PMID- 31530176
OWN - NLM
STAT- MEDLINE
DCOM- 20200310
LR  - 20200310
IS  - 1938-2723 (Electronic)
IS  - 1076-0296 (Print)
IS  - 1076-0296 (Linking)
VI  - 25
DP  - 2019 Jan-Dec
TI  - Evaluation of Antifactor-Xa Heparin Assay and Activated Partial Thromboplastin 
      Time Values in Patients on Therapeutic Continuous Infusion Unfractionated Heparin 
      Therapy.
PG  - 1076029619876030
LID - 10.1177/1076029619876030 [doi]
LID - 1076029619876030
AB  - Clinical uncertainty exists regarding which assay should be designated as the 
      standard monitoring coagulation test for intravenous unfractionated heparin 
      (UFH). Several studies have compared the use of activated partial thromboplastin 
      time (aPTT) and antifactor-Xa (anti-Xa) and have come out with varying results. 
      The correlation between these 2 tests varied, markedly from strong to weak. Some 
      have demonstrated that monitoring with anti-Xa heparin assay leads to fewer dose 
      adjustments, resulting in fewer laboratory tests, while others have not. In the 
      current study, we evaluated the correlation between aPTT and anti-Xa values to 
      guide clinical management of UFH, with the intention to develop a new correlation 
      nomogram.
FAU - McLaughlin, Kevin
AU  - McLaughlin K
AUID- ORCID: 0000-0002-3259-3547
AD  - Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Rimsans, Jessica
AU  - Rimsans J
AD  - Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Sylvester, Katelyn W
AU  - Sylvester KW
AD  - Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Fanikos, John
AU  - Fanikos J
AD  - Department of Pharmacy, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Dorfman, David M
AU  - Dorfman DM
AD  - Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Senna, Patricia
AU  - Senna P
AD  - Department of Clinical Laboratories, Brigham and Women's Hospital, Boston, MA, 
      USA.
FAU - Connors, Jean M
AU  - Connors JM
AD  - Hematology Division, Brigham and Women's Hospital, Boston, MA, USA.
FAU - Goldhaber, Samuel Z
AU  - Goldhaber SZ
AD  - Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard 
      Medical School, Boston, MA, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 0 (Factor Xa Inhibitors)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Blood Coagulation Tests/*methods/standards
MH  - Factor Xa Inhibitors/analysis
MH  - Female
MH  - Heparin/administration & dosage/*therapeutic use
MH  - Humans
MH  - Infusion Pumps
MH  - Male
MH  - Middle Aged
MH  - Partial Thromboplastin Time
PMC - PMC6829967
OTO - NOTNLM
OT  - anticoagulants
OT  - bleeding
OT  - heparins
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2019/09/19 06:00
MHDA- 2020/03/11 06:00
PMCR- 2019/09/18
CRDT- 2019/09/19 06:00
PHST- 2019/09/19 06:00 [entrez]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/03/11 06:00 [medline]
PHST- 2019/09/18 00:00 [pmc-release]
AID - 10.1177_1076029619876030 [pii]
AID - 10.1177/1076029619876030 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619876030. doi: 
      10.1177/1076029619876030.