PMID- 31520991
OWN - NLM
STAT- MEDLINE
DCOM- 20200317
LR  - 20200317
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 76
DP  - 2019 Nov
TI  - Modulation of anti-malaria immunity by vitamin A in C57BL/6J mice infected with 
      heterogenic plasmodium.
PG  - 105882
LID - S1567-5769(19)31310-4 [pii]
LID - 10.1016/j.intimp.2019.105882 [doi]
AB  - Vitamin A (VA) is an anti-inflammatory agent that is important in modulating and 
      balancing the immune system. The present study aimed to investigate the 
      immunoregulatory effects of vitamin A supplement (VAS) in C57BL/6J mice infected 
      with Plasmodium yoelii 17XL (P.y17XL) or Plasmodium berghei ANKA (P.bANKA). 
      Following VA treatment, parasitaemia decreased, but survival rate did not 
      significantly change during P.y17XL infection. However, in P.bANKA infected 
      C57BL/6J mice, VA pretreatment decreased parasitaemia, and a lag in cerebral 
      malaria (CM) was observed during the early stages of infection. Furthermore, VA 
      pretreatment was also demonstrated to upregulate MHCII expression in dendritic 
      cells (DCs), downregulate Th1 and Tregs, and downregulate TNF-alpha and IFN-gamma 
      production. The results of the current study indicated that VAS downregulated the 
      inflammation response in CM, but did not exhibit an immunoregulatory effect 
      against P.y17XL infection. VAS protected the onset of CM by reducing 
      inflammation, and was also correlated with the downregulation of Th1 by modifying 
      the function of DCs and Tregs. However, no significant effect was observed during 
      P.y17XL infection.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Chen, Guang
AU  - Chen G
AD  - Department of Basic Medical Sciences, Taizhou University Hospital, Taizhou 
      University, No 1139 Shifu Road, Jiaojiang District, Taizhou 318000, China; 
      Department of Immunology, College of Basic Medical Sciences, China Medical 
      University, Shenyang 110013, China.
FAU - Du, Yun-Ting
AU  - Du YT
AD  - Department of Immunology, College of Basic Medical Sciences, China Medical 
      University, Shenyang 110013, China; Department of Clinical Lab, Cancer Hospital 
      of China Medical University, Liaoning Cancer Hospital & Institute, Number 44 
      Xiaoheyan Road, Dadong District, Shenyang 110042, China.
FAU - Liu, Jian-Hua
AU  - Liu JH
AD  - Department of Laboratory Medicine, Shengjing Hospital of China Medical 
      University, Shenyang 110004, China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Laboratory Medicine, Shengjing Hospital of China Medical 
      University, Shenyang 110004, China.
FAU - Zheng, Li
AU  - Zheng L
AD  - Department of Immunology, College of Basic Medical Sciences, China Medical 
      University, Shenyang 110013, China.
FAU - Qin, Xiao-Song
AU  - Qin XS
AD  - Department of Laboratory Medicine, Shengjing Hospital of China Medical 
      University, Shenyang 110004, China.
FAU - Cao, Ya-Ming
AU  - Cao YM
AD  - Department of Immunology, College of Basic Medical Sciences, China Medical 
      University, Shenyang 110013, China. Electronic address: ymcao@mail.cmu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20190911
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (IFNG protein, mouse)
RN  - 0 (Immunologic Factors)
RN  - 0 (Tnf protein, mouse)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 11103-57-4 (Vitamin A)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/drug effects/immunology
MH  - Female
MH  - Immunologic Factors/*pharmacology
MH  - Interferon-gamma/immunology
MH  - Malaria/*immunology
MH  - Mice, Inbred C57BL
MH  - Parasitemia/*immunology
MH  - *Plasmodium berghei
MH  - *Plasmodium yoelii
MH  - T-Lymphocytes, Regulatory/drug effects/immunology
MH  - Th1 Cells/drug effects/immunology
MH  - Tumor Necrosis Factor-alpha/immunology
MH  - Vitamin A/*pharmacology
OTO - NOTNLM
OT  - Heterogenic plasmodium
OT  - Plasmodium berghei ANKA
OT  - Plasmodium yoelii 17XL
OT  - Protection
OT  - Vitamin A
EDAT- 2019/09/15 06:00
MHDA- 2020/03/18 06:00
CRDT- 2019/09/15 06:00
PHST- 2019/06/18 00:00 [received]
PHST- 2019/09/02 00:00 [revised]
PHST- 2019/09/04 00:00 [accepted]
PHST- 2019/09/15 06:00 [pubmed]
PHST- 2020/03/18 06:00 [medline]
PHST- 2019/09/15 06:00 [entrez]
AID - S1567-5769(19)31310-4 [pii]
AID - 10.1016/j.intimp.2019.105882 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2019 Nov;76:105882. doi: 10.1016/j.intimp.2019.105882. Epub 
      2019 Sep 11.