PMID- 31530619
OWN - NLM
STAT- MEDLINE
DCOM- 20201028
LR  - 20201028
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 9
IP  - 9
DP  - 2019 Sep 17
TI  - Passive versus active intra-abdominal drainage following pancreatic resection: 
      does a superior drainage system exist? A protocol for systematic review.
PG  - e031319
LID - 10.1136/bmjopen-2019-031319 [doi]
LID - e031319
AB  - BACKGROUND: Clinically relevant postoperative pancreatic fistula (CR-POPF) is the 
      most common cause of major morbidity following pancreatic resection. 
      Intra-abdominal drains are frequently positioned adjacent to the pancreatic 
      anastomosis or transection margin at the time of surgery to aid in detection and 
      management of CR-POPF. Drains can either evacuate fluid by passive gravity (PG) 
      or be attached to a closed suction (CS) system using negative pressure. There is 
      controversy as to whether one of these two systems is superior. The objective of 
      this review is to identify and compare the incidence of adverse events (AEs) and 
      resource utilisation associated with PG and CS drainage following pancreatic 
      resections. METHODS AND ANALYSIS: MEDLINE, EMBASE, CINAHL and Cochrane Central 
      Registry of Controlled Trials will be searched from inception to April 2019, to 
      identify interventional and observational studies comparing PG and CS drains 
      following pancreatic resection. The primary outcome is POPF as defined by the 
      International Study Group for Pancreatic Fistula in 2017. Secondary outcomes 
      include postoperative AE, resource utilisation (length of stay, return to 
      emergency department, readmission and reintervention), time to drain removal and 
      quality of life. Study selection, data extraction and risk of bias assessment 
      will be performed independently, by two reviewers. A meta-analysis will be 
      conducted if deemed statistically appropriate. Subgroup analysis by study design 
      will be performed. Study heterogeneity will be calculated with the chi(2) test and 
      reported as I(2) statistics. Statistical analyses will be conducted and displayed 
      using RevMan V.5.3 ETHICS AND DISSEMINATION: Ethics approval is not required. The 
      results of this study will be submitted to relevant conferences for presentation 
      and peer-reviewed journals for publication. PROSPERO REGISTRATION NUMBER: 
      CRD42019123647.
CI  - (c) Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Park, Lily
AU  - Park L
AUID- ORCID: 0000-0002-0372-3525
AD  - School of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Baker, Laura
AU  - Baker L
AUID- ORCID: 0000-0003-4711-3742
AD  - General Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.
FAU - Smith, Heather
AU  - Smith H
AD  - General Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada.
FAU - Davies, Alexandra
AU  - Davies A
AD  - Library Services, The Ottawa Hospital, Ottawa, Ontario, Canada.
FAU - Abou Khalil, Jad
AU  - Abou Khalil J
AD  - Hepatopancreaticobiliary Surgery, Department of Surgery, The Ottawa Hospital, 
      Ottawa, Ontario, Canada.
AD  - Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, 
      Canada.
FAU - Martel, Guillaume
AU  - Martel G
AD  - Hepatopancreaticobiliary Surgery, Department of Surgery, The Ottawa Hospital, 
      Ottawa, Ontario, Canada.
AD  - Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, 
      Canada.
FAU - Balaa, Fady
AU  - Balaa F
AD  - Hepatopancreaticobiliary Surgery, Department of Surgery, The Ottawa Hospital, 
      Ottawa, Ontario, Canada.
FAU - Bertens, Kimberly A
AU  - Bertens KA
AD  - Hepatopancreaticobiliary Surgery, Department of Surgery, The Ottawa Hospital, 
      Ottawa, Ontario, Canada kbertens@toh.ca.
AD  - Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, 
      Canada.
LA  - eng
PT  - Journal Article
DEP - 20190917
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Abdomen
MH  - Device Removal/adverse effects/mortality
MH  - Drainage/*methods
MH  - Humans
MH  - Length of Stay
MH  - Pancreas/*surgery
MH  - Pancreatic Fistula/*epidemiology
MH  - Postoperative Complications/*epidemiology
MH  - Quality of Life
MH  - Research Design
MH  - Systematic Reviews as Topic
PMC - PMC6756355
OTO - NOTNLM
OT  - drains
OT  - fistula
OT  - pancreatic surgery
COIS- Competing interests: None declared.
EDAT- 2019/09/19 06:00
MHDA- 2020/10/29 06:00
PMCR- 2019/09/17
CRDT- 2019/09/19 06:00
PHST- 2019/09/19 06:00 [entrez]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/10/29 06:00 [medline]
PHST- 2019/09/17 00:00 [pmc-release]
AID - bmjopen-2019-031319 [pii]
AID - 10.1136/bmjopen-2019-031319 [doi]
PST - epublish
SO  - BMJ Open. 2019 Sep 17;9(9):e031319. doi: 10.1136/bmjopen-2019-031319.