PMID- 31532135
OWN - NLM
STAT- MEDLINE
DCOM- 20191001
LR  - 20191001
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 44
IP  - 9
DP  - 2019 Sept 25
TI  - [Electroacupuncture at "Zusanli"(ST36) and "Xuanzhong"(GB39) improves 
      inflammatory reactions and reduces levels of serum MMP-3 and MMP-9 in adjuvant 
      arthritis rats].
PG  - 659-62
LID - 10.13702/j.1000-0607.180555 [doi]
AB  - OBJECTIVE: To observe the effect of electroacupuncture (EA) at "Zusanli" (ST36) 
      and "Xuanzhong" (GB39) on joint inflammatory reactions and serum matrix 
      metalloproteinase-3 (MMP-3) and MMP-9 contents in rats with adjuvant arthritis 
      (AA), so as to explore its mechanism underlying improvement of AA. METHODS: Forty 
      male SD rats were randomly divided into control, model, acupoint and non-acupoint 
      groups (n=10 in each group). The arthritis model was established by hypodermic 
      injection of complete Freund's adjuvant (0.1 mL) into the bilateral footpads. EA 
      (2 Hz, 3 V) was applied to bilateral ST36 and GB39 or two non-acupoints (5 mm 
      left to ST36 and GB39) for 15 min, once every other day for a total of 8 times. 
      The arthritis index score was evaluated according to the severity of local 
      erythema and swelling of the ankle joint, plantar joint, toe joint and foot 
      metacarpal joint (0-4 points). The inflammatory conditions of the ankle joint 
      were observed by H.E. staining, and the contents of serum MMP-3 and MMP-9 were 
      assayed by ELISA. RESULTS: The arthritis index score and serum concentrations of 
      MMP-3 and MMP-9 were significantly increased in the model group relevant to the 
      control group (P<0.01), and obviously decreased after EA intervention on the 
      18(th) day (P<0.01). The therapeutic effect of acupoint EA was notably superior 
      to non-acupoint EA in down-regulating the arthritis index score and serum MMP-3 
      and MMP-9 concentrations (P<0.01). Under light microscope, marked proliferation 
      of the synovial cells, inflammatory cell infiltration and increase of newly blood 
      vessels were observed in the ankle joint of the model group, which was relatively 
      milder in the acupoint group. CONCLUSION: acupoint EA intervention can 
      significantly alleviate the inflammatory reaction of AA rats, which may be 
      related to its effects in reducing the levels of serum MMP-3 and MMP-9.
FAU - Chen, Yu-Zhou
AU  - Chen YZ
AD  - Department of Acupuncture-moxibustion and Tuina, The Third Affiliated Hospital, 
      Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
FAU - Su, Cheng-Guo
AU  - Su CG
AD  - Department of Acupuncture-moxibustion and Tuina, The Third Affiliated Hospital, 
      Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
FAU - Chen, Tai-Lin
AU  - Chen TL
AD  - Department of Acupuncture-moxibustion and Tuina, The Third Affiliated Hospital, 
      Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
FAU - Chen, Yun-Fei
AU  - Chen YF
AD  - Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200437.
FAU - Li, Lian-Bo
AU  - Li LB
AD  - Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai 
      University of Traditional Chinese Medicine, Shanghai 200437.
FAU - Zhu, Jun
AU  - Zhu J
AD  - Department of Acupuncture-moxibustion and Tuina, The Third Affiliated Hospital, 
      Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
SB  - IM
MH  - Acupuncture Points
MH  - Animals
MH  - *Arthritis, Experimental
MH  - *Electroacupuncture
MH  - Inflammation
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Adjuvant arthritis
OT  - Arthritis index score
OT  - Electroacupuncture
OT  - Matrix metalloproteinase
EDAT- 2019/09/19 06:00
MHDA- 2019/10/02 06:00
CRDT- 2019/09/19 06:00
PHST- 2019/09/19 06:00 [entrez]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2019/10/02 06:00 [medline]
AID - 10.13702/j.1000-0607.180555 [doi]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2019 Sept 25;44(9):659-62. doi: 10.13702/j.1000-0607.180555.