PMID- 31535402
OWN - NLM
STAT- MEDLINE
DCOM- 20210429
LR  - 20210429
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 121
IP  - 2
DP  - 2020 Feb
TI  - Mesenchymal stem cells combined with traditional Chinese medicine 
      (qi-fang-bi-min-tang) alleviates rodent allergic rhinitis.
PG  - 1541-1551
LID - 10.1002/jcb.29389 [doi]
AB  - Mesenchymal stem cells (MSCs) have been proved to exert anti-inflammatory effects 
      and regulate immune reactions. Traditional Chinese medicine (TCM), 
      qi-fang-bi-min-tang, is effective for some patients with allergic diseases. 
      However, it remains unclear whether MSCs combined with TCM could benefit the 
      treatment of allergic rhinitis (AR). In this study, we reported an additional 
      effect of TCM (qi-fang-bi-min-tang) on the therapy of AR under MSCs treatment. 
      Intriguingly, we observed that TCM-treated MSCs significantly inhibited the 
      symptoms of AR and reduced the pathological changes of nasal mucosa in ovalbumin 
      (OVA)-induced rats. The expression levels of interferon gamma (IFN-gamma), interleukin-17 
      (IL-17), and IL-4 were significantly decreased in the plasma of AR rats after 
      injection of TCM-treated MSCs. TCM-treated MSCs reduced the levels of histamine 
      secreted by mast cells and immunoglobulin E (IgE) secreted by plasma cells. In 
      addition, we found that MSCs combined with TCM had a better therapeutic effect 
      than TCM alone on AR in an OVA-induced mouse model. After OVA induction, MSCs 
      combined with TCM significantly reduced the ratio of T helper type 1 (Th1), Th2, 
      and Th17, but increased the proportion of Treg in the spleen of mice. 
      Consistently, the expression levels of IFN-gamma, IL-4, and IL-17 were significantly 
      decreased, but transforming growth factor-beta1 was significantly increased in the 
      plasma of AR mice after treated with TCM and MSCs. Our results from both rats and 
      mice indicated that the effects of TCM combined with MSCs on the AR might be 
      through regulating the secretion of Th1, Th2, and Th17 cytokines. This study 
      suggested that TCM (qi-fang-bi-min-tang)-treated MSCs could be used in the 
      clinical therapy of AR.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Fu, Yanxia
AU  - Fu Y
AD  - School of Medicine, State Key Laboratory of Membrane Biology, Tsinghua 
      University, Beijing, China.
AD  - Tsinghua University-Perking University Joint Center for Life Sciences, Beijing, 
      China.
FAU - Kong, Yanhua
AU  - Kong Y
AD  - Beijing Key Laboratory, The Key Institute of state Administration of Traditional 
      Chinese Medicine, Beijing, China.
FAU - Li, Jun
AU  - Li J
AD  - Institute of Immunology, PLA, The Third Military Medical University, Chongqing, 
      China.
FAU - Wang, Yi
AU  - Wang Y
AD  - School of Medicine, State Key Laboratory of Membrane Biology, Tsinghua 
      University, Beijing, China.
FAU - Li, Mengdi
AU  - Li M
AD  - School of Medicine, State Key Laboratory of Membrane Biology, Tsinghua 
      University, Beijing, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - School of Medicine, State Key Laboratory of Membrane Biology, Tsinghua 
      University, Beijing, China.
FAU - Wang, Yinyin
AU  - Wang Y
AD  - School of Medicine, State Key Laboratory of Membrane Biology, Tsinghua 
      University, Beijing, China.
FAU - Ren, Fangli
AU  - Ren F
AD  - School of Medicine, State Key Laboratory of Membrane Biology, Tsinghua 
      University, Beijing, China.
FAU - Ni, Jian
AU  - Ni J
AD  - Institute of Traditional Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Li, Youlin
AU  - Li Y
AD  - Beijing Key Laboratory, The Key Institute of state Administration of Traditional 
      Chinese Medicine, Beijing, China.
FAU - Chang, Zhijie
AU  - Chang Z
AUID- ORCID: 0000-0002-1590-2619
AD  - School of Medicine, State Key Laboratory of Membrane Biology, Tsinghua 
      University, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190918
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Cytokines)
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Allografts
MH  - Animals
MH  - Cytokines/immunology
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Mesenchymal Stem Cells/*immunology/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Rhinitis, Allergic/immunology/pathology/*therapy
MH  - T-Lymphocytes, Helper-Inducer/immunology/pathology
OTO - NOTNLM
OT  - T help cells
OT  - allergic rhinitis
OT  - inflammatory cytokines
OT  - mesenchymal stem cells
OT  - qi-fang-bi-min-tang
OT  - traditional Chinese medicine
EDAT- 2019/09/20 06:00
MHDA- 2021/04/30 06:00
CRDT- 2019/09/20 06:00
PHST- 2018/09/15 00:00 [received]
PHST- 2019/03/15 00:00 [accepted]
PHST- 2019/09/20 06:00 [pubmed]
PHST- 2021/04/30 06:00 [medline]
PHST- 2019/09/20 06:00 [entrez]
AID - 10.1002/jcb.29389 [doi]
PST - ppublish
SO  - J Cell Biochem. 2020 Feb;121(2):1541-1551. doi: 10.1002/jcb.29389. Epub 2019 Sep 
      18.