PMID- 31534637
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220410
IS  - 2213-8862 (Electronic)
IS  - 1991-7902 (Print)
IS  - 1991-7902 (Linking)
VI  - 14
IP  - 3
DP  - 2019 Sep
TI  - Diagnostic accuracy of salivary biomarkers of bone turnover in identifying 
      patients with periodontitis in a Saudi Arabian population.
PG  - 269-276
LID - 10.1016/j.jds.2019.03.002 [doi]
AB  - BACKGROUND/PURPOSE: Salivary markers of bone turnover are useful biomarkers for 
      screening patients advanced periodontal diseases with alveolar bone loss. Hence, 
      the purpose of this study was to determine the diagnostic accuracy of 
      deoxypyridinoline-containing degradation fragment of the C-terminal telopeptide 
      region of type I collagen (CTX), Osteocalcin (OC) and Osteonectin (ON) in 
      identifying patients with alveolar bone loss (BL) due to periodontitis. MATERIALS 
      AND METHOD: Salivary levels of CTX, OC and ON were evaluated in ninety patients 
      (group I, II and III with healthy, periodontitis without Type2 diabetes 
      mellitus-T2DM and periodontitis with T2DM respectively). Group III was included 
      since T2DM is very common among patients attending our clinics. Bleeding on 
      probing (BOP), probing pocket depth (PPD) and BL were recorded for these 
      patients. RESULTS: The concentrations of salivary CTX, OC, and ON were higher in 
      subjects with periodontitis than in controls. Significant correlations were found 
      between these biomarkers and periodontal parameters. CTX, OC, and ON could 
      discriminate between healthy (group I) and diseased (group II & III) regarding BL 
      with excellent sensitivity (90.2-100%) and good specificity (62.1-96.6%). ROC 
      curve gave excellent discrimination regarding BL (AUC: 0.926-0.958) and PPD (AUC: 
      0.904-0.915). However, none of the cut-off values gave good discrimination 
      regarding BOP. CONCLUSION: It can be concluded that CTX, OC, and ON correlated 
      well with BL and PPD. Among the three biomarkers, ON at 81.80 ng/ml gave the best 
      discrimination for presence or absence of bone loss.
FAU - Betsy, Joseph
AU  - Betsy J
AD  - Department of Periodontics and Community Dental Sciences, Division of 
      Periodontics, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
FAU - Ahmed, Javali Mukhatar
AU  - Ahmed JM
AD  - Department of Periodontics and Community Dental Sciences, Division of 
      Periodontics, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
FAU - Mohasin, Abdul Khader
AU  - Mohasin AK
AD  - Department of Periodontics and Community Dental Sciences, Division of 
      Periodontics, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
FAU - Mohammed, Amanullah
AU  - Mohammed A
AD  - Department of Clinical Biochemistry, College of Medicine, King Khalid University, 
      Gureiger, Abha, Saudi Arabia.
FAU - Nabeeh A, AlQahtani
AU  - Nabeeh A A
AD  - Department of Periodontics and Community Dental Sciences, Division of 
      Periodontics, College of Dentistry, King Khalid University, Abha, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20190329
PL  - Netherlands
TA  - J Dent Sci
JT  - Journal of dental sciences
JID - 101293181
PMC - PMC6742844
OTO - NOTNLM
OT  - Alveolar bone loss (BL)
OT  - C-terminal telopeptide region of type I collagen (CTX)
OT  - Osteocalcin (OC)
OT  - Osteonectin (ON)
OT  - Probing pocket depth (PPD)
OT  - Salivary
EDAT- 2019/09/20 06:00
MHDA- 2019/09/20 06:01
PMCR- 2019/03/29
CRDT- 2019/09/20 06:00
PHST- 2018/11/29 00:00 [received]
PHST- 2019/03/06 00:00 [revised]
PHST- 2019/09/20 06:00 [entrez]
PHST- 2019/09/20 06:00 [pubmed]
PHST- 2019/09/20 06:01 [medline]
PHST- 2019/03/29 00:00 [pmc-release]
AID - S1991-7902(18)31107-3 [pii]
AID - 10.1016/j.jds.2019.03.002 [doi]
PST - ppublish
SO  - J Dent Sci. 2019 Sep;14(3):269-276. doi: 10.1016/j.jds.2019.03.002. Epub 2019 Mar 
      29.