PMID- 31533216
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 9
IP  - 3
DP  - 2019 Sep 17
TI  - Left Ventricular Diastolic Dysfunction in Type 2 Diabetes-Progress and 
      Perspectives.
LID - 10.3390/diagnostics9030121 [doi]
LID - 121
AB  - In-depth understanding of early cardiovascular manifestations in diabetes is high 
      on international research and prevention agendas given that cardiovascular events 
      are the leading cause of death for diabetic patients. Our aim was to review 
      recent developments in the echocardiographic assessment of left ventricular 
      diastolic dysfunction (LVDD) as a telltale pre-clinical disturbance preceding 
      diabetic cardiomyopathy. We analyzed papers in which patients had been 
      comprehensively assessed echocardiographically according to the latest LVDD 
      guidelines (2016), and those affording comparisons with previous, widely used 
      recommendations (2009). We found that the updated algorithm for LVDD is more 
      effective in predicting adverse cardiovascular events in patients with 
      established LVDD, and less specific in grading other patients (labelled 
      "indeterminate"). This may prove instrumental for recruiting "indeterminate" LVDD 
      cases among patients with type 2 diabetes mellitus (T2DM) in future screening 
      programs. As an interesting consideration, the elevated values of the index E/e' 
      can point to early diastolic impairment, foretelling diabetic cardiomyopathy. 
      Identifying subclinical signs early makes clinical sense, but the complex nature 
      of T2DM calls for further research. Specifically, longitudinal studies on 
      rigorously selected cohorts of diabetic patients are needed to better understand 
      and predict the subtle, slow onset of cardiac manifestations with T2DM as a 
      complicating backdrop.
FAU - Grigorescu, Elena-Daniela
AU  - Grigorescu ED
AUID- ORCID: 0000-0002-7721-554X
AD  - Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University of 
      Medicine and Pharmacy, 700115 Iasi, Romania.
FAU - Lacatusu, Cristina-Mihaela
AU  - Lacatusu CM
AUID- ORCID: 0000-0002-9012-5901
AD  - Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University of 
      Medicine and Pharmacy, 700115 Iasi, Romania. cristina.lacatusu@umfiasi.ro.
AD  - "Sf. Spiridon" Emergency Hospital, 700111 Iasi, Romania. 
      cristina.lacatusu@umfiasi.ro.
FAU - Floria, Mariana
AU  - Floria M
AUID- ORCID: 0000-0002-9465-1503
AD  - "Sf. Spiridon" Emergency Hospital, 700111 Iasi, Romania. 
      floria_mariana@yahoo.com.
AD  - Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 
      Iasi, Romania. floria_mariana@yahoo.com.
FAU - Mihai, Bogdan-Mircea
AU  - Mihai BM
AD  - Diabetes, Nutrition and Metabolic Diseases, "Grigore T. Popa" University of 
      Medicine and Pharmacy, 700115 Iasi, Romania. bogdan.mihai@umfiasi.ro.
AD  - "Sf. Spiridon" Emergency Hospital, 700111 Iasi, Romania. bogdan.mihai@umfiasi.ro.
FAU - Cretu, Ioana
AU  - Cretu I
AD  - Department Preventive Medicine and Interdisciplinarity, "Grigore T. Popa" 
      University of Medicine and Pharmacy, 700115 Iasi, Romania. 
      ioana.cretu@umfiasi.ro.
FAU - Sorodoc, Laurentiu
AU  - Sorodoc L
AD  - "Sf. Spiridon" Emergency Hospital, 700111 Iasi, Romania. 
      laurentiu.sorodoc@gmail.com.
AD  - Internal Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 
      Iasi, Romania. laurentiu.sorodoc@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190917
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC6787758
OTO - NOTNLM
OT  - E/e' index
OT  - diabetic cardiomyopathy
OT  - echocardiography
OT  - left ventricular diastolic dysfunction
OT  - type 2 diabetes
COIS- The authors declare no conflict of interest.
EDAT- 2019/09/20 06:00
MHDA- 2019/09/20 06:01
PMCR- 2019/09/17
CRDT- 2019/09/20 06:00
PHST- 2019/08/31 00:00 [received]
PHST- 2019/09/11 00:00 [revised]
PHST- 2019/09/15 00:00 [accepted]
PHST- 2019/09/20 06:00 [entrez]
PHST- 2019/09/20 06:00 [pubmed]
PHST- 2019/09/20 06:01 [medline]
PHST- 2019/09/17 00:00 [pmc-release]
AID - diagnostics9030121 [pii]
AID - diagnostics-09-00121 [pii]
AID - 10.3390/diagnostics9030121 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2019 Sep 17;9(3):121. doi: 10.3390/diagnostics9030121.