PMID- 31528497
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2229-5097 (Print)
IS  - 2152-7806 (Electronic)
IS  - 2152-7806 (Linking)
VI  - 10
DP  - 2019
TI  - A surgical case of cerebellar tuberculoma caused by a paradoxical reaction while 
      on therapy for tuberculosis spondylitis.
PG  - 162
LID - 10.25259/SNI_318_2019 [doi]
LID - 162
AB  - BACKGROUND: A paradoxical reaction (PR) is a phenomenon in which the primary 
      tuberculous lesion worsens or another de novo tuberculous lesion appears while on 
      anti-tuberculosis therapy. Here, we report a rare case of cerebellar tuberculoma 
      caused by a PR during therapy for lumbar tuberculous spondylitis (Pott's 
      disease). CASE DESCRIPTION: A 47-year-old male with human immunodeficiency virus 
      seronegative was diagnosed with lumber tuberculous spondylitis (Pott's disease) 
      and prescribed anti-tuberculous agents. His lower back pain and inflammatory 
      condition recovered after initiation of anti-tuberculous therapy. Two months 
      later, he complained of headache, nausea, and staggering. Magnetic resonance 
      images revealed a ring-enhanced lesion located at the cerebellar hemisphere 
      extending to the vermis, which caused perifocal edema and bilateral 
      ventriculomegaly. These findings were consistent with his symptoms of 
      hydrocephalus. He did not have preceding clinical findings of meningitis, and a 
      PR was suggested to cause de novo aggregation of cerebellar tuberculoma. A 
      lesionectomy was performed, and the surgical specimen was pathologically 
      diagnosed as a tuberculoma. He recovered well from neurological disorders after 
      the resection. CONCLUSION: De novo formation of intracranial tuberculoma alone 
      caused by a PR without preceding meningitis is very rare. Lesionectomy is needed 
      for intracranial tuberculoma, which manifests as a mass effect, as well as 
      antituberculous therapy.
FAU - Ninomiya, Atsuhiko
AU  - Ninomiya A
AD  - Department of Neurosurgery, Sendai Medical Centre.
AD  - Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 
      Sendai, Japan.
FAU - Saito, Atsushi
AU  - Saito A
AD  - Department of Neurosurgery, Sendai Medical Centre.
FAU - Ishida, Tomohisa
AU  - Ishida T
AD  - Department of Neurosurgery, Sendai Medical Centre.
FAU - Inoue, Tomoo
AU  - Inoue T
AD  - Department of Neurosurgery, Sendai Medical Centre.
FAU - Inoue, Takashi
AU  - Inoue T
AD  - Department of Neurosurgery, Sendai Medical Centre.
FAU - Ezura, Masayuki
AU  - Ezura M
AD  - Department of Neurosurgery, Sendai Medical Centre.
FAU - Suzuki, Shinsuke
AU  - Suzuki S
AD  - Department of Neurosurgery, Sendai Medical Centre.
FAU - Uenohara, Hiroshi
AU  - Uenohara H
AD  - Department of Neurosurgery, Sendai Medical Centre.
FAU - Tominaga, Teiji
AU  - Tominaga T
AD  - Department of Neurosurgery, Graduate School of Medicine, Tohoku University, 
      Sendai, Japan.
LA  - eng
PT  - Case Reports
DEP - 20190809
PL  - United States
TA  - Surg Neurol Int
JT  - Surgical neurology international
JID - 101535836
PMC - PMC6744749
OTO - NOTNLM
OT  - Anti-tuberculous therapy
OT  - Cerebellar tumor
OT  - Paradoxical reaction
OT  - Pott's disease
OT  - Spinal tuberculosis
OT  - Tuberculoma
COIS- There are no conflicts of interest.
EDAT- 2019/09/19 06:00
MHDA- 2019/09/19 06:01
PMCR- 2019/08/09
CRDT- 2019/09/19 06:00
PHST- 2019/05/19 00:00 [received]
PHST- 2019/07/04 00:00 [accepted]
PHST- 2019/09/19 06:00 [entrez]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2019/09/19 06:01 [medline]
PHST- 2019/08/09 00:00 [pmc-release]
AID - SNI-10-162 [pii]
AID - 10.25259/SNI_318_2019 [doi]
PST - epublish
SO  - Surg Neurol Int. 2019 Aug 9;10:162. doi: 10.25259/SNI_318_2019. eCollection 2019.