PMID- 31518336
OWN - NLM
STAT- MEDLINE
DCOM- 20200902
LR  - 20201003
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 11
IP  - 17
DP  - 2019 Sep 13
TI  - A cohort study of antihyperglycemic medication exposure and survival in patients 
      with gastric cancer.
PG  - 7197-7205
LID - 10.18632/aging.102245 [doi]
AB  - OBJECTIVE: We aimed to estimate survival in gastric cancer patients with type 2 
      diabetes mellitus (T2DM) using different antihyperglycemic medication. METHODS: 
      Patients with gastric cancer and diabetes between 2003-2013 were identified form 
      The Lithuanian Cancer Registry and The National Health Insurance Fund database. 
      Cohort members were classified into five groups: four groups of T2DM patients 
      according to treatment: metformin users; metformin and other medication users; 
      sulphonylurea users; insulin and other medication users; and non-diabetic group. 
      Kaplan-Meier survival analysis and Cox proportional hazards models were used to 
      estimate gastric cancer-specific survival and overall survival. RESULTS: 8423 
      patients met eligibility criteria. Survival analysis showed no differences in 
      gastric cancer-specific survival between non-diabetic and diabetic patient 
      groups. Better survival was observed in the groups of patients using 
      antihyperglycemic medication combinations with metformin, metformin alone or 
      insulin. Lowest survival was observed in diabetic patients who were sulphonylurea 
      users. Survival analysis comparing overall survival between non-diabetic and 
      diabetic patients (p = 0.89) showed no evidence of survival difference between 
      groups and survival differences between antihyperglycemic medication user groups 
      were of borderline significance (p = 0.052). CONCLUSIONS: Antihyperglycemic 
      medication use was not associated with a significant effect on survival in 
      patients with gastric cancer and T2DM.
FAU - Dulskas, Audrius
AU  - Dulskas A
AD  - Department of Abdominal and General Surgery and Oncology, National Cancer 
      Institute, Vilnius LT-08406, Lithuania.
AD  - University of Applied Sciences, Faculty of Health Care, Vilnius ELT-08303, 
      Lithuania.
AD  - Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius 
      LT-03101, Lithuania.
FAU - Patasius, Ausvydas
AU  - Patasius A
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, Vilnius LT-08406, 
      Lithuania.
AD  - Institute of Health Sciences, Faculty of Medicine, Vilnius University, Vilnius 
      LT-03101, Lithuania.
FAU - Linkeviciute-Ulinskiene, Donata
AU  - Linkeviciute-Ulinskiene D
AD  - Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, 
      Vilnius LT-03101, Lithuania.
FAU - Zabuliene, Lina
AU  - Zabuliene L
AD  - Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius 
      LT-03101, Lithuania.
FAU - Smailyte, Giedre
AU  - Smailyte G
AD  - Laboratory of Cancer Epidemiology, National Cancer Institute, Vilnius LT-08406, 
      Lithuania.
AD  - Institute of Health Sciences, Faculty of Medicine, Vilnius University, Vilnius 
      LT-03101, Lithuania.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190913
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Humans
MH  - Hypoglycemic Agents/*therapeutic use
MH  - Lithuania/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Stomach Neoplasms/complications/*mortality
PMC - PMC6756873
OTO - NOTNLM
OT  - antihyperglycemic
OT  - diabetes
OT  - gastric cancer
OT  - metformin
OT  - population-based study
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2019/09/14 06:00
MHDA- 2020/09/04 06:00
PMCR- 2019/09/15
CRDT- 2019/09/14 06:00
PHST- 2019/07/12 00:00 [received]
PHST- 2019/08/22 00:00 [accepted]
PHST- 2019/09/14 06:00 [pubmed]
PHST- 2020/09/04 06:00 [medline]
PHST- 2019/09/14 06:00 [entrez]
PHST- 2019/09/15 00:00 [pmc-release]
AID - 102245 [pii]
AID - 10.18632/aging.102245 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2019 Sep 13;11(17):7197-7205. doi: 10.18632/aging.102245. Epub 
      2019 Sep 13.