PMID- 31527473
OWN - NLM
STAT- MEDLINE
DCOM- 20200212
LR  - 20200212
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 55
IP  - 9
DP  - 2019 Sep 16
TI  - Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 
      2 Diabetes Mellitus.
LID - 10.3390/medicina55090596 [doi]
LID - 596
AB  - Diabetes mellitus represents a metabolic disorder the incidence of which has been 
      on the increase in recent years. The well-known long-term complications of this 
      disease encompass a wide spectrum of renal, neurological and cardiovascular 
      conditions. The aim of the study was to investigate the serum concentration of 
      endothelial microparticles (EMPs) as well as selected noninvasive parameters of 
      the ascending aorta stiffness calculated with echocardiography. In this study, 58 
      patients were enrolled-38 subjects diagnosed with type 2 diabetes mellitus (T2DM) 
      and 20 healthy controls. The analyzed populations did not differ significantly 
      with respect to age, renal function, systolic and diastolic blood pressure. The 
      patients with diabetes and concomitant hypertension presented higher levels of 
      EMPs in comparison with diabetic normotensive subjects. Among patients with 
      diabetes and hypertension, aortic stiffness assessed with the elasticity index 
      (Ep) was higher and the aortic compliance index (D) lower than in the diabetic 
      normotensive group. No correlation between the amount of EMPs and lipid profile, 
      C-reactive protein (CRP) level and glycemia, was observed in the studied group. 
      There was, however, a statistically significant positive correlation between the 
      creatinine level and amount of EMPs, while the negative relationship was 
      documented for EMPs level and the estimated glomerular filtration rate (eGFR).
FAU - Dec-Gilowska, Malgorzata
AU  - Dec-Gilowska M
AUID- ORCID: 0000-0002-7280-8143
AD  - Chair and Department of Internal Diseases, Medical University of Lublin, 20-059 
      Lublin, Poland. malgosdec@gmail.com.
AD  - Chair and Department of Internal Diseases and Diabetology, Medical University of 
      Warsaw, 02-091 Warsaw, Poland. malgosdec@gmail.com.
FAU - Trojnar, Marcin
AU  - Trojnar M
AD  - Chair and Department of Internal Diseases, Medical University of Lublin, 20-059 
      Lublin, Poland. maartinek@poczta.onet.pl.
FAU - Makaruk, Boguslaw
AU  - Makaruk B
AD  - Chair and Department of Internal Diseases, Medical University of Lublin, 20-059 
      Lublin, Poland. boguslawmakaruk@umlub.pl.
FAU - Czop, Marcin
AU  - Czop M
AUID- ORCID: 0000-0002-8113-5841
AD  - Department of Clinical Genetics, Medical University of Lublin, 20-059 Lublin, 
      Poland. marcinczop@umlub.pl.
FAU - Przybylska-Kuc, Sylwia
AU  - Przybylska-Kuc S
AD  - Chair and Department of Internal Diseases, Medical University of Lublin, 20-059 
      Lublin, Poland. 1@wp.pl.
FAU - Mosiewicz-Madejska, Barbara
AU  - Mosiewicz-Madejska B
AD  - Chair and Department of Internal Diseases, Medical University of Lublin, Students 
      Medical Association, 20-059 Lublin, Poland. bmosiewicz@gmail.com.
FAU - Dzida, Grzegorz
AU  - Dzida G
AD  - Chair and Department of Internal Diseases, Medical University of Lublin, 20-059 
      Lublin, Poland. grzegorzdzida@umlub.pl.
FAU - Mosiewicz, Jerzy
AU  - Mosiewicz J
AD  - Chair and Department of Internal Diseases, Medical University of Lublin, 20-059 
      Lublin, Poland. jerzy.mosiewicz@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190916
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Lipids)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Cell-Derived Microparticles/*pathology
MH  - Diabetes Mellitus, Type 2/blood/*complications/pathology
MH  - Diabetic Angiopathies/blood/*pathology
MH  - Echocardiography
MH  - Endothelium, Vascular/*cytology/pathology
MH  - Female
MH  - Humans
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - *Vascular Stiffness
PMC - PMC6780956
OTO - NOTNLM
OT  - aortic stiffness
OT  - compliance index
OT  - elasticity index
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflicts of interest.
EDAT- 2019/09/19 06:00
MHDA- 2020/02/13 06:00
PMCR- 2019/09/16
CRDT- 2019/09/19 06:00
PHST- 2019/06/20 00:00 [received]
PHST- 2019/08/30 00:00 [revised]
PHST- 2019/09/09 00:00 [accepted]
PHST- 2019/09/19 06:00 [entrez]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/02/13 06:00 [medline]
PHST- 2019/09/16 00:00 [pmc-release]
AID - medicina55090596 [pii]
AID - medicina-55-00596 [pii]
AID - 10.3390/medicina55090596 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2019 Sep 16;55(9):596. doi: 10.3390/medicina55090596.