PMID- 31526827
OWN - NLM
STAT- MEDLINE
DCOM- 20210308
LR  - 20210308
IS  - 1090-2139 (Electronic)
IS  - 0889-1591 (Linking)
VI  - 83
DP  - 2020 Jan
TI  - Maternal immune activation during pregnancy impacts on brain structure and 
      function in the adult offspring.
PG  - 56-67
LID - S0889-1591(19)30178-3 [pii]
LID - 10.1016/j.bbi.2019.09.011 [doi]
AB  - Gestational infection constitutes a risk factor for the occurrence of psychiatric 
      disorders in the offspring. Activation of the maternal immune system (MIA) with 
      subsequent impact on the development of the fetal brain is considered to form the 
      neurobiological basis for aberrant neural wiring and the psychiatric 
      manifestations later in offspring life. The examination of validated animal 
      models constitutes a premier resource for the investigation of the neural 
      underpinnings. Here we used a mouse model of MIA based upon systemic treatment of 
      pregnant mice with Poly(I:C) (polyriboinosinic-polyribocytidilic acid), for the 
      unbiased and comprehensive analysis of the impact of MIA on adult offspring brain 
      activity, morphometry, connectivity and function by a magnetic resonance imaging 
      (MRI) approach. Overall lower neural activity, smaller brain regions and less 
      effective fiber structure were observed for Poly(I:C) offspring compared to the 
      control group. The corpus callosum was significantly smaller and presented with a 
      disruption in myelin/ fiber structure in the MIA progeny. Subsequent 
      resting-state functional MRI experiments demonstrated a paralleling dysfunctional 
      interhemispheric connectivity. Additionally, while the overall flow of 
      information was intact, cortico-limbic connectivity was hampered and limbic 
      circuits revealed hyperconnectivity in Poly(I:C) offspring. Our study sheds new 
      light on the impact of maternal infection during pregnancy on the offspring brain 
      and identifies aberrant resting-state functional connectivity patterns as 
      possible correlates of the behavioral phenotype with relevance for psychiatric 
      disorders.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Kreitz, Silke
AU  - Kreitz S
AD  - Institute of Experimental and Clinical Pharmacology and Toxicology, 
      Friedrich-Alexander University Erlangen-Nurnberg (FAU), Germany.
FAU - Zambon, Alice
AU  - Zambon A
AD  - Department of Neurophysiology and Neuropharmacology, Medical University of 
      Vienna, Austria.
FAU - Ronovsky, Marianne
AU  - Ronovsky M
AD  - Department of Neurophysiology and Neuropharmacology, Medical University of 
      Vienna, Austria.
FAU - Budinsky, Lubos
AU  - Budinsky L
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of Molecular 
      and Gender Imaging, Medical University of Vienna, Austria.
FAU - Helbich, Thomas H
AU  - Helbich TH
AD  - Department of Biomedical Imaging and Image-Guided Therapy, Division of Molecular 
      and Gender Imaging, Medical University of Vienna, Austria.
FAU - Sideromenos, Spyros
AU  - Sideromenos S
AD  - Department of Neurophysiology and Neuropharmacology, Medical University of 
      Vienna, Austria.
FAU - Ivan, Claudiu
AU  - Ivan C
AD  - Institute of Experimental and Clinical Pharmacology and Toxicology, 
      Friedrich-Alexander University Erlangen-Nurnberg (FAU), Germany.
FAU - Konerth, Laura
AU  - Konerth L
AD  - Institute of Experimental and Clinical Pharmacology and Toxicology, 
      Friedrich-Alexander University Erlangen-Nurnberg (FAU), Germany.
FAU - Wank, Isabel
AU  - Wank I
AD  - Institute of Experimental and Clinical Pharmacology and Toxicology, 
      Friedrich-Alexander University Erlangen-Nurnberg (FAU), Germany.
FAU - Berger, Angelika
AU  - Berger A
AD  - Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 
      Austria.
FAU - Pollak, Arnold
AU  - Pollak A
AD  - Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 
      Austria.
FAU - Hess, Andreas
AU  - Hess A
AD  - Institute of Experimental and Clinical Pharmacology and Toxicology, 
      Friedrich-Alexander University Erlangen-Nurnberg (FAU), Germany. Electronic 
      address: andreas.hess@fau.de.
FAU - Pollak, Daniela D
AU  - Pollak DD
AD  - Department of Neurophysiology and Neuropharmacology, Medical University of 
      Vienna, Austria. Electronic address: daniela.pollak@meduniwien.ac.at.
LA  - eng
GR  - P 27520/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190914
PL  - Netherlands
TA  - Brain Behav Immun
JT  - Brain, behavior, and immunity
JID - 8800478
RN  - O84C90HH2L (Poly I-C)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Brain/diagnostic imaging
MH  - Disease Models, Animal
MH  - Female
MH  - Mental Disorders/*etiology/*immunology
MH  - Mice
MH  - Poly I-C/immunology
MH  - Pregnancy/*immunology
MH  - Prenatal Exposure Delayed Effects/*immunology/*psychology
OTO - NOTNLM
OT  - Animal model
OT  - Corpus callosum
OT  - Cortico-limbic connectivity
OT  - MEMRI
OT  - Poly(I:C)
OT  - fMRI
EDAT- 2019/09/19 06:00
MHDA- 2021/03/09 06:00
CRDT- 2019/09/19 06:00
PHST- 2019/02/18 00:00 [received]
PHST- 2019/09/03 00:00 [revised]
PHST- 2019/09/12 00:00 [accepted]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2021/03/09 06:00 [medline]
PHST- 2019/09/19 06:00 [entrez]
AID - S0889-1591(19)30178-3 [pii]
AID - 10.1016/j.bbi.2019.09.011 [doi]
PST - ppublish
SO  - Brain Behav Immun. 2020 Jan;83:56-67. doi: 10.1016/j.bbi.2019.09.011. Epub 2019 
      Sep 14.