PMID- 31527215
OWN - NLM
STAT- MEDLINE
DCOM- 20200224
LR  - 20210917
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 12
IP  - 9
DP  - 2019 Sep 16
TI  - Autoimmune encephalitis: the clinical evolution as a key to the diagnosis.
LID - 10.1136/bcr-2019-231094 [doi]
LID - e231094
AB  - Anti-N-methyl D-aspartate receptor (NMDAR) encephalitis is a devastating disease, 
      that despite being increasingly diagnosed, there are no consensus guidelines for 
      the optimal management. A previously healthy 3-year-old-boy brought to the 
      emergency department due to seizures. Neurological examination was normal, and 
      electroencephalogram (EEG) suggested focal epilepsy. Anticonvulsive medication 
      was initiated. He progressively lost age-appropriate language skills, presented 
      behavioural changes and psychiatric symptoms. Neurological examination at that 
      time revealed symmetric gross motor weakness of the lower limbs. Brain and spinal 
      cord MRI and cerebrospinal fluid were normal. Repeated EEG showed global 
      lentification. Steroid therapy was initiated for the suspicion of autoimmune 
      encephalitis, later confirmed as NMDAR encephalitis. He became clinically 
      improved after 10 days of treatment but only returned to his baseline after 
      3 months of disease onset. The authors emphasised the variable course of the 
      disease and possible late response to treatment.
CI  - (c) BMJ Publishing Group Limited 2019. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Teixeira, Sara
AU  - Teixeira S
AD  - Pediatrics Department, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila 
      Nova de Gaia, Portugal.
FAU - Caldeira Santos, Joana
AU  - Caldeira Santos J
AD  - Pediatrics Department, Centro Hospitalar de Vila Nova de Gaia Espinho EPE, Vila 
      Nova de Gaia, Portugal.
FAU - Vila Real, Marta
AU  - Vila Real M
AD  - Unit of Neurosciences of Childhood and Adolescence, Pediatric Service, Centro 
      Hospitalar de Vila Nova de Gaia e Espinho, EPE, Vila Nova de Gaia, Portugal.
FAU - Santos, Fatima
AU  - Santos F
AD  - Unit of Neurosciences of Childhood and Adolescence, Pediatric Service, Centro 
      Hospitalar de Vila Nova de Gaia e Espinho, EPE, Vila Nova de Gaia, Portugal.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20190916
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Anticonvulsants)
RN  - 0 (Glucocorticoids)
RN  - 44YRR34555 (Levetiracetam)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Anti-N-Methyl-D-Aspartate Receptor Encephalitis/*drug therapy
MH  - Anticonvulsants/therapeutic use
MH  - Child, Preschool
MH  - Disease Progression
MH  - Glucocorticoids/therapeutic use
MH  - Humans
MH  - Levetiracetam/*therapeutic use
MH  - Male
MH  - Methylprednisolone/*therapeutic use
MH  - Seizures
PMC - PMC6754659
OTO - NOTNLM
OT  - child and adolescent psychiatry (paediatrics)
OT  - epilepsy and seizures
OT  - neurology
OT  - paediatrics
COIS- Competing interests: None declared.
EDAT- 2019/09/19 06:00
MHDA- 2020/02/25 06:00
PMCR- 2021/09/16
CRDT- 2019/09/19 06:00
PHST- 2019/09/19 06:00 [entrez]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/02/25 06:00 [medline]
PHST- 2021/09/16 00:00 [pmc-release]
AID - 12/9/e231094 [pii]
AID - bcr-2019-231094 [pii]
AID - 10.1136/bcr-2019-231094 [doi]
PST - epublish
SO  - BMJ Case Rep. 2019 Sep 16;12(9):e231094. doi: 10.1136/bcr-2019-231094.