PMID- 31539535
OWN - NLM
STAT- MEDLINE
DCOM- 20200708
LR  - 20210816
IS  - 1878-5867 (Electronic)
IS  - 0039-128X (Linking)
VI  - 152
DP  - 2019 Dec
TI  - Estrogen signaling and estrogen receptors as prognostic indicators in laryngeal 
      cancer.
PG  - 108498
LID - S0039-128X(19)30188-6 [pii]
LID - 10.1016/j.steroids.2019.108498 [doi]
AB  - Laryngeal squamous cell carcinoma (LSCC) has been shown to respond to 
      17beta-estradiol. However, the presence and characterization of estrogen receptors 
      (ER) and other sex hormone receptors in LSCC are still being determined. Sex 
      hormone receptors and the way sex hormones impact LSCC tumors are important for 
      understanding which patients would benefit from hormone therapies, such as 
      anti-estrogen therapies. This information also has prognostic value, as there may 
      be a correlation between ER profiles and LSCC aggression. Recent work by our team 
      and others has shown that the canonical ER, estrogen receptor alpha (ERalpha), and its 
      splice variant ERalpha36, are important modulators of estrogen signaling in LSCC. 
      This review describes some common 17beta-estradiol signaling pathways, and explains 
      how these signaling pathways might control LSCC tumor growth. We also show that 
      loss of ERalpha, but not ERalpha36, imbues LSCC with enhanced aggression, a pattern which 
      has previously only been observed in breast cancer. We make a case for using ERalpha 
      as a tumorigenic modulator and pathogenic marker in LSCC on par with the use of 
      ERalpha as a prognostic marker in breast cancer.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Verma, Anjali
AU  - Verma A
AD  - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 
      VA, USA.
FAU - Schwartz, Nofrat
AU  - Schwartz N
AD  - Department of Otolaryngology, Meir Hospital, Kfar Saba, Israel; Sackler Faculty 
      of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Otolaryngology 
      - Head and Neck Surgery and Neurosurgery, University of North Carolina School of 
      Medicine, Chapel Hill, NC, USA.
FAU - Cohen, D Joshua
AU  - Cohen DJ
AD  - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 
      VA, USA.
FAU - Boyan, Barbara D
AU  - Boyan BD
AD  - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 
      VA, USA; Department of Biomedical Engineering, Georgia Institute of Technology, 
      Atlanta, GA, USA.
FAU - Schwartz, Zvi
AU  - Schwartz Z
AD  - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, 
      VA, USA; Department of Periodontics, University of Texas Health Science Center at 
      San Antonio, San Antonio, TX, USA. Electronic address: zschwartz@vcu.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190917
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogens)
SB  - IM
MH  - Biomarkers, Tumor/analysis/*metabolism
MH  - Breast Neoplasms/diagnosis/*metabolism
MH  - Estrogen Receptor alpha/analysis/*metabolism
MH  - Estrogens/analysis/*metabolism
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*metabolism
MH  - *Signal Transduction
OTO - NOTNLM
OT  - ERalpha36
OT  - Estrogen receptor alpha
OT  - Laryngeal cancer
EDAT- 2019/09/21 06:00
MHDA- 2020/07/09 06:00
CRDT- 2019/09/21 06:00
PHST- 2019/03/18 00:00 [received]
PHST- 2019/09/03 00:00 [revised]
PHST- 2019/09/09 00:00 [accepted]
PHST- 2019/09/21 06:00 [pubmed]
PHST- 2020/07/09 06:00 [medline]
PHST- 2019/09/21 06:00 [entrez]
AID - S0039-128X(19)30188-6 [pii]
AID - 10.1016/j.steroids.2019.108498 [doi]
PST - ppublish
SO  - Steroids. 2019 Dec;152:108498. doi: 10.1016/j.steroids.2019.108498. Epub 2019 Sep 
      17.