PMID- 31520297
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20191203
LR  - 20210110
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 186
IP  - 10
DP  - 2019 Sep 13
TI  - Nanoparticle-based surface assisted laser desorption ionization mass 
      spectrometry: a review.
PG  - 682
LID - 10.1007/s00604-019-3770-5 [doi]
AB  - Great endeavors are undertaken to find effective nanoparticles to replace organic 
      matrices for the analysis of small molecules using laser desorption ionization 
      mass spectrometry (LDI-MS). Nanoparticles offer high sensitivity and better 
      selectivity compared to conventional organic matrices. Surface assisted LDI-MS 
      (SALDI-MS), and surface enhanced LDI-MS (SELDI-MS) provide clear background 
      spectra without observable interferences peaks, and cause no fragmentation (soft 
      ionization) of thermal and acidity labile molecules. This review article (with 
      460 references) summarizes the recent applications of nanoparticles including 
      metallic, metal oxides, silicon, quantum dots, metal-organic frameworks and 
      covalent organic frameworks, for the analysis of small molecules. Nanoparticles 
      serve not only as surface for LDI-MS, but they can be also used as probe or 
      pseudo-stationary phase for separation, enrichment, and microextraction. 
      Hopefully, the knowledge and learning points gained from this review will deepen 
      the understanding of nanoparticles applications for LDI-MS. Graphical Abstract 
      Schematic representation of laser desorption ionization mass spectrometry using 
      various nanoparticles (such as metallic nanoparticles, carbon nanomaterials, 
      silicon based nanomaterials, metal oxides, quantum dots, metal-organic 
      frameworks, and covalent organic frameworks). Advanced technologies using 
      nanoparticles are also reviewed.
FAU - Abdelhamid, Hani Nasser
AU  - Abdelhamid HN
AUID- ORCID: 0000-0002-3106-8302
AD  - Advanced Multifunctional Materials Laboratory, Department of Chemistry, Assiut 
      University, Assiut, 71515, Egypt. hany.abdelhameed@science.au.edu.eg.
LA  - eng
PT  - Journal Article
DEP - 20190913
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
SB  - IM
OTO - NOTNLM
OT  - MOF
OT  - Matrix assisted laser desorption ionization mass spectrometry
OT  - Metal-organic frameworks
OT  - Nanoparticles
OT  - SALDI-MS
OT  - SELDI-MS
OT  - Small molecules
EDAT- 2019/09/15 06:00
MHDA- 2019/09/15 06:01
CRDT- 2019/09/15 06:00
PHST- 2019/03/09 00:00 [received]
PHST- 2019/08/16 00:00 [accepted]
PHST- 2019/09/15 06:00 [entrez]
PHST- 2019/09/15 06:00 [pubmed]
PHST- 2019/09/15 06:01 [medline]
AID - 10.1007/s00604-019-3770-5 [pii]
AID - 10.1007/s00604-019-3770-5 [doi]
PST - epublish
SO  - Mikrochim Acta. 2019 Sep 13;186(10):682. doi: 10.1007/s00604-019-3770-5.