PMID- 31523150
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231013
IS  - 1300-0667 (Print)
IS  - 1309-4866 (Electronic)
IS  - 1300-0667 (Linking)
VI  - 56
IP  - 3
DP  - 2019 Sep
TI  - Comparison of Clinical Characteristics Between the Patients with Schizophrenia on 
      Clozapine Treatment with Those Taking Combination of Long-Acting Injectable and 
      Oral Antipsychotics.
PG  - 219-223
LID - 10.29399/npa.23548 [doi]
AB  - INTRODUCTION: The primary aim of this study was to compare clinical 
      characteristics between the patients with schizophrenia on clozapine treatment 
      with those under combination of long-acting injectable and oral antipsychotics 
      (combined treatment), and the secondary aim was to evaluate the impact of 
      obsessive-compulsive disorder (OCD) comorbidity on the clinical variables. 
      METHODS: The patients with schizophrenia applied at Outpatient Psychiatry Clinic 
      of the University between October 2017 and March 2018 taking clozapine or 
      combined treatment were included in the study. The participants were administered 
      Brief Psychiatric Rating Scale (BPRS), Clinical Global Impressions Scale, Scale 
      for the Assessment of Positive and Negative Symptoms (SAPS/SANS), Calgary 
      Depression Scale for Schizophrenia (CDSS), Yale-Brown Obsessive Compulsive Scale 
      (YBOCS), Turkish version of Schedule for Assessing the three components of 
      insight (SAI), and Global Assessment of Functioning Scale (GAF). RESULTS: 
      Patients on clozapine had higher Y-BOCS, BPRS, SANS, CDSS scores, and lower GAF 
      scores compared to those taking combined antipsychotics (p<0.05). OCD comorbidity 
      rate was 13% in the combination therapy group and 36% in clozapine users. The 
      SAPS scores were higher but CDSS scores were lower in clozapine users with the 
      presence of OCD comorbidity (p<0.05). CONCLUSION: Clozapine and combined therapy 
      groups differed widely by the clinical characteristics of the patients in this 
      study. Both groups showed a high OCD comorbidity rate in this study and OCD 
      comorbidity should be considered when schizophrenia treatment is initiated to 
      obtain more satisfactory results. Furthermore, patients on clozapine seem to show 
      a different relationship with OCD comorbidity compared to those under combined 
      treatment.
FAU - Kokurcan, Ahmet
AU  - Kokurcan A
AD  - Health Sciences University, Diskapi Yildirim Beyazit Research and Training 
      Hospital, Psychiatry Clinic, Ankara, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190716
PL  - Turkey
TA  - Noro Psikiyatr Ars
JT  - Noro psikiyatri arsivi
JID - 9426194
PMC - PMC6732814
OTO - NOTNLM
OT  - Schizophrenia
OT  - antipsychotic
OT  - polypharmacy
COIS- Conflict of Interest: There are no conflicts of interest in the study.
EDAT- 2019/09/17 06:00
MHDA- 2019/09/17 06:01
PMCR- 2019/07/16
CRDT- 2019/09/17 06:00
PHST- 2018/12/20 00:00 [received]
PHST- 2019/03/12 00:00 [accepted]
PHST- 2019/09/17 06:00 [entrez]
PHST- 2019/09/17 06:00 [pubmed]
PHST- 2019/09/17 06:01 [medline]
PHST- 2019/07/16 00:00 [pmc-release]
AID - archneuro-56-219 [pii]
AID - 10.29399/npa.23548 [doi]
PST - epublish
SO  - Noro Psikiyatr Ars. 2019 Jul 16;56(3):219-223. doi: 10.29399/npa.23548. 
      eCollection 2019 Sep.