PMID- 31531812
OWN - NLM
STAT- MEDLINE
DCOM- 20201005
LR  - 20211204
IS  - 1867-1462 (Electronic)
IS  - 1867-1462 (Linking)
VI  - 12
IP  - 1
DP  - 2020 Mar
TI  - A Systems Biology Roadmap to Decode mTOR Control System in Cancer.
PG  - 1-11
LID - 10.1007/s12539-019-00347-6 [doi]
AB  - Mechanistic target of rapamycin (mTOR) is a critical protein in the regulation of 
      cell fate decision making, especially in cancer cells. mTOR acts as a signal 
      integrator and is one of the main elements of interactions among the pivotal 
      cellular processes such as cell death, autophagy, metabolic reprogramming, cell 
      growth, and cell cycle. The temporal control of these processes is essential for 
      the cellular homeostasis and dysregulation of mTOR signaling pathway results in 
      different phenotypes, including aging, oncogenesis, cell survival, cell growth, 
      senescence, quiescence, and cell death. In this paper, we have proposed a systems 
      biology roadmap to study mTOR control system, which introduces the theoretical 
      and experimental modalities to decode temporal and dynamical characteristics of 
      mTOR signaling in cancer.
FAU - Dorvash, Mohammadreza
AU  - Dorvash M
AD  - Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, 
      Shiraz, Iran.
AD  - Cell and Molecular Medicine Student Research Group, Faculty of Medicine, Shiraz 
      University of Medical Sciences, Shiraz, Iran.
FAU - Farahmandnia, Mohammad
AU  - Farahmandnia M
AD  - Cell and Molecular Medicine Student Research Group, Faculty of Medicine, Shiraz 
      University of Medical Sciences, Shiraz, Iran.
FAU - Tavassoly, Iman
AU  - Tavassoly I
AUID- ORCID: 0000-0002-2258-1091
AD  - Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, 
      1425 Madison Ave, New York, NY, 10029, USA. iman.tavassoly@mssm.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190917
PL  - Germany
TA  - Interdiscip Sci
JT  - Interdisciplinary sciences, computational life sciences
JID - 101515919
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cellular Senescence/genetics/physiology
MH  - Humans
MH  - Models, Theoretical
MH  - Systems Biology/*methods
MH  - TOR Serine-Threonine Kinases/genetics/*metabolism
OTO - NOTNLM
OT  - Aging
OT  - Bistability
OT  - Cancer
OT  - Cell fate
OT  - Dynamic modeling
OT  - Mathematical models
OT  - Oscillations
OT  - Signaling network
OT  - Systems biology
OT  - mTOR
EDAT- 2019/09/19 06:00
MHDA- 2020/10/06 06:00
CRDT- 2019/09/19 06:00
PHST- 2019/07/05 00:00 [received]
PHST- 2019/09/04 00:00 [accepted]
PHST- 2019/08/26 00:00 [revised]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/10/06 06:00 [medline]
PHST- 2019/09/19 06:00 [entrez]
AID - 10.1007/s12539-019-00347-6 [pii]
AID - 10.1007/s12539-019-00347-6 [doi]
PST - ppublish
SO  - Interdiscip Sci. 2020 Mar;12(1):1-11. doi: 10.1007/s12539-019-00347-6. Epub 2019 
      Sep 17.