PMID- 31524071
OWN - NLM
STAT- MEDLINE
DCOM- 20210604
LR  - 20210604
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Linking)
VI  - 30
IP  - 6
DP  - 2020 Jun
TI  - Risk for Thyroid Cancer Recurrence Is Higher in Men Than in Women Independent of 
      Disease Stage at Presentation.
PG  - 871-877
LID - 10.1089/thy.2018.0775 [doi]
AB  - Background: Well-differentiated thyroid cancer (DTC) presents at a more advanced 
      stage in men than in women, and the mortality in men is higher than that in 
      women. However, it is not clear whether DTC recurrence is affected by sex 
      independent of stage at presentation. The objective of the present study was to 
      assess if male sex is an independent risk factor for recurrence of DTC. Methods: 
      The Canadian Collaborative Network for Cancer of the Thyroid (CANNECT) is a 
      collaborative registry to describe patterns of care for thyroid cancer. We 
      included patients from the CANNECT registry with DTC diagnosed at age 18 or older 
      between 2000 and 2010. We compared men and women with respect to presentation, 
      management, and recurrence risk, stratified for American Joint Committee on 
      Cancer (AJCC) stage. Results: We included 2595 patients, 2067 (79.7%) women and 
      528 (20.3%) men. Men presented with more advanced AJCC stage (p < 0.001), T stage 
      (p < 0.001), N stage (p < 0.001), and M stage (p = 0.002) There was no difference 
      in follow-up duration between women (7.7 +/- 4.0 [mean +/- standard deviation] years) 
      and men (7.7 +/- 4.0 years, p = 0.985). Overall recurrence was 2.2% (n = 46) for 
      women and 8.5% (n = 45) for men (p < 0.001). In multivariate analysis adjusted 
      for AJCC stage, men were at significantly greater risk for DTC recurrence than 
      women (adjusted hazard ratio 2.72 [95% confidence interval [CI] 1.78-4.20]; 
      p < 0.001). In multivariate analysis adjusted for tumor-node-metastasis (TNM) 
      stage, men were at significantly greater risk for DTC recurrence than women 
      (adjusted hazard ratio 2.31 [CI 1.48-3.60]; p < 0.001). Conclusions: Our study 
      confirms that the risk for recurrence of DTC is higher in men than in women. 
      Although men tend to present with more advanced-stage disease, the difference in 
      recurrence risk persists when adjusted for stage of presentation. It needs to be 
      determined whether sex should influence follow-up intensity and/or duration.
FAU - Zahedi, Afshan
AU  - Zahedi A
AD  - Department of Medicine, Women's College Hospital, Toronto, Canada.
FAU - Bondaz, Louis
AU  - Bondaz L
AD  - Hopital Maisonneuve-Rosemont, Universite de Montreal, Montreal, Canada.
FAU - Rajaraman, Murali
AU  - Rajaraman M
AD  - Department of Radiation Oncology, Dalhousie University, Halifax, Canada.
FAU - Leslie, William D
AU  - Leslie WD
AD  - Department of Internal Medicine and University of Manitoba, Winnipeg, Canada.
FAU - Jefford, Cheryl
AU  - Jefford C
AD  - Department of Radiology and Memorial University, St. John's, Canada.
AD  - Department of Nuclear Medicine, Memorial University, St. John's, Canada.
FAU - Young, James Edward
AU  - Young JE
AD  - Department of Surgery, McMaster University, Hamilton, Canada.
FAU - Pathak, K Alok
AU  - Pathak KA
AD  - Department of Surgery, University of Manitoba, Winnipeg, Canada.
FAU - Bureau, Yves
AU  - Bureau Y
AD  - Department of Imaging and Western University, London, Ontario, Canada.
FAU - Rachinsky, Irina
AU  - Rachinsky I
AD  - Department of Imaging, Division of Nuclear Medicine, Western University, London, 
      Ontario, Canada.
FAU - Badreddine, M
AU  - Badreddine M
AD  - Department of Imaging, Division of Nuclear Medicine, Western University, London, 
      Ontario, Canada.
FAU - De Brabandere, Sarah
AU  - De Brabandere S
AD  - Department of Imaging, Division of Nuclear Medicine, Western University, London, 
      Ontario, Canada.
FAU - Fong, Helen
AU  - Fong H
AD  - Department of Radiation Oncology, Dalhousie University, Halifax, Canada.
FAU - Maniakas, Anastasios
AU  - Maniakas A
AD  - Department of Surgery, Universite de Montreal, Montreal, Canada.
FAU - Van Uum, Stan
AU  - Van Uum S
AD  - Department of Medicine, Western University, London, Ontario, Canada.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20191113
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
SB  - IM
MH  - Adenocarcinoma, Follicular/*pathology
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Lymphatic Metastasis/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local/*pathology
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Risk Factors
MH  - Sex Factors
MH  - Thyroid Cancer, Papillary/*pathology
MH  - Thyroid Gland/*pathology
MH  - Thyroid Neoplasms/*pathology
OTO - NOTNLM
OT  - follow-up
OT  - recurrence
OT  - risk stratification
OT  - sex
OT  - thyroid cancer
EDAT- 2019/09/17 06:00
MHDA- 2021/06/05 06:00
CRDT- 2019/09/17 06:00
PHST- 2019/09/17 06:00 [pubmed]
PHST- 2021/06/05 06:00 [medline]
PHST- 2019/09/17 06:00 [entrez]
AID - 10.1089/thy.2018.0775 [doi]
PST - ppublish
SO  - Thyroid. 2020 Jun;30(6):871-877. doi: 10.1089/thy.2018.0775. Epub 2019 Nov 13.