PMID- 31529227
OWN - NLM
STAT- MEDLINE
DCOM- 20200211
LR  - 20200211
IS  - 1432-1971 (Electronic)
IS  - 0172-0643 (Linking)
VI  - 40
IP  - 8
DP  - 2019 Dec
TI  - Does Restrictive Lung Function Affect the Exercise Capacity in Patients with 
      Repaired Tetralogy of Fallot?
PG  - 1688-1695
LID - 10.1007/s00246-019-02205-0 [doi]
AB  - Patients with repaired Tetralogy of Fallot (rTOF) have decreased exercise 
      capacity (XC) and restrictive lung function (RLF). Our objective was to determine 
      the association between RLF and impaired XC in patients with rTOF. This was a 
      single center retrospective review of patients with rTOF who underwent a 
      cardiopulmonary treadmill exercise testing and spirometry from 2005 to 2015. 
      Patients with a respiratory exchange ratio >/= 1.05 and peak heart rate > 90% of 
      predicted value were included. Forced vital capacity (FVC) and Forced expiratory 
      volume in 1st second of forceful expiration (FEV(1)) were used to classify the 
      lung function. Exercise parameters such as peak oxygen uptake (VO(2)), % of 
      predicted VO(2) (%VO(2)), Metabolic equivalents (METS), and exercise time (ET) 
      were compared between the two groups (i) compared patients with normal lung 
      function (normal FEV(1), FVC, and FEV(1)/FVC > 80%) (ii) RLF (FVC < 80%, normal 
      or increased FEV(1)/FVC > 80%). In our cohort (n = 151, 52% male, mean age +/- SD 
      of 22.3 +/- 9.1 years), patients with RLF (n = 73) compared to those with normal 
      lung function (n = 86) had a lower peak VO(2) (30.8 +/- 8.6 vs. 
      36.6 +/- 9.8 mL/kg/min; p < 0.001) and shorter exercise time (9:23 +/- 1:78 vs. 
      10:23 +/- 1:62 min, p < 0.001). On multivariate regression analysis, RLF was 
      independently associated with reduced XC (VO(2)%) (beta-coefficient - 0.182, 
      p < 0.02) after controlling for age and gender. RLF is common in patients with 
      rTOF and is associated with decreased XC. The contribution of RLF to reduced XC 
      in this population should be considered prior to therapeutic decisions.
FAU - Akam-Venkata, Jyothsna
AU  - Akam-Venkata J
AUID- ORCID: 0000-0001-8625-6020
AD  - Division of Cardiology, Department of Pediatrics, The Carman and Ann Adams, Wayne 
      State University School of Medicine, Children's Hospital of Michigan, 3901 
      Beaubien Boulevard, Detroit, MI, USA. jyothsnaav@gmail.com.
FAU - Sriram, Chenni
AU  - Sriram C
AD  - Division of Cardiology, Department of Pediatrics, The Carman and Ann Adams, Wayne 
      State University School of Medicine, Children's Hospital of Michigan, 3901 
      Beaubien Boulevard, Detroit, MI, USA.
FAU - French, Michelle
AU  - French M
AD  - Division of Cardiology, Department of Pediatrics, The Carman and Ann Adams, Wayne 
      State University School of Medicine, Children's Hospital of Michigan, 3901 
      Beaubien Boulevard, Detroit, MI, USA.
FAU - Smith, Roxann
AU  - Smith R
AD  - Division of Cardiology, Department of Pediatrics, The Carman and Ann Adams, Wayne 
      State University School of Medicine, Children's Hospital of Michigan, 3901 
      Beaubien Boulevard, Detroit, MI, USA.
FAU - Aggarwal, Sanjeev
AU  - Aggarwal S
AD  - Division of Cardiology, Department of Pediatrics, The Carman and Ann Adams, Wayne 
      State University School of Medicine, Children's Hospital of Michigan, 3901 
      Beaubien Boulevard, Detroit, MI, USA.
LA  - eng
PT  - Journal Article
DEP - 20190917
PL  - United States
TA  - Pediatr Cardiol
JT  - Pediatric cardiology
JID - 8003849
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Exercise Test/methods
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Forced Expiratory Volume
MH  - Heart Valve Prosthesis Implantation/*adverse effects
MH  - Humans
MH  - Lung/*physiopathology
MH  - Male
MH  - Respiratory Function Tests
MH  - Retrospective Studies
MH  - Spirometry
MH  - Tetralogy of Fallot/physiopathology/*surgery
MH  - Young Adult
OTO - NOTNLM
OT  - Exercise capacity
OT  - Exercise time
OT  - Impaired aerobic capacity
OT  - Lung function
OT  - Repaired Tetralogy of Fallot
OT  - Restrictive lung function
EDAT- 2019/09/19 06:00
MHDA- 2020/02/12 06:00
CRDT- 2019/09/19 06:00
PHST- 2019/04/16 00:00 [received]
PHST- 2019/09/04 00:00 [accepted]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/02/12 06:00 [medline]
PHST- 2019/09/19 06:00 [entrez]
AID - 10.1007/s00246-019-02205-0 [pii]
AID - 10.1007/s00246-019-02205-0 [doi]
PST - ppublish
SO  - Pediatr Cardiol. 2019 Dec;40(8):1688-1695. doi: 10.1007/s00246-019-02205-0. Epub 
      2019 Sep 17.