PMID- 31525320
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20220110
IS  - 2040-1752 (Electronic)
IS  - 2040-1744 (Linking)
VI  - 11
IP  - 4
DP  - 2020 Aug
TI  - Maternal folic acid supplementation does not counteract the deleterious impact of 
      prenatal exposure to environmental pollutants on lipid homeostasis in male rat 
      descendants.
PG  - 427-437
LID - 10.1017/S2040174419000497 [doi]
AB  - Prenatal exposure to persistent organic pollutants (POPs) has been associated 
      with the development of metabolic syndrome-related diseases in offspring. 
      According to epidemiological studies, father's transmission of environmental 
      effects in addition to mother's can influence offspring health. Moreover, 
      maternal prenatal dietary folic acid (FA) may beneficially impact offspring 
      health. The objective is to investigate whether prenatal FA supplementation can 
      overcome the deleterious effects of prenatal exposure to POPs on lipid 
      homeostasis and inflammation in three generations of male rat descendants through 
      the paternal lineage. Female Sprague-Dawley rats (F0) were exposed to a POPs 
      mixture (or corn oil) +/- FA supplementation for 9 weeks before and during 
      gestation. F1 and F2 males were mated with untreated females. Plasma and hepatic 
      lipids were measured in F1, F2, and F3 males after 12-h fast. Gene expression of 
      inflammatory cytokines was determined by qPCR in epididymal adipose tissue. In F1 
      males, prenatal POPs exposure increased plasma lipids at 14 weeks old and hepatic 
      lipids at 28 weeks old and prenatal FA supplementation decreased plasma total 
      cholesterol at 14 weeks old. Prenatal POPs exposure decreased plasma 
      triglycerides at 14 weeks old in F2 males. No change was observed in inflammatory 
      markers. Our results show an impact of the paternal lineage on lipid homeostasis 
      in rats up to the F2 male generation. FA supplementation of the F0 diet, 
      regardless of POPs exposure, lowered plasma cholesterol in F1 males but failed to 
      attenuate the deleterious effects of prenatal POPs exposure on plasma and hepatic 
      lipids in F1 males.
FAU - Navarro, Pauline
AU  - Navarro P
AD  - School of Nutrition, Faculty of Agricultural and Food Sciences, Centre de 
      recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec City, QC, 
      Canada.
AD  - Department of Animal Sciences, Faculty of Agricultural and Food Sciences, Centre 
      de recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
FAU - Dalvai, Mathieu
AU  - Dalvai M
AD  - Department of Animal Sciences, Faculty of Agricultural and Food Sciences, Centre 
      de recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
FAU - Charest, Phanie L
AU  - Charest PL
AD  - Department of Animal Sciences, Faculty of Agricultural and Food Sciences, Centre 
      de recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
FAU - Herst, Pauline M
AU  - Herst PM
AD  - Department of Animal Sciences, Faculty of Agricultural and Food Sciences, Centre 
      de recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
FAU - Lessard, Maryse
AU  - Lessard M
AD  - Department of Animal Sciences, Faculty of Agricultural and Food Sciences, Centre 
      de recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
FAU - Marcotte, Bruno
AU  - Marcotte B
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec City, QC, 
      Canada.
AD  - Department of Medicine, Faculty of Medicine, Quebec Heart and Lung Institute 
      Cardiology Group, Universite Laval, Quebec City, QC, Canada.
FAU - Mitchell, Patricia L
AU  - Mitchell PL
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec City, QC, 
      Canada.
AD  - Department of Medicine, Faculty of Medicine, Quebec Heart and Lung Institute 
      Cardiology Group, Universite Laval, Quebec City, QC, Canada.
FAU - Leblanc, Nadine
AU  - Leblanc N
AD  - School of Nutrition, Faculty of Agricultural and Food Sciences, Centre de 
      recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec City, QC, 
      Canada.
FAU - Kimmins, Sarah
AU  - Kimmins S
AD  - Department of Animal Science, Faculty of Agricultural and Environmental Sciences, 
      McGill University, Montreal, QC, Canada.
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill 
      University, Montreal, Quebec, Canada.
FAU - Trasler, Jacquetta
AU  - Trasler J
AD  - Departments of Pediatrics, McGill University, Montreal Children's Hospital, 
      McGill University Health Centre Research Institute, Montreal, QC, Canada.
FAU - MacFarlane, Amanda J
AU  - MacFarlane AJ
AD  - Nutrition Research Division, Health Canada, Ottawa, Canada.
FAU - Marette, Andre
AU  - Marette A
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec City, QC, 
      Canada.
AD  - Department of Medicine, Faculty of Medicine, Quebec Heart and Lung Institute 
      Cardiology Group, Universite Laval, Quebec City, QC, Canada.
FAU - Bailey, Janice L
AU  - Bailey JL
AD  - Department of Animal Sciences, Faculty of Agricultural and Food Sciences, Centre 
      de recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
FAU - Jacques, Helene
AU  - Jacques H
AUID- ORCID: 0000-0002-2755-6346
AD  - School of Nutrition, Faculty of Agricultural and Food Sciences, Centre de 
      recherche en reproduction, developpement et sante intergenerationnelle, 
      Universite Laval, Quebec City, QC, Canada.
AD  - Institute of Nutrition and Functional Foods, Universite Laval, Quebec City, QC, 
      Canada.
LA  - eng
GR  - 01433-000/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190916
PL  - England
TA  - J Dev Orig Health Dis
JT  - Journal of developmental origins of health and disease
JID - 101517692
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - *Dietary Supplements
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Folic Acid/*administration & dosage
MH  - Homeostasis
MH  - Inflammation/chemically induced/drug therapy/*pathology
MH  - Lipids/*analysis
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced/drug therapy/*pathology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Pollutant
OT  - folic acid
OT  - lipids
OT  - male lineage
OT  - prenatal exposure
EDAT- 2019/09/17 06:00
MHDA- 2022/01/11 06:00
CRDT- 2019/09/17 06:00
PHST- 2019/09/17 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
PHST- 2019/09/17 06:00 [entrez]
AID - S2040174419000497 [pii]
AID - 10.1017/S2040174419000497 [doi]
PST - ppublish
SO  - J Dev Orig Health Dis. 2020 Aug;11(4):427-437. doi: 10.1017/S2040174419000497. 
      Epub 2019 Sep 16.