PMID- 31533814
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200225
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 12
IP  - 1
DP  - 2019 Sep 18
TI  - Resistance training-induced gains in knee extensor strength are related to 
      increased neural cell adhesion molecule expression in older adults with knee 
      osteoarthritis.
PG  - 595
LID - 10.1186/s13104-019-4642-0 [doi]
LID - 595
AB  - OBJECTIVE: Resistance training (RT) can improve whole muscle strength without 
      increasing muscle fiber size or contractility. Neural adaptations, which lead to 
      greater neural activation of muscle, may mediate some of these improvements, 
      particularly in older adults, where motor neuron denervation is common. The 
      purpose of this study was to explore the relationship of neural adaptations, as 
      reflected by neural cell adhesion molecule (NCAM) expression, to improvements in 
      (1) whole muscle strength and (2) muscle fiber size following RT in older adults 
      with knee osteoarthritis. We performed whole muscle strength measurements and 
      immunohistochemical analysis of fiber size, type, and NCAM expression before and 
      after a 14-week RT program. RESULTS: RT increased whole-muscle strength as 
      measured by 1-repetition maximum (1-RM) leg press (P = 0.01), leg extension 
      (P = 0.03), and knee extensor peak torque (P = 0.050), but did not alter NCAM 
      expression. Greater NCAM expression in myosin heavy chain (MHC) II fibers was 
      associated with greater whole muscle strength gains (knee extensor peak torque 
      r = 0.93; P < 0.01) and greater MHC II fiber size (r = 0.79; P < 0.01). Our 
      results suggest that training-induced NCAM expression, and neural adaptations 
      more generally, may be important for RT-induced morphological and functional 
      improvements in older adults. Trial registration NCT01190046.
FAU - Voigt, Thomas B
AU  - Voigt TB
AD  - Department of Medicine, College of Medicine, University of Vermont, Burlington, 
      VT, USA.
FAU - Tourville, Timothy W
AU  - Tourville TW
AD  - Department of Orthopedics and Rehabilitation, College of Medicine, University of 
      Vermont, Burlington, VT, USA.
AD  - Department of Rehabilitation and Movement Science, College of Nursing and Health 
      Sciences, University of Vermont, Burlington, VT, USA.
FAU - Falcone, Michael J
AU  - Falcone MJ
AD  - Department of Medicine, College of Medicine, University of Vermont, Burlington, 
      VT, USA.
AD  - Department of Orthopedics and Rehabilitation, College of Medicine, University of 
      Vermont, Burlington, VT, USA.
FAU - Slauterbeck, James R
AU  - Slauterbeck JR
AD  - Department of Orthopedics and Rehabilitation, College of Medicine, University of 
      Vermont, Burlington, VT, USA.
FAU - Beynnon, Bruce D
AU  - Beynnon BD
AD  - Department of Orthopedics and Rehabilitation, College of Medicine, University of 
      Vermont, Burlington, VT, USA.
FAU - Toth, Michael J
AU  - Toth MJ
AD  - Department of Medicine, College of Medicine, University of Vermont, Burlington, 
      VT, USA. Michael.Toth@med.uvm.edu.
AD  - Department of Molecular Physiology and Biophysics, College of Medicine, 
      University of Vermont, Health Science Research Facility 126B, 149 Beaumont Ave, 
      Burlington, VT, 05405, USA. Michael.Toth@med.uvm.edu.
AD  - Department of Orthopedics and Rehabilitation, College of Medicine, University of 
      Vermont, Burlington, VT, USA. Michael.Toth@med.uvm.edu.
LA  - eng
SI  - ClinicalTrials.gov/NCT01190046
GR  - R01 AG033547/AG/NIA NIH HHS/United States
GR  - AG-033547/NH/NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
DEP - 20190918
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Neural Cell Adhesion Molecules)
SB  - IM
MH  - Adaptation, Physiological
MH  - Aged
MH  - Female
MH  - Humans
MH  - Knee/*physiopathology
MH  - Knee Joint/metabolism/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Muscle Fibers, Skeletal/metabolism/physiology
MH  - Muscle Strength/physiology
MH  - Muscle, Skeletal/metabolism/*physiopathology
MH  - Neural Cell Adhesion Molecules/*metabolism
MH  - Osteoarthritis, Knee/metabolism/*physiopathology
MH  - Resistance Training/*methods
MH  - Torque
PMC - PMC6751848
OTO - NOTNLM
OT  - Aging
OT  - Denervation
OT  - Exercise
OT  - Hypertrophy
OT  - Osteoarthritis
OT  - Reinnervation
COIS- The authors declare that they have no competing interests.
EDAT- 2019/09/20 06:00
MHDA- 2020/02/11 06:00
PMCR- 2019/09/18
CRDT- 2019/09/20 06:00
PHST- 2019/04/09 00:00 [received]
PHST- 2019/09/11 00:00 [accepted]
PHST- 2019/09/20 06:00 [entrez]
PHST- 2019/09/20 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/09/18 00:00 [pmc-release]
AID - 10.1186/s13104-019-4642-0 [pii]
AID - 4642 [pii]
AID - 10.1186/s13104-019-4642-0 [doi]
PST - epublish
SO  - BMC Res Notes. 2019 Sep 18;12(1):595. doi: 10.1186/s13104-019-4642-0.