PMID- 31535457
OWN - NLM
STAT- MEDLINE
DCOM- 20200619
LR  - 20200619
IS  - 1754-9485 (Electronic)
IS  - 1754-9477 (Linking)
VI  - 63
IP  - 6
DP  - 2019 Dec
TI  - The medial breast margin sign: A new sign of pectus excavatum in adult females 
      and comparison with classic signs.
PG  - 737-744
LID - 10.1111/1754-9485.12949 [doi]
AB  - INTRODUCTION: Pectus excavatum (PX) denotes a concavity of the sternum and is the 
      most common chest wall deformity. Many characteristic signs have been described 
      on frontal chest radiographs including increased density of the inferomedial 
      right lung, blurring of the right heart border, steeply angled anterior ribs, 
      horizontal posterior ribs, straight or convex left heart border and loss of 
      silhouette of the descending thoracic aorta. These signs are often subtle and 
      rarely all present in any individual. We describe a further sign in women with 
      PX, the medial breast margin sign. This sign consists of more sharply defined and 
      more vertically oriented medial breast borders on frontal chest radiographs than 
      in those of women with normal chest wall morphology. This study aims to document 
      the sensitivity, specificity and inter-observer reliability of the new sign, and 
      compare with that of the previously described signs in patients with varying 
      degrees of PX. METHODS: The frontal chest radiographs of 185 women with PX and 50 
      women with normal chest wall morphology were assessed by two reviewers for the 
      presence of the new sign and previously described signs. All the signs had their 
      sensitivity, specificity and inter-observer reliability calculated. RESULTS: The 
      new sign had a sensitivity of 0.48, a specificity of 0.96 and inter-observer 
      reliability of kappa = 0.79, ranking third, second and first among all other signs, 
      respectively. CONCLUSION: The medial breast margin sign is useful in diagnosing 
      PX and is comparable to the previously described classic signs.
CI  - (c) 2019 The Royal Australian and New Zealand College of Radiologists.
FAU - Hapuarachchi, Kamal S
AU  - Hapuarachchi KS
AUID- ORCID: 0000-0001-7843-0412
AD  - Department of Radiology, Christchurch Hospital, Christchurch, New Zealand.
FAU - Cowan, Ian A
AU  - Cowan IA
AD  - Everlight Radiology, Sydney, New South Wales, Australia.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190918
PL  - Australia
TA  - J Med Imaging Radiat Oncol
JT  - Journal of medical imaging and radiation oncology
JID - 101469340
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Breast/*diagnostic imaging
MH  - Female
MH  - Funnel Chest/*diagnostic imaging
MH  - Humans
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tomography, X-Ray Computed/*methods
MH  - Young Adult
OTO - NOTNLM
OT  - funnel chest
OT  - medial breast margin sign
OT  - pectus excavatum
OT  - pectus excavatum on frontal chest radiographs
OT  - radiological signs of pectus excavatum
EDAT- 2019/09/20 06:00
MHDA- 2020/06/20 06:00
CRDT- 2019/09/20 06:00
PHST- 2019/05/19 00:00 [received]
PHST- 2019/08/06 00:00 [revised]
PHST- 2019/08/12 00:00 [accepted]
PHST- 2019/09/20 06:00 [pubmed]
PHST- 2020/06/20 06:00 [medline]
PHST- 2019/09/20 06:00 [entrez]
AID - 10.1111/1754-9485.12949 [doi]
PST - ppublish
SO  - J Med Imaging Radiat Oncol. 2019 Dec;63(6):737-744. doi: 10.1111/1754-9485.12949. 
      Epub 2019 Sep 18.