PMID- 31522432
OWN - NLM
STAT- MEDLINE
DCOM- 20200211
LR  - 20201019
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 18
IP  - 3
DP  - 2019 Jun 8
TI  - Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update 
      Meta-analysis.
PG  - 251-261
LID - 10.18502/ijaai.v18i3.1118 [doi]
AB  - Growing evidence indicated conflicting results that Interleukin-18 (IL-18) 
      promoter polymorphisms rs1946518 (A-607C), rs187238 (G-137C) and rs549908 
      (A-105C) were associated with asthma risk. The aim of this study is to 
      comprehensively evaluate the IL-18 polymorphisms and asthma by a systematic 
      review and meta-analysis. A total of 12 studies testing the association between 
      these polymorphisms and asthma were examined (8 studies for A-607C, 8 studies for 
      G-137C, and 4 studies for A-105C) in the update meta-analysis, up to Dec 30, 
      2017. Summary odds ratios (ORs) and 95% confidence intervals (CI) were used to 
      estimate the strength of association between each polymorphism and asthma using 
      fixed- and random-effects models when appropriate. Heterogeneity and publication 
      bias were evaluated. The meta-analysis results indicated that any allele 
      frequencies of the IL-18 polymorphisms (A-607C, G-137C and A-105C) was not 
      associated with asthma risk (p>0.05). And no statistically significant 
      association was observed between genotype frequencies of these polymorphisms and 
      asthma under different genetic models (p>0.05). Subgroup analysis results were 
      similar to the main analysis by ethnicity, sample size, genotyping methods, 
      matching criteria and quality score. There was no evidence of publication bias. 
      The present meta-analysis suggests that IL-18 polymorphisms (A-607C, G-137C and 
      A-105C) were unlikely to be associated with asthma risk.
FAU - Liu, Huan
AU  - Liu H
AD  - Department of Preventive Medicine, North Sichuan Medical College, Nanchong, 
      Sichuan, China AND Department of Forensic Medicine, North Sichuan Medical 
      College, Nanchong, Sichuan, China. 244933432@qq.com.
FAU - Feng, Yu
AU  - Feng Y
AD  - Department of Criminal Science and Technology, Chongqing Police College, 
      Chongqing, China. xyun2005@163.com.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Forensic Medicine, North Sichuan Medical College, Nanchong, 
      Sichuan, China. 896514886@qq.com.
FAU - Deng, Xiao-Dong
AU  - Deng XD
AD  - Department of Forensic Medicine, North Sichuan Medical College, Nanchong, 
      Sichuan, China. 857123409@qq.com.
FAU - Ma, Ying
AU  - Ma Y
AD  - Department of Neurology, Affiliated Hospital of North Sichuan Medical College, 
      Nanchong, Sichuan, China. yingma1314@126.com.
FAU - Liu, Yun
AU  - Liu Y
AD  - Department of Forensic Medicine, North Sichuan Medical College, Nanchong, 
      Sichuan, China. xyun2005@163.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20190608
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Alleles
MH  - Asthma/*genetics
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Heterogeneity
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Publication Bias
MH  - Risk Assessment
MH  - Risk Factors
OTO - NOTNLM
OT  - Asthma
OT  - Genetic susceptibility
OT  - Interleukin-18
OT  - Meta-analysis
OT  - Single nucleotide polymorphism
EDAT- 2019/09/16 06:00
MHDA- 2020/02/12 06:00
CRDT- 2019/09/16 06:00
PHST- 2018/04/05 00:00 [received]
PHST- 2019/01/12 00:00 [accepted]
PHST- 2019/09/16 06:00 [entrez]
PHST- 2019/09/16 06:00 [pubmed]
PHST- 2020/02/12 06:00 [medline]
AID - 10.18502/ijaai.v18i3.1118 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2019 Jun 8;18(3):251-261. doi: 
      10.18502/ijaai.v18i3.1118.