PMID- 31529607
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20200917
IS  - 1527-6473 (Electronic)
IS  - 1527-6465 (Linking)
VI  - 25
IP  - 11
DP  - 2019 Nov
TI  - Integration of an Addiction Team in a Liver Transplantation Center.
PG  - 1611-1619
LID - 10.1002/lt.25641 [doi]
AB  - Up to 50% of liver transplantation (LT) recipients with known or clandestine 
      alcohol-use disorder (AUD) before surgery return to alcohol use after LT. 
      However, only severe alcohol relapse, which varies in frequency from 11% to 26% 
      of patients, has an impact on longterm survival and significantly decreases 
      survival rates after 10 years. Therefore, it is crucial to identify patients with 
      the highest risk of severe relapse in order to arrange specific, standardized 
      monitoring by an addiction team before and after LT. The aims of this study were 
      to describe the effects of combined management of AUD on the rate of severe 
      alcohol relapse and to determine the risk factors before LT that predict severe 
      relapse. Patients transplanted between January 2008 and December 2014 who had met 
      with the LT team's addiction specialist were included in the study. Patients who 
      exhibited alcohol-related relapse risk factors received specific addiction 
      follow-up. A total of 235 patients were enrolled in the study. Most of them were 
      men (79%), and the mean age at the time of the LT was 55.7 years. Severe relapse 
      occurred in only 9% of the transplant recipients. Alcohol-related factors of 
      severe relapse were a pretransplant abstinence of 6 months and family, legal, or 
      professional consequences of alcohol consumption, whereas the nonalcohol-related 
      factors were being single and being eligible for a disability pension. In 
      conclusion, the integration of an addiction team in a LT center may be 
      beneficial. The addiction specialist can identify patients at risk of severe 
      relapse in the pretransplantation period and hence arrange for specific 
      follow-up.
CI  - Copyright (c) 2019 by the American Association for the Study of Liver Diseases.
FAU - Donnadieu-Rigole, Helene
AU  - Donnadieu-Rigole H
AD  - Addictions Department, Saint Eloi Hospital, University Hospital of Montpellier, 
      Montpellier, France.
AD  - INSERM U 1058, Pathogenesis and Control of Chronic Infections, Montpellier, 
      France.
FAU - Jaubert, Laura
AU  - Jaubert L
AD  - Addictions Department, Saint Eloi Hospital, University Hospital of Montpellier, 
      Montpellier, France.
FAU - Ursic-Bedoya, Jose
AU  - Ursic-Bedoya J
AD  - Hepatology and Liver Transplantation Department, Saint Eloi Hospital, University 
      Hospital of Montpellier, Montpellier, France.
FAU - Hanslik, Bertrand
AU  - Hanslik B
AD  - Addictions Department, Saint Eloi Hospital, University Hospital of Montpellier, 
      Montpellier, France.
FAU - Mura, Thibault
AU  - Mura T
AD  - Medical Information Department, La Colombiere Hospital, University Hospital of 
      Montpellier, Montpellier, France.
AD  - Medical University of Montpellier, Montpellier, France.
FAU - Gamon, Lucie
AU  - Gamon L
AD  - Medical Information Department, La Colombiere Hospital, University Hospital of 
      Montpellier, Montpellier, France.
FAU - Faure, Stephanie
AU  - Faure S
AD  - Hepatology and Liver Transplantation Department, Saint Eloi Hospital, University 
      Hospital of Montpellier, Montpellier, France.
FAU - Navarro, Francis
AU  - Navarro F
AD  - Medical University of Montpellier, Montpellier, France.
AD  - Liver Surgery Department, Saint Eloi Hospital, University Hospital of 
      Montpellier, Montpellier, France.
FAU - Perney, Pascal
AU  - Perney P
AD  - Medical University of Montpellier, Montpellier, France.
AD  - Addictions Department, Caremeau Hospital, Nimes, France.
FAU - Herrero, Astrid
AU  - Herrero A
AD  - Medical University of Montpellier, Montpellier, France.
AD  - Liver Surgery Department, Saint Eloi Hospital, University Hospital of 
      Montpellier, Montpellier, France.
FAU - Pageaux, Georges-Philippe
AU  - Pageaux GP
AD  - Hepatology and Liver Transplantation Department, Saint Eloi Hospital, University 
      Hospital of Montpellier, Montpellier, France.
AD  - Medical University of Montpellier, Montpellier, France.
LA  - eng
PT  - Journal Article
DEP - 20191011
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
SB  - IM
MH  - Addiction Medicine
MH  - Aftercare/methods/organization & administration
MH  - Alcohol Abstinence/*statistics & numerical data
MH  - Alcoholism/diagnosis/epidemiology/*prevention & control/rehabilitation
MH  - Cohort Studies
MH  - Disease Progression
MH  - End Stage Liver Disease/pathology/surgery
MH  - Female
MH  - Humans
MH  - Liver Diseases, Alcoholic/pathology/surgery
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Patient Care Team/*organization & administration
MH  - Risk Factors
MH  - Secondary Prevention/methods/*organization & administration
MH  - Severity of Illness Index
EDAT- 2019/09/19 06:00
MHDA- 2020/09/18 06:00
CRDT- 2019/09/19 06:00
PHST- 2019/03/08 00:00 [received]
PHST- 2019/08/18 00:00 [accepted]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
PHST- 2019/09/19 06:00 [entrez]
AID - 10.1002/lt.25641 [doi]
PST - ppublish
SO  - Liver Transpl. 2019 Nov;25(11):1611-1619. doi: 10.1002/lt.25641. Epub 2019 Oct 
      11.