PMID- 31539796
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20200127
IS  - 1532-2661 (Electronic)
IS  - 0034-5288 (Linking)
VI  - 126
DP  - 2019 Oct
TI  - The chemical and ultra-structural analysis of thin plastic films used for 
      surgical attenuation of portosystemic shunts in dogs and cats.
PG  - 192-198
LID - S0034-5288(18)35282-2 [pii]
LID - 10.1016/j.rvsc.2019.08.023 [doi]
AB  - The objective of the study was to (1) characterize and compare the chemical 
      composition at the surface, subsurface and in the bulk of thin plastic films used 
      for portosystemic shunt attenuation in their native state and after plasma 
      exposure. (2) Assess the presence, concentration and location of irritant 
      compounds (e.g dicetyl phosphate) within the films. Attenuated Total Reflectance 
      Infrared Spectroscopy (ATR-IR), X-ray Photoelectron Spectroscopy (XPS) and 
      dynamic Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) were used to 
      analyze thirteen thin plastic films. Sample thickness was visualized and measured 
      using Scanning Electron Microscopy (SEM). Sample thicknesses were compared using 
      a one-way ANOVA. XPS reported low phosphorous concentrations (surrogate marker of 
      dicetyl phosphate) between 0.01 and 0.19% wt at the sample surfaces (top 10 nm). 
      There were significant differences between film thicknesses (P < .001) observed 
      by SEM. The ATR-IR and ToF-SIMS identified four distinct surface and bulk 
      chemical profiles: 1) Cellophane, 2) Polypropylene, 3) Modified Cellophane, and 
      4) Unique. Following plasma immersion for 6 weeks, samples showed little change 
      in film thickness or chemical composition. This study confirmed that films used 
      to attenuate portosystemic shunts were commonly not pure cellophane, with 
      significant variations in surface and bulk chemistry. Suspected irritant 
      compounds were not readily identifiable in significant proportions. Pronounced 
      variability existed in both the thickness and chemical composition of these films 
      (surface vs. bulk). The present findings lead to a legitimate question about the 
      reproducibility of shunt occlusion when using thin plastic films from different 
      origins.
CI  - Copyright (c) 2019. Published by Elsevier Ltd.
FAU - Field, ElinorJ
AU  - Field E
AD  - University of Bristol, Faculty of Health and Science, Bristol Veterinary School, 
      UK.
FAU - Scurr, David J
AU  - Scurr DJ
AD  - University of Nottingham, School of Pharmacy, Advanced Materials and Healthcare 
      Technologies, UK.
FAU - Piggott, Matthew J
AU  - Piggott MJ
AD  - University of Nottingham, School of Pharmacy, Advanced Materials and Healthcare 
      Technologies, UK.
FAU - Anderson, Thomas S
AU  - Anderson TS
AD  - University of Bristol, Faculty of Health and Science, Bristol Veterinary School, 
      UK.
FAU - Chanoit, Guillaume P
AU  - Chanoit GP
AD  - University of Bristol, Faculty of Health and Science, Bristol Veterinary School, 
      UK. Electronic address: g.chanoit@bristol.ac.uk.
LA  - eng
PT  - Journal Article
DEP - 20190823
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Plastics)
SB  - IM
MH  - Animals
MH  - Cats
MH  - Dogs
MH  - Microscopy, Electron, Scanning/veterinary
MH  - Photoelectron Spectroscopy/veterinary
MH  - Plastics/*analysis/*chemistry
MH  - Portasystemic Shunt, Surgical/statistics & numerical data/*veterinary
MH  - Reproducibility of Results
MH  - Spectrometry, Mass, Secondary Ion/veterinary
MH  - Spectrophotometry, Infrared/veterinary
MH  - Surface Properties
OTO - NOTNLM
OT  - Cellophane band
OT  - Chemistry
OT  - Portosystemic shunt
OT  - Spectroscopy
OT  - Thin plastic film
EDAT- 2019/09/21 06:00
MHDA- 2020/01/28 06:00
CRDT- 2019/09/21 06:00
PHST- 2018/11/09 00:00 [received]
PHST- 2019/08/05 00:00 [revised]
PHST- 2019/08/12 00:00 [accepted]
PHST- 2019/09/21 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
PHST- 2019/09/21 06:00 [entrez]
AID - S0034-5288(18)35282-2 [pii]
AID - 10.1016/j.rvsc.2019.08.023 [doi]
PST - ppublish
SO  - Res Vet Sci. 2019 Oct;126:192-198. doi: 10.1016/j.rvsc.2019.08.023. Epub 2019 Aug 
      23.