PMID- 31530029
OWN - NLM
STAT- MEDLINE
DCOM- 20200706
LR  - 20221207
IS  - 1607-842X (Electronic)
IS  - 0891-6934 (Linking)
VI  - 52
IP  - 5-6
DP  - 2019 Aug-Sep
TI  - IP-10 and MCP-1 gene polymorphisms in Chinese patients with chronic immune 
      thrombocytopenia.
PG  - 235-241
LID - 10.1080/08916934.2019.1666370 [doi]
AB  - Aberrant Th1/Th2 polarization is considered to play a crucial role in the 
      abnormal immune state of primary immune thrombocytopenia (ITP). IFN-gamma-inducible 
      protein of 10 kilodaltons (IP-10) and Monocyte chemoattractant protein-1 (MCP-1) 
      gene are involved in enhancing the Th1 and Th2 immune response, respectively. In 
      this study we investigated the distributions of IP-10 (-201 G/A) and MCP-1 
      (-2518 A/G) polymorphisms in 323 patients with chronic ITP and 255 healthy 
      controls by polymerase chain reaction (PCR)-restriction fragment length 
      polymorphism (RFLP). The IP-10 and MCP-1 levels of blood serum from 79 adult ITP 
      patients and 43 healthy controls were detected with ELISA. The frequency of 
      AG + AA genotype in IP-10 (-201 G/A) was significantly higher in ITP patients 
      than in controls, especially in female and adult patients. ITP patients showed 
      higher IP-10 levels than normal controls. Moreover, both IP-10 (-201 G/A) 
      heterozygote (GA) and homozygote minor allele (AA) patients had significantly 
      increased IP-10 levels compared to homozygote genotype (GG) patients at 
      diagnosis. No significant differences were revealed in genotypes and allele 
      distributions of MCP-1 (-2518 A/G) between ITP patients and normal controls, as 
      well as the MCP-1 levels. In conclusion, the -201 G/A polymorphism of IP-10 gene 
      may be associated with the susceptibility of ITP in Chinese population.
FAU - Zhang, Xian
AU  - Zhang X
AD  - The Hematology Department, Zhongnan Hospital of Wuhan University, Wuhan, China.
FAU - Zhang, Donglei
AU  - Zhang D
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Tianjin, China.
AD  - Tianjin Sino-US Diagnostics Co., Ltd, Tianjin, China.
FAU - Li, Huiyuan
AU  - Li H
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Tianjin, China.
FAU - Yang, Renchi
AU  - Yang R
AD  - State Key Laboratory of Experimental Hematology, Institute of Hematology and 
      Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union 
      Medical College, Tianjin, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190918
PL  - England
TA  - Autoimmunity
JT  - Autoimmunity
JID - 8900070
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL10 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CXCL10)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Chemokine CCL2/*genetics/immunology
MH  - Chemokine CXCL10/*genetics/immunology
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Chronic Disease
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Restriction Fragment Length
MH  - Purpura, Thrombocytopenic, Idiopathic/*genetics/immunology/pathology
OTO - NOTNLM
OT  - IP-10
OT  - Immune thrombocytopenia
OT  - MCP-1
OT  - pathogenesis
OT  - polymorphism
EDAT- 2019/09/19 06:00
MHDA- 2020/07/07 06:00
CRDT- 2019/09/19 06:00
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/07/07 06:00 [medline]
PHST- 2019/09/19 06:00 [entrez]
AID - 10.1080/08916934.2019.1666370 [doi]
PST - ppublish
SO  - Autoimmunity. 2019 Aug-Sep;52(5-6):235-241. doi: 10.1080/08916934.2019.1666370. 
      Epub 2019 Sep 18.