PMID- 31532921
OWN - NLM
STAT- MEDLINE
DCOM- 20200601
LR  - 20200601
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 9
IP  - 12
DP  - 2019 Dec
TI  - Diamine oxidase enzyme: a novel biomarker in respiratory allergy.
PG  - 1478-1484
LID - 10.1002/alr.22426 [doi]
AB  - BACKGROUND: Well-known allergy tests are used to evaluate and diagnose allergic 
      diseases. The aim of this study was to assess the role of serum level diamine 
      oxidase (DAO) enzyme as a diagnostic marker in respiratory allergy. METHODS: This 
      case-control study included 40 patients with respiratory allergies (atopic asthma 
      and allergic rhinitis) as well as 40 age- and sex-matched controls. A detailed 
      past medical history of allergy was collected from each participant including 
      family history of allergy. Physical examination, pulmonary function test (PFT) 
      and measurement of serum levels of total immunoglobulin E (IgE) and DAO were 
      performed. Skin-prick test and specific IgE to common aeroallergens were also 
      carried out. RESULTS: DAO levels were higher in patients than controls. There was 
      a positive correlation between severity of disease and DAO. No significant 
      association was found between DAO level and age, type of respiratory allergy, 
      duration of disease, PFT, eosinophilia, and total IgE. DAO had a high negative 
      predictive value (94.7%) and high sensitivity (97.5%). CONCLUSION: DAO may be 
      helpful in the assessment of severity and in ruling out respiratory allergy.
CI  - (c) 2019 ARS-AAOA, LLC.
FAU - Refaat, Maged M
AU  - Refaat MM
AD  - Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams 
      University, Faculty of Medicine, Cairo, Egypt.
FAU - Abdel-Rehim, Asmaa S
AU  - Abdel-Rehim AS
AD  - Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams 
      University, Faculty of Medicine, Cairo, Egypt.
FAU - Elmahdi, Amira R
AU  - Elmahdi AR
AD  - Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams 
      University, Faculty of Medicine, Cairo, Egypt.
FAU - Mohamed, Nesrine A
AU  - Mohamed NA
AD  - Department of Clinical Pathology and Immunology, Ain Shams University, Faculty of 
      Medicine, Cairo, Egypt.
FAU - Ghonaim, Sara S
AU  - Ghonaim SS
AD  - Department of Internal Medicine, Allergy and Clinical Immunology, Ain Shams 
      University, Faculty of Medicine, Cairo, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20190918
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 0 (Biomarkers)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 1.4.3.21 (Amine Oxidase (Copper-Containing))
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/immunology
MH  - Amine Oxidase (Copper-Containing)/*blood
MH  - Asthma/*blood/immunology/physiopathology
MH  - Biomarkers/blood
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Rhinitis, Allergic/*blood/immunology/physiopathology
MH  - Severity of Illness Index
MH  - Skin Tests
MH  - Young Adult
OTO - NOTNLM
OT  - DAO
OT  - allergic rhinitis
OT  - allergy tests
OT  - bronchial asthma
OT  - diamine oxidase
OT  - skin-prick test
OT  - specific IgE
OT  - total IgE
EDAT- 2019/09/19 06:00
MHDA- 2020/06/02 06:00
CRDT- 2019/09/19 06:00
PHST- 2019/04/15 00:00 [received]
PHST- 2019/08/09 00:00 [revised]
PHST- 2019/08/13 00:00 [accepted]
PHST- 2019/09/19 06:00 [pubmed]
PHST- 2020/06/02 06:00 [medline]
PHST- 2019/09/19 06:00 [entrez]
AID - 10.1002/alr.22426 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2019 Dec;9(12):1478-1484. doi: 10.1002/alr.22426. Epub 
      2019 Sep 18.