PMID- 31522447
OWN - NLM
STAT- MEDLINE
DCOM- 20200205
LR  - 20200205
IS  - 1735-5249 (Electronic)
IS  - 1735-1502 (Linking)
VI  - 18
IP  - 4
DP  - 2019 Aug 17
TI  - Genetic Polymorphisms of CXCL8 (-251) Are Associated with the Susceptibility of 
      Helicobacter pylori Infection Increased the Risk of Inflammation and Gastric 
      Cancer in Thai Gastroduodenal Patients.
PG  - 393-401
LID - 10.18502/ijaai.v18i4.1417 [doi]
AB  - CXC Chemokine Ligand 8 (CXCL8) plays an important role in gastric inflammation 
      and in the progression of gastric cancer induced by Helicobacter pylori (H. 
      pylori) infection. The association of CXCL8, CXC Chemokine Receptor 1 (CXCR1), 
      and CXC Chemokine Receptor 2 (CXCR2) polymorphisms with H. pylori infection and 
      gastric cancer progression needs to be investigated in a population within an 
      enigma area consisting of multiple ethnicities, such as Thailand. To analyze the 
      relative risk of H. pylori infection and gastric cancer among Thai gastroduodenal 
      patients, gene polymorphisms in CXCL8 (promoter region -251) and in CXCR1 and 
      CXCR2 (receptors for CXCL8) were detected by polymerase chain 
      reaction-restriction fragment length polymorphism (PCR-RFLP) and allele 
      specific-PCR (AS-PCR). We also determined the presence of cytotoxin-associated 
      gene A (cagA) in Thai patients with H. pylori infection. Correlation between the 
      CXCL8 (-251) polymorphism and CXCL8 gene expression was evaluated by quantitative 
      reverse transcriptase-PCR (qRT-PCR). We found a significant association between 
      the T/A and A/A genotypes of CXCL8 (-251) with H. pylori infection. However, no 
      significant correlation was found between the CXCR1 (+2607) and CXCR2 (+1208) 
      gene polymorphisms with H. pylori infection among Thai gastroduodenal subjects. 
      Within the H. pylori-infected group of Thai gastroduodenal patients, no 
      significant differences in cagA were observed. In addition, the A/A genotype of 
      CXCL8 (-251) significantly correlated with the risk of gastric cancer and 
      correlated with higher CXCL8 gene expression levels in Thai gastroduodenal 
      patients. These results suggest that CXCL8 (-251) polymorphisms are associated 
      with H. pylori infection, an increased risk of stronger inflammatory responses, 
      and gastric cancer in Thai gastroduodenal patients.
FAU - Boonyanugomol, Wongwarut
AU  - Boonyanugomol W
AD  - Department of Sciences and Liberal Arts, Mahidol University, Amnat Charoen 
      Campus, Amnat Charoen, Thailand. wongwarut.boo@mahidol.ac.th.
FAU - Rukseree, Kamolchanok
AU  - Rukseree K
AD  - Department of Sciences and Liberal Arts, Mahidol University, Amnat Charoen 
      Campus, Amnat Charoen, Thailand. Kamolchanok.ruk@mahidol.edu.
FAU - Kongkasame, Worrarat
AU  - Kongkasame W
AD  - Unit of Endoscopy Medicine, Suppasittiprasong Hospital, Ubon Ratchathani, 
      Thailand. Worrarat-eab@hotmail.com.
FAU - Palittapongarnpim, Prasit
AU  - Palittapongarnpim P
AD  - Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, 
      Thailand. Prasit.pal@mahidol.ac.th.
FAU - Baik, Seung-Chul
AU  - Baik SC
AD  - Department of Microbiology, Gyeongsang National Institute of Health Sciences, 
      School of Medicine, Gyeongsang National University, Jinju, Republic of Korea. 
      scbaik@gnu.ac.kr.
FAU - Manwong, Mereerat
AU  - Manwong M
AD  - College of Medicine and Public Health, Ubon Ratchathani University, Ubon 
      Ratchathani, Thailand. Mereerat_s@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190817
PL  - Iran
TA  - Iran J Allergy Asthma Immunol
JT  - Iranian journal of allergy, asthma, and immunology
JID - 101146178
RN  - 0 (Interleukin-8)
SB  - IM
MH  - Alleles
MH  - Disease Susceptibility
MH  - Female
MH  - Gastritis/complications/epidemiology/*etiology
MH  - Gene Frequency
MH  - Genotype
MH  - Helicobacter Infections/*complications/microbiology
MH  - *Helicobacter pylori
MH  - Humans
MH  - Interleukin-8/*genetics
MH  - Male
MH  - *Polymorphism, Genetic
MH  - Population Surveillance
MH  - Stomach Neoplasms/epidemiology/*etiology
MH  - Thailand/epidemiology
OTO - NOTNLM
OT  - CXC chemokine ligand 8
OT  - CXC chemokine receptor 1
OT  - CXC chemokine receptor 2
OT  - Gene polymorphism
OT  - Helicobacter pylori
OT  - Thai
EDAT- 2019/09/16 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/09/16 06:00
PHST- 2018/12/09 00:00 [received]
PHST- 2019/04/16 00:00 [accepted]
PHST- 2019/09/16 06:00 [entrez]
PHST- 2019/09/16 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
AID - 10.18502/ijaai.v18i4.1417 [doi]
PST - epublish
SO  - Iran J Allergy Asthma Immunol. 2019 Aug 17;18(4):393-401. doi: 
      10.18502/ijaai.v18i4.1417.