PMID- 31521580
OWN - NLM
STAT- MEDLINE
DCOM- 20200608
LR  - 20200608
IS  - 2095-4964 (Print)
VI  - 17
IP  - 6
DP  - 2019 Nov
TI  - Therapeutic potential of ethyl acetate fraction of Tephrosia purpurea Linn. 
      leaves in a rat model of gout.
PG  - 455-460
LID - S2095-4964(19)30093-7 [pii]
LID - 10.1016/j.joim.2019.08.002 [doi]
AB  - OBJECTIVE: The present study is to determine the potential treatment effects of 
      ethyl acetate fraction of Tephrosia purpurea Linn. leaves (EATP) against gout. 
      METHODS: Gout in experimental rats was induced with potassium oxonate at the dose 
      of 250 mg/kg (intraperitoneal injection) for 7 consecutive days; EATP was 
      administered 1 h after administration of the potassium oxonate on each day of 
      experiment. Potassium oxonate was discontinued on the 8th day; thereafter 
      allopurinol (10 mg/kg, p.o.) and EATP (200 and 400 mg/kg, p.o.) were continued 
      until day 14. The uric acid level was measured from serum and urine during the 
      experiment. Other biochemical parameters were assessed, including blood and urine 
      creatinine, erythrocyte sedimentation rate, and total protein. Blood urea 
      nitrogen, serum aspartate aminotransferase serum alanine aminotransferase and 
      alkaline phosphatase were also measured. The blood was analyzed for levels of 
      malondialdehyde and the antioxidant enzymes such as superoxide dismutase, 
      catalase and glutathione peroxidase. Histopathological and radiological changes 
      in the ankle of rats were observed after completion of the experiment. RESULTS: 
      EATP was able to decrease serum uric acid and creatinine level; it also reduced 
      inflammation, oxidative stress and lysosomal enzyme level, which has a role in 
      acute inflammation. EATP increased uric acid excretion through urine due to its 
      uricosuric effect. CONCLUSION: EATP lowered the serum uric acid level and 
      increased the urine uric acid level through excretion, which is useful in the 
      treatment of gout. Hence the EATP was found to be helpful in the treatment of 
      gout.
CI  - Copyright (c) 2019 Shanghai Changhai Hospital. Published by Elsevier B.V. All 
      rights reserved.
FAU - Nipate, Sonali S
AU  - Nipate SS
AD  - Department of Pharmacology, Progressive Education Society's Modern College of 
      Pharmacy, Yamunanagar, Nigdi, Pune 411044, Maharashtra, India. Electronic 
      address: sonynipate@rediffmail.com.
FAU - Yelmar, Pramila S
AU  - Yelmar PS
AD  - Department of Pharmacology, Progressive Education Society's Modern College of 
      Pharmacy, Yamunanagar, Nigdi, Pune 411044, Maharashtra, India.
LA  - eng
PT  - Journal Article
DEP - 20190822
PL  - Netherlands
TA  - J Integr Med
JT  - Journal of integrative medicine
JID - 101603118
RN  - 0 (Acetates)
RN  - 0 (Plant Extracts)
RN  - 268B43MJ25 (Uric Acid)
RN  - 76845O8NMZ (ethyl acetate)
SB  - IM
MH  - Acetates
MH  - Animals
MH  - Disease Models, Animal
MH  - Gout/*drug therapy
MH  - Male
MH  - Plant Extracts/*pharmacology
MH  - Plant Leaves/chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tephrosia/*chemistry
MH  - Uric Acid/*blood/*urine
OTO - NOTNLM
OT  - Allopurinol
OT  - Ethyl acetate fraction
OT  - Gout
OT  - Potassium oxonate
OT  - Radiological evaluation
OT  - Tephrosia purpurea Linn. leaves
OT  - Uric acid deposition
EDAT- 2019/09/16 06:00
MHDA- 2020/06/09 06:00
CRDT- 2019/09/16 06:00
PHST- 2018/10/29 00:00 [received]
PHST- 2019/03/18 00:00 [accepted]
PHST- 2019/09/16 06:00 [pubmed]
PHST- 2020/06/09 06:00 [medline]
PHST- 2019/09/16 06:00 [entrez]
AID - S2095-4964(19)30093-7 [pii]
AID - 10.1016/j.joim.2019.08.002 [doi]
PST - ppublish
SO  - J Integr Med. 2019 Nov;17(6):455-460. doi: 10.1016/j.joim.2019.08.002. Epub 2019 
      Aug 22.