - PostgraduateProgram in Biotechnology, Universidade do Vale do Taquari- 
      Univates,Lajeado, RS, Brasil.
AD  - PostgraduateProgram in Biosciences, Universidade Federal de Ciencias da Saude de 
      Porto Alegre, Porto Alegre, RS, Brasil.
FAU - Contini, Veronica
AU  - Contini V
AD  - PostgraduateProgram in Biotechnology, Universidade do Vale do Taquari- 
      Univates,Lajeado, RS, Brasil.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Endocr Regul
JT  - Endocrine regulations
JID - 9112018
RN  - 0 (TCF7L2 protein, human)
RN  - 0 (Transcription Factor 7-Like 2 Protein)
SB  - IM
MH  - Aged
MH  - Brazil/epidemiology
MH  - Cardiovascular Diseases/complications/epidemiology/*genetics
MH  - Case-Control Studies
MH  - Coronary Artery Disease/epidemiology/genetics
MH  - Diabetes Mellitus, Type 2/complications/epidemiology/*genetics
MH  - Diabetic Angiopathies/epidemiology/genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Transcription Factor 7-Like 2 Protein/*genetics
OTO - NOTNLM
OT  - CAD
OT  - T2DM
OT  - association study
OT  - coronary artery disease
OT  - risk score
EDAT- 2019/09/14 06:00
MHDA- 2020/02/13 06:00
CRDT- 2019/09/14 06:00
PHST- 2019/09/14 06:00 [entrez]
PHST- 2019/09/14 06:00 [pubmed]
PHST- 2020/02/13 06:00 [medline]
AID - /j/enr.2019.53.issue-1/enr-2019-0001/enr-2019-0001.xml [pii]
AID - 10.2478/enr-2019-0001 [doi]
PST - ppublish
SO  - Endocr Regul. 2019 Jan 1;53(1):1-7. doi: 10.2478/enr-2019-0001.