PMID- 31528227 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1837-9664 (Print) IS - 1837-9664 (Electronic) IS - 1837-9664 (Linking) VI - 10 IP - 19 DP - 2019 TI - Wnt3a protein overexpression predicts worse overall survival in laryngeal squamous cell carcinoma. PG - 4633-4638 LID - 10.7150/jca.35009 [doi] AB - As a classical ligand in the canonical Wnt/beta-catenin signaling pathway, the role of Wnt3a in laryngeal squamous cell carcinoma (LSCC) remains unclear. Therefore, the expression pattern of the Wnt3a protein in 222 primary LSCC, and 19 corresponding adjacent non-carcinoma specimens, was detected by immunohistochemistry and further correlated with clinicopathological parameters. The results showed that LSCC tissue expressed higher levels of the Wnt3a protein when compared to the corresponding adjacent non-cancerous tissues. High expression of Wnt3a was closely related to histological grade (P = 0.031), clinical stage (I+II / III+IV; P = 0.004), and lymph node metastasis (P = 0.03). Kaplan-Meier analysis evidenced that a worse overall survival (OS) was correlated to the group with high Wnt3a expression (P = 0.003). When stratified survival analyses were performed, patients with lymph node metastasis/advanced clinical stages and high Wnt3a expression had worse OS rates than patients with other features (P < 0.001). Finally, multivariate analysis showed that Wnt3a expression was an independent prognosis factor for LSCC patients. The current findings suggest that Wnt3a is tightly related to the LSCC progression and could serve as a valuable clinic biomarker for LSCC patients. FAU - Zhang, Diekuo AU - Zhang D AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Li, Guo AU - Li G AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Chen, Xiyu AU - Chen X AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Jing, Qiancheng AU - Jing Q AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Department of Otolaryngology, Head and Neck Surgery, Changsha Central Hospital, 161 Shaoshan Road, Changsha, Hunan 410004, People's Republic of China. FAU - Liu, Chao AU - Liu C AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Lu, Shanhong AU - Lu S AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Huang, Donghai AU - Huang D AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Wang, Yunyun AU - Wang Y AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Tan, Pingqing AU - Tan P AD - Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, 283 Tongzipo Road, Changsha, Hunan 410013, People's Republic of China. FAU - Chen, Jie AU - Chen J AD - Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Tumor Hospital of Xiangya Medical School, Central South University, 283 Tongzipo Road, Changsha, Hunan 410013, People's Republic of China. FAU - Zhang, Xin AU - Zhang X AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Qiu, Yuanzheng AU - Qiu Y AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. FAU - Liu, Yong AU - Liu Y AD - Department of Otolaryngology, Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. AD - Otolaryngology Major Disease Research, Key Laboratory of Hunan Province, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China. LA - eng PT - Journal Article DEP - 20190808 PL - Australia TA - J Cancer JT - Journal of Cancer JID - 101535920 PMC - PMC6746142 OTO - NOTNLM OT - Laryngeal squamous cell carcinoma OT - Metastasis OT - Wnt3a OT - prognosis COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2019/09/19 06:00 MHDA- 2019/09/19 06:01 PMCR- 2019/01/01 CRDT- 2019/09/19 06:00 PHST- 2019/03/18 00:00 [received] PHST- 2019/06/19 00:00 [accepted] PHST- 2019/09/19 06:00 [entrez] PHST- 2019/09/19 06:00 [pubmed] PHST- 2019/09/19 06:01 [medline] PHST- 2019/01/01 00:00 [pmc-release] AID - jcav10p4633 [pii] AID - 10.7150/jca.35009 [doi] PST - epublish SO - J Cancer. 2019 Aug 8;10(19):4633-4638. doi: 10.7150/jca.35009. eCollection 2019.